Timegadine, SR-1368
替美加定Chemical Name: N-Cyclohexyl-N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine; 1-Cyclohexyl-2-(2-methyl-4-quinolyl)-3-(2-thiazolyl)guanidine
CAS No. 71079-19-1
项目整合开发状态: Phase III
项目研究机构: Leo (Originator)
合成路线:The dehydration of N-cyclohexyl-N'-(2-methyl-4-quinolyl)urea (I) with triphenylphosphine,CCl4 and triethylamine in refluxing methylene chloride gives N-cyclohexyl-N'-(2-methyl-4-quinolyl)carbodiimide (II),which is then condensed with 2-aminothiazole (III) in refluxing toluene.
📌 参考资料/链接：
参考文献标题:Timegadine
文献作者:Blancafort,P.; Castar,J.; Arrigoni-Martelli,E.; Serradell,M.N.
参考来源:Drugs Fut 1981,6(6),369
📄 详细内容
合成路线:The dehydration of N-cyclohexyl-N'-(2-methyl-4-quinolyl)urea (I) with triphenylphosphine,CCl4 and triethylamine in refluxing methylene chloride gives N-cyclohexyl-N'-(2-methyl-4-quinolyl)carbodiimide (II),which is then condensed with 2-aminothiazole (III) in refluxing toluene.
参考文献标题:Basic antiinflammatory compounds,N,N1,N2-trisubstituted guanidines
文献作者:Rachlin,S.; Bramm,E.; Ahnfelt-Ronne,I.; Arrigoni-Martelli,E.
参考来源:J Med Chem 1980,23(1),13-20
合成路线:The dehydration of N-cyclohexyl-N'-(2-methyl-4-quinolyl)urea (I) with triphenylphosphine,CCl4 and triethylamine in refluxing methylene chloride gives N-cyclohexyl-N'-(2-methyl-4-quinolyl)carbodiimide (II),which is then condensed with 2-aminothiazole (III) in refluxing toluene.
参考文献标题:
文献作者:
参考来源:DE 2847792
产品链接: CAS No. 71079-19-1››