项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Tilnoprofen arbamel, Y-23023

替洛芬阿酯替洛芬酯 Chemical Name: (?-2-(2-Methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid N,N-dimethylcarbamoylmethyl ester; (?-alpha,2-Dimethyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid N,N-...
参考文献标题:Benzopyranopyridine acid ester cpds.and their pharmaceutical uses
文献作者:Oe,T.; Kawasaki,K.; Terasawa,M.; Imayoshi,T.(Japan Tobacco Inc.; Welfide Corporation)
参考来源:EP 0284069; JP 1989025782; US 4808593

Moxantrazole, Teloxantrone, DuP-937, CI-937, PD-113309, NSC-355644

替洛蒽醌 6-羟基-2-{2-[(2-羟基)氨基]乙基}-5-{[2-(甲基氨基)乙基]氨基}-1,2-二氢二苯并[CD,G]勻唑-7,10-二盐酸二酮 Chemical Name: 7,10-Dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino)ethyl]amino]anthra[1,9-cd]pyrazol-6(2H)...
参考文献标题:CI-937 and CI-942
文献作者:Hoshi,A.
参考来源:Drugs Fut 1986,11(3),179

Tiropramide, CR-605, Tirospan, Maioral, Alfospas(HCl), Maiorad(HCl)

替瑞酰胺盐酸替瑞酰胺 Chemical Name: D,L-alpha-Benzamido-p-[2-(diethylamino)ethoxy]-N,N-dipropylhydrocinnamamide; (?-alpha-(Benzoylamino)-4-[2-(diethylamino)ethoxy]-N,N-dipropylbenzenepropanamide
CAS No. 558...
参考文献标题:O-Tertiary amino-alkyl-N-benzoyl tyrosil amides
文献作者:Makovec,F.; Rovati,L.; Senini,P.(Rotta Research Laboratorium SpA)
参考来源:DE 2503992; FR 2259592; GB 1467927; JP 50116442; NL 167683C; US 4004008

Tesmilifene hydrochloride, BMY-33419, BMS-217380, DPPE, N,N-DPPE

替米利芬替米利芬 Chemical Name: 2-(4-Benzylphenoxy)-N,N-diethylethylamine hydrochloride
CAS No. 92981-78-7, 98774-23-3 (free base)
项目整合开发状态: Phase III
项目研究机构: YM BioSciences (Proprietary), Universi...
参考文献标题:Novel cytotoxic aminoalkyl phenol ethers
文献作者:Hermonat,M.W.; Brandes,L.J.(University of Manitoba)
参考来源:EP 0153160; JP 1985190742; US 4803227

Timiperone, DD-3480, Tolopelon

替米哌隆Chemical Name: 1-(4-Fluorophenyl)-4-[4-(2-thioxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]butan-1-one
CAS No. 57648-21-2
项目整合开发状态: Launched
项目研究机构: Daiichi Pharmaceutical (Originat...
参考文献标题:DD-3480
文献作者:Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1978,3(6),451

Telmisartan, YM-086, BIBR-277-SE, BIBR-277, Kinzalmono, Pritor, Micardis

替米沙坦Chemical Name: 4'-[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid
CAS No. 144701-48-4
项目整合开发状态: Launched-1999
项目研究机构: Boehringer...
参考文献标题:Benzimidazoles,medicaments containing them and process for their preparation
文献作者:Hauel,N.; Narr,B.; Ries,U.; Van Meel,J.; Wienen,W.; Entzeroth,M.(Dr.Karl Thomae GmbH)
参考来源:DE 4103492; DE 4117121; EP 0502314; EP 0543263; JP 1992346978

Teroxirone, NSC-296934, alpha-TGT, alpha-TGI

替罗昔隆 b-三甘油苷异氰脲酸盐 Chemical Name: [1(R*),3(R*),5(S*)]-(?-1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; (RS,RS,SR)-1,3,5-Tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione; alph...
参考文献标题:Therapeutic compsns.with a cytostatic action
文献作者:Schnegelberger,H.; Budnowski,M.(Henkel KgA)
参考来源:GB 2044614

Timegadine, SR-1368

替美加定Chemical Name: N-Cyclohexyl-N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine; 1-Cyclohexyl-2-(2-methyl-4-quinolyl)-3-(2-thiazolyl)guanidine
CAS No. 71079-19-1
项目整合开发状态: Phase III
项目研究机构: ...
参考文献标题:Timegadine
文献作者:Blancafort,P.; Castar,J.; Arrigoni-Martelli,E.; Serradell,M.N.
参考来源:Drugs Fut 1981,6(6),369

Temelastine, SK&F-93944

替美斯汀Chemical Name: 2-[4-(3-Bromo-5-methylpyridin-6-yl)butylamino]-5-(6-methylpyridin-3-ylmethyl)pyrimidin-4(1H)-one
CAS No. 86181-42-2
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Or...
参考文献标题:Histamine H1-antagonists
文献作者:Sach,G.S.(SmithKline Beecham plc)
参考来源:DD 202291; EP 0068833; EP 0068834; JP 58008079; JP 61233616; JP 61233670; US 4444772; US 4486434; US 4535163; US 4584381

Teichomycin, Teicoplanin, MDL-507, Targocid, Targosid

替考拉宁替考拉宁 A2 Chemical Name: Glycopeptide antibiotic produced by fermentation of Actinoplanes teichomyceticus nov. sp.
CAS No. 61036-62-2 (Teichomycin A1), 61036-64-4 (Teichomycin A2)
项目整合开发状态: L...
参考文献标题:Total synthesis of the vancomycin aglycon
文献作者:Boger,D.L.; et al.
参考来源:J Am Chem Soc 1999,121(43),10004