合成路线:The reaction of adenosine-3',5'-cyclic phosphate (I) with butyric anhydride (II) in the presence of triethylamine gives N6,2'-O-dibutyryladenosine-3',5'-cyclic phosphate (III),which is then treated with Na-type Amberlite IR-120 B.
合成路线:The reaction of 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (I) with 4-aminopyridine (II) gives the corresponding pyridinium salt (III),which is reduced with NaBH4 to 2-[3-(4-aminopiperidyl)propyl]-2-(4-fluorophenyl)-1,3-dioxolane (IV).The condensation of (IV) with 2-chloronitrobenzene (V) yields 2-[3-[4-(2-nitroanilino)piperidyl]propyl]-2-(4-fluorophenyl)-1,3-dioxolane (VI),which is hydrogenated with H2 over Raney-Ni affording the corresponding amino compound (VII).Finally this compound is cyclized with carbon disulfide and KOH
合成路线:The reaction of o-phenylenediamine (IX) with 4-chloropyridine (VIII) gives 2-(4-pyridylamino)aniline (X),which is condensed with 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (I) to give the corresponding pyridinium salt (XI).The reduction of (XI) with NaBH4 yields amino compound (VII).Finally this compound is cyclized with carbon disulfide and KOH
参考文献标题:
文献作者:
参考来源:JP 76095096
合成路线:By condesation of 4-chloro-1-(4-fluorophenyl)-1-butanone ethylene ketal (I) with 1-(4-piperidyl)-2-mercaptobenzimidazole (II) by means of KI in refluxing butanol
合成路线:The condensation of 4-chloro-1-(4-fluorophenyl)-1-butanone ethylene ketal (I) with 4-(2-nitroanilino)piperidine (III) by means of KI in refluxing butanol gives 1-[3-(4-fluorobenzoyl)propyl]-4-(2-nitroanilino)piperidine ethylene ketal (IV),which is reduced with H2 over Raney-Ni in methanol yielding the corresponding amino compound (V).Finally this compound is cyclized with CS2 by means of KOH in refluxing ethanol
参考文献标题:
文献作者:Katsujiro,U.; et al.(Daiichi Seiyaku Co.,Ltd.)
参考来源:DE 2526393; GB 1467097; US 3963727
合成路线:The condensation of 4-chloro-1-(4-fluorophenyl)-1-butanone ethylene ketal (I) with 4-(2-nitroanilino)piperidine (III) by means of KI in refluxing butanol gives 1-[3-(4-fluorobenzoyl)propyl]-4-(2-nitroanilino)piperidine ethylene ketal (IV),which is reduced with H2 over Raney-Ni in methanol yielding the corresponding amino compound (V).Finally this compound is cyclized with CS2 by means of KOH in refluxing ethanol
参考文献标题:
文献作者:Katsujiro,U.; et al.(Daiichi Seiyaku Co.,Ltd.)
参考来源:BE 830171; ZA 7593577
合成路线:By condesation of 4-chloro-1-(4-fluorophenyl)-1-butanone ethylene ketal (I) with 1-(4-piperidyl)-2-mercaptobenzimidazole (II) by means of KI in refluxing butanol
参考文献标题:
文献作者:Sato,A.(Daiichi Seiyaku Co.,Ltd.)
参考来源:JP 7584578
合成路线:The condensation of 4-chloro-1-(4-fluorophenyl)-1-butanone ethylene ketal (I) with 4-(2-nitroanilino)piperidine (III) by means of KI in refluxing butanol gives 1-[3-(4-fluorobenzoyl)propyl]-4-(2-nitroanilino)piperidine ethylene ketal (IV),which is reduced with H2 over Raney-Ni in methanol yielding the corresponding amino compound (V).Finally this compound is cyclized with CS2 by means of KOH in refluxing ethanol
参考文献标题:
文献作者:Katsujiro,U.; et al.(Daiichi Seiyaku Co.,Ltd.)
参考来源:JP 7584579
合成路线:By heating a mixture of 1-[1-[3-(4-fluorobenzoyl)propyl]-4-piperidyl]benzimidazol-2-one (VI) and P2S5
参考文献标题:
文献作者:Sato,M.; et al.(Daiichi Seiyaku Co.,Ltd.)
参考来源:JP 76128974
产品链接: CAS No. 57648-21-2››