项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Verocainine, Tiapamil hydrochloride, Ro-11-1781/023, Ro-11-1781

噻帕米盐酸盐噻帕米 Chemical Name: 2-(3,4-Dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-1,3-dithiane-2-propanamine-1,1,3,3-tetraoxide hydrochloride
CAS No. 57010-32-9, 57010-31-8 (free base), 8...
参考文献标题:Ro-11,1781
文献作者:Koch,H.
参考来源:Drugs Fut 1979,4(2),122

Tioconazole, UK-20349, Trosyd, Trosyl, Vagistat-1

噻康唑Chemical Name: 1-[2-(2-Chloro-3-thienylmethoxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
CAS No. 65899-73-2
项目整合开发状态: Launched-1982
项目研究机构: Lilly (Originator), Bristol-Myers Squibb (Not D...
参考文献标题:
文献作者:Gymer,G.E.
参考来源:DE 2619381

Setoperone(Rec INN, USAN), R-52245

噻托哌隆Chemical Name: 6-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]-2,3-dihydro-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
CAS No. 86487-64-1
项目整合开发状态: Biological Testing
项目研究机构: Janssen (Originato...
参考文献标题:Bicyclic pyrimidin-5-one derivatives
文献作者:Kennis,L.; Mertens,J.C.(Janssen Pharmaceutica NV)
参考来源:DD 215553; EP 0070053; US 4443451

Tiotropium bromide, BA-679-BR, Spiriva HandiHaler, Spiriva

噻托溴铵噻托溴铵噻托溴铵Chemical Name: (1R,2R,4S,5S,7S)-7-[2-Hydroxy-2,2-di(2-thienyl)acetoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane bromide; 6beta,7beta-Epoxy-3alpha-[2-hydroxy-2,2-di(2-thien...
参考文献标题:Thienylcarboxylic acid ester of aminoalcohols,their quaternary products,their preparation and use of the cpds.
文献作者:Banholzer,R.; Bauer,R.; Reichl,R.(Boehringer Ingelheim GmbH; Boehringer Ingelheim Pharma KG)
参考来源:DE 3931041; EP 0418716; JP 1993502438; US 5610163; WO 9104252

Tioxidazole, Sch-21480

噻昔达唑Chemical Name: N-(6-Propoxybenzothiazol-2-yl)carbamic acid methyl ester
CAS No. 61570-90-9
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepared in four different ways:1) By conden...
参考文献标题:
文献作者:Nafissi-Varchei,M.M.
参考来源:BE 840945; DE 2617198; FR 2308363; JP 76128966; NL 7604149; US 4006242

Tilomisole, NSC-310633, Wy-18251

噻氯咪索Chemical Name: 3-(4-Chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid
CAS No. 58433-11-7
项目整合开发状态: Phase II
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:This compound can be o...
参考文献标题:WY-18,251
文献作者:Castar,J.
参考来源:Drugs Fut 1981,6(8),500

Tiamenidine, Hoe-42-440(HCl), Hoe-440, Symcor, Sundralen

噻美尼定. N-(2-氯-4-甲基-3-噻吩)-4,5-二氢-1H-咪唑-2-胺盐酸盐 Chemical Name: 2-[(2-Chloro-4-methyl-3-thienyl)amino]-2-imidazoline; N-(2-Chloro-4-methyl-3-thienyl)-4,5-dihydro-1H-imidazol-2-amine; 2-(2'-Chloro-4'-methyl...
参考文献标题:Tiamenidine
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1976,1(10),502

Tizolemide, S-730704-B, Hoe-740

噻苯磺胺Chemical Name: 2-Chloro-5-[4-hydroxy-3-methyl-2-(methylimino) 4-thiazolidinyl]benzenesulfonamide; 4-(4-Chloro-3-sulfamoylphenyl)-3-methyl-2-(methylimino)-1,3-thiazolidin-4-ol
CAS No. 56488-58-5...
参考文献标题:Tizolemide
文献作者:Mealey,N.E.; Castar,J.; Blancafort,P.; Lesson,P.A.; Serradell,M.N.
参考来源:Drugs Fut 1981,6(6),371

Sabeluzole, R-58735

噻苯芦索Chemical Name: 1-[4-[N-(2-Benzothiazolyl)-N-methylamino]piperidin-1-yl]-3-(4-fluorophenoxy)propan-2-ol
CAS No. 104383-17-7, 104153-38-0 (deleted CAS)
项目整合开发状态: Phase III
项目研究机构: Janssen (...
参考文献标题:Benzoxazol- and benzothiazolamine derivs.
文献作者:Stokbroekx,R.A.; Luyckx,M.G.M.; Janssens,F.E.(Janssen Pharmaceutica NV)
参考来源:EP 0184257; US 4861785

Tioxamast, F-1865

噻草司特Chemical Name: N-[4-(4-methoxyphenyl)thiazol-2-yl]oxamic acid ethyl ester; 2-[4-(4-Methoxyphenyl)thiazol-2-ylamino]-2-oxoacetic acid ethyl ester
CAS No. 74531-88-7
项目整合开发状态: Phase III
项目研...
参考文献标题:4-Phenyl-2-thiazolyloxamate derivs.,method for their preparation and their application in the treatment of asthma
文献作者:Casadio,S.; Cousse,H.; Tarayre,J.P.; Mouzin,G.(Pierre Fabre S.A.)
参考来源:EP 0006368; ES 481633; FR 2429210; JP 55002684; US 4246271