Tilnoprofen arbamel, Y-23023
替洛芬阿酯 替洛芬酯 Chemical Name: (?-2-(2-Methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid N,N-dimethylcarbamoylmethyl ester; (?-alpha,2-Dimethyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid N,N-dimethylcarbamoylmethyl ester
CAS No. 159098-79-0, 118635-52-2 (undefined stereoch.)
项目整合开发状态: Phase III
项目研究机构: Japan Tobacco (Originator), Mitsubishi Pharma (Originator)
合成路线:By esterification of 2-(2-methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid (I) with 2-chloro-N,N-dimethylacetamide (II) by means of K2CO3 in hot DMF.
📌 参考资料/链接：
参考文献标题:Benzopyranopyridine acid ester cpds.and their pharmaceutical uses
文献作者:Oe,T.; Kawasaki,K.; Terasawa,M.; Imayoshi,T.(Japan Tobacco Inc.; Welfide Corporation)
参考来源:EP 0284069; JP 1989025782; US 4808593
📄 详细内容
合成路线:By esterification of 2-(2-methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid (I) with 2-chloro-N,N-dimethylacetamide (II) by means of K2CO3 in hot DMF.
参考文献标题:Synthesis,pharmacological activity and biopharmaceutical characteristics of alpha,2-dimethyl-5H-[1]benzopyrano[2,3-d]pyridine-7-acetates
文献作者:Kawasaki,K.; Yamada,I.; Oe,T.; Tsuruda,M.; Terasawa,M.; Imayoshi,T.; Yasunaga,Y.; Goto,K.
参考来源:Yakugaku Zasshi 1989,109(11),827
合成路线:By esterification of 2-(2-methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid (I) with 2-chloro-N,N-dimethylacetamide (II) by means of K2CO3 in hot DMF.
参考文献标题:Y-23023
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1992,17(6),469
产品链接: CAS No. 159098-79-0›› 产品链接: CAS No.118635-52-2››