项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Tipranavir, PNU-140690E(diNa salt), PNU-140690, U-140690

替拉那韦 2-吡啶磺酰胺,N-[3-[(1R)-1-[(6R)-5,6-二氢-4-羟基-2-氧基-6-(2-苯乙基)-6-丙基-2H-吡门-3-基]丙基]苯基]-5-(三氟甲基)-钠盐(1:2) Chemical Name: N-[3-[1(R)-[4-Hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]pro...
参考文献标题:Pyranone cpds.useful to treat retroviral infections
文献作者:Romines,K.R.; Bundy,G.L.; Schwartz,T.M.; Tommasi,R.A.; Strohbach,J.W.; Turner,S.R.; Thaisrivongs,S.; Aristoff,P.A.; Johnson,P.D.; Skulnick,H.I.; Skaletzki,L.L.; Anderson,D.J.; Morris,J.; Gammill,R.B.; Luke,G.P.(Pharmacia Corp.)
参考来源:EP 0758327; JP 1997512821; US 5852195; WO 9530670

Teglicar, ST-1326

替格列卡Chemical Name: 3(R)-[3-(Tetradecyl)ureido]-4-(trimethylammonium)butyrate
CAS No. 250694-07-6
项目整合开发状态: Clinical
项目研究机构: Sigma-Tau (Originator)
合成路线:Pentadecanoyl chloride (I) is treate...
参考文献标题:Cpds.having reversible inhibiting activity of carnitine palmitoyl-transferase
文献作者:Marzi,M.; Tinti,M.O.; Giannessi,F.; Minetti,P.; De Angelis,F.; Chiodi,P.; Arduini,A.(Sigma-Tau Industrie Farmaceutiche Riunite SpA)
参考来源:EP 1077925; US 6369073; WO 9959957

Tesaglitazar, AZ-242, AR-H039242XX, Galida

替格列扎Chemical Name: 2(S)-Ethoxy-3-[4-[2-[4-(methylsulfonyloxy)phenyl]ethoxy]phenyl]propionic acid
CAS No. 251565-85-2, 251565-88-5 (undefined isomer)
项目整合开发状态: Phase III
项目研究机构: AstraZeneca (O...
参考文献标题:New 3-aryl-2-aryl propionic acid derivs.and analogs
文献作者:Andersson,K.; Boije,M.; Inghardt,T.; Lindstedt Alstermark,E.-L.; Gottfries,J.; Li,L.(AstraZeneca plc)
参考来源:EP 1084101; EP 1084102; EP 1084103; WO 9962870; WO 9962871; WO 9962872

Tebipenem pivoxil, L-084

替比培南酯Chemical Name: (1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[1-(2-thiazolin-2-yl)azetidin-3-ylsulfanyl]-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester
CAS No. 161715-24-8
项目整合开发状态...
参考文献标题:2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivs.
文献作者:Abe,T.; Isoda,T.; Sato,C.; Mihira,A.; Tamai,S.; Kumagai,T.(Lederle (Japan),Ltd.)
参考来源:EP 0632039; EP 0717042; JP 1996053453; US 5534510; US 5659043; US 5783703

Telbivudine, LDT-600, LdT, L-dT, NV-02B

替比夫定Chemical Name: 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-beta-L-thymidine; 1-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyri...
参考文献标题:2' or 3'-Deoxy and 2'-dideoxy-beta-L-pentafuranonucleoside cpds.,method of preparation and application in therapy,especially as anti-viral agents
文献作者:Gosselin,G.; Imbach,J.-L.; Aubertin,A.-M.; Sommadossi,J.-P.; Schinazi,R.F.(CNRS (Centre National de la Recherche Scientifique))
参考来源:DE 2709754; EP 0717748; WO 9507287

Tiflucarbine, TVX-P-4495

替氟卡宾Chemical Name: 1-Methyl-9-ethyl-4-fluoro-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole
CAS No. 89875-86-5
项目整合开发状态: Biological Testing
项目研究机构: Troponwerke (Originator)
合成路线:The r...
参考文献标题:7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole,a process for their preparation and medicaments containing them
文献作者:Sch鰈lnhammer,G.; Seidel,P.-R.(Troponwerke GmbH & Co KG)
参考来源:EP 0120439; US 4816461

Tifluadom, KC-5103

替氟朵Chemical Name: N-[5-(2-Fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-2-ylmethyl]thiophene-3-carboxamide; 1-Methyl-2-(3-thienylcarboxamidomethyl)-5-(2-fluorophenyl)-1H-2,3-dihydro-1,4-benz...
参考文献标题:2-Acylaminomethyl-1,4-benzodiazepine derivs.and their salts and pharmaceutical compsns.thereof
文献作者:Zeugner,H.; R鰉er,D.; Liepmann,H.; Milkowski,W.(Kali-Chemie AG)
参考来源:US 4325957

Tefludazine, Lu-18012

替氟达嗪Chemical Name: trans-4-[3-(4-Fluorophenyl)-2,3-dihydro-6-(trifluoromethyl)-1H-inden-1-yl]-1-piperazineethanol; trans-4-[3-(p-Fluorophenyl)-6-(trifluoromethyl)-1-indanyl]-1-piperazineethanol; trans...
参考文献标题:Tefludazine
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(5),346

Tepoxalin, RWJ-20485, Orf-20485

替泊沙林Chemical Name: 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide; 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-N-methylpyrazole-3-propionohydroxamic acid; 5-(4-Chlorop...
参考文献标题:The regioselective synthesis of tepoxalin,3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide and related 1,5-diarylpyrazole antiinflammatory agents
文献作者:Forerokelly,Y.; Murray,W.; Wachter,M.; Barton,D.
参考来源:Synthesis 1991,1(1),18

Tipredane, SQ-27239

替泼尼旦Chemical Name: 17alpha-(Ethylsulfanyl)-9alpha-fluoro-11beta-hydroxy-17beta-(methylsulfanyl)androsta-1,4-dien-3-one
CAS No. 85197-77-9
项目整合开发状态: Phase III
项目研究机构: Bristol-Myers Squibb (Ori...
参考文献标题:Antiinflammatory 17,17-bis(substd.thio)androstene
文献作者:Varma,R.K.(Bristol-Myers Squibb Co.)
参考来源:US 4361559