项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Delprostenate, ONO-1052

地前列酯Chemical Name: 2(E)-16-(3-Chlorophenoxy)-2,3-didehydro-17,18,19,20-tetranorprostaglandin F2alpha methyl ester
CAS No. 62524-99-6
项目整合开发状态: Not Determined
项目研究机构:
合成路线:This compound ca...
参考文献标题:16-Phenoxy and phenylthio prostaglandin derivs
文献作者:Hayashi,M.; Kori,S; Miyake,H; Okada,T.(Ono Pharmaceutical Co.,Ltd.)
参考来源:BE 845348; CH 613950; DE 2637393; FR 2321277; GB 1521747; JP 7725745; NL 7609134; US 4065632; ZA 7604935

Degarelix acetate, FE-200486

地加瑞克Chemical Name: N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-4-[2,6-dioxohexahydropyrimidin-4(S)-ylcarboxamido]-L-phenylalanyl-4-ureido-D-phenylalanyl-L-l...
参考文献标题:GnRH antagonists being modified in positions 5 and 6
文献作者:Jiang,G.; Semple,G.(Ferring BV Group Holding)
参考来源:WO 9846634

ST-126

地塞米松 21-环己烷羧酸酯 17-环丙烷羧酸酯Chemical Name: 21-(Cyclohexylcarbonyloxy)-17alpha-(cyclopropylcarbonyloxy)-9alpha-fluoro-11beta-hydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
CAS No. 132245-57-9
项目整合...
参考文献标题:Novel steroid derivs.
文献作者:Komoto,T.; Okawa,J.; Ogawa,Y.; Sato,S.; Taido,N.; Kuraishi,T.(SSP Co.,Ltd.)
参考来源:EP 0393658; JP 1990279694; US 5063222

Oxazacort, Azacort, Deflazacort, MDL-458, L-5458, DL-458IT, Calcort, Dezacor, Deflan, Flantadin

地夫可特Chemical Name: 11beta,21-Dihydroxy-2'-methyl-5'-betaH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate
CAS No. 14484-47-0
项目整合开发状态: Launched-1985
项目研究机构: Aventis Pharma (Originator)...
参考文献标题:Aclacinomycin A
文献作者:Castar,J.; de Angelis,L.
参考来源:Drugs Fut 1978,3(3),171

Diquafosol tetrasodium, DE-089, U2P4, Up4U, KPY-998, INS-365

地夸磷索四钠地夸磷索 Chemical Name: P1,P4-Di(uridine-5'-tetraphosphate) tetrasodium salt; Uridine-5'-(pentahydrogen tetraphosphate) P'''--5'-ester with uridine tetrasodium salt; P1,P4-Bis(5'uridyl)tetrahydrog...
参考文献标题:Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof
文献作者:Yerxa,B.J.; Pendergast,W.(Inspire Pharmaceuticals,Inc.)
参考来源:JP 2001510484; WO 9905155

Deferasirox, ICL-670A, CGP-72670, ICL-670

地拉罗司Chemical Name: 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
CAS No. 201530-41-8
项目整合开发状态: Phase III
项目研究机构: Novartis (Orphan Drug)
合成路线:Cyclization of salicylamide (I...
参考文献标题:Substd.3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
文献作者:Lattmann,R.; Acklin,P.(Novartis AG)
参考来源:EP 0914118; JP 2000507601; WO 9749395

Carboxyimamidate, Carbetimer, NSC-329514D, NED-137, N-137, Plimar, Polima

地氮铀5-氨甲酰-2-[1-氨甲酰-3-[2,5-二氧基-4-(1-苯乙基)吡咯利丁-3-基]丙基]七铛二酸盐 2-[1-氨基-4-[2,5-二氧基-4-(1-苯乙基)吡咯里丁-3-酰基]-1-氧丁烷-2-基]-5-氨甲酰庚二酸azane Chemical Name: Partially imidized copolymer of ethylene and maleic anhydride; Ma...
参考文献标题:N-137
文献作者:Hopkins,S.J.; Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1983,8(3),210

Desloratadine, Descarboethoxyloratadine, Sch-34117, DCL, Denosin, Clarinex RediTabs, Allex, Desalex, Opulis, Clarinex, Neoclarityn, Aerius

地氯雷他定Chemical Name: 8-Chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
CAS No. 100643-71-8
项目整合开发状态: Launched-2001
项目研究机构: Sepracor (Originator), Schering-Plou...
参考文献标题:Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
文献作者:Villani,F.J.; Wong,J.K.(Schering Corp.)
参考来源:WO 8503707

Deboxamet, ABC-85

地波沙美Chemical Name: 5-Methoxy-2-methyl-3-indolylacetohydroxamic acid; 5-Methoxy-2-methylindole-3-acetohydroxamic acid; N-Hydroxy-5-methoxy-2-methyl-1H-indole-3-acetamide
CAS No. 34024-41-4
项目整合开发...
参考文献标题:ABC-8/5
文献作者:Serradell,M.N.; de Angelis,L.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1982,7(6),371

Darunavir, UIC-94017, TMC-114

地瑞拉韦Chemical Name: N-[3-[N-(4-Aminophenylsulfonyl)-N-isobutylamino]-1(S)-benzyl-2(R)-hydroxypropyl]carbamic acid (3R,3aS,6aR)-perhydrofuro[2,3-b]furan-3-yl ester
CAS No. 206361-99-1
项目整合开发状态: Ph...
参考文献标题:Multi-drug resistant retroviral protease inhibitors and associated methods
文献作者:Hussain,K.A.; Gulnik,S.V.; Ghosh,A.K.; Erickson,J.W.(University of Illinois; US Department of Health & Human Services)
参考来源:WO 9967254