Tiamenidine, Hoe-42-440(HCl), Hoe-440, Symcor, Sundralen
噻美尼定. N-(2-氯-4-甲基-3-噻吩)-4,5-二氢-1H-咪唑-2-胺盐酸盐 Chemical Name: 2-[(2-Chloro-4-methyl-3-thienyl)amino]-2-imidazoline; N-(2-Chloro-4-methyl-3-thienyl)-4,5-dihydro-1H-imidazol-2-amine; 2-(2'-Chloro-4'-methyl-3'-thienylamino)-1,3-diazacyclopent-2-ene
CAS No. 31428-61-2, 51274-83-0 (monoHCl)
项目整合开发状态: Withdrawn
项目研究机构: Aventis Pharma (Originator), Delalande (Licensee)
合成路线:The reaction of N-(2-chloro-4-methyl-3-thienyl)thiourea (I) with methyl iodide in methanol gives S-methyl-N-(2-chloro-4-methyl-3-thienyl)isothiouronium iodide (II),m.p.113-5 C,which is then condensed with ethylenediamine (A) in methanol at 100 C.
📌 参考资料/链接：
参考文献标题:Tiamenidine
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1976,1(10),502
📄 详细内容
合成路线:The reaction of N-(2-chloro-4-methyl-3-thienyl)thiourea (I) with methyl iodide in methanol gives S-methyl-N-(2-chloro-4-methyl-3-thienyl)isothiouronium iodide (II),m.p.113-5 C,which is then condensed with ethylenediamine (A) in methanol at 100 C.
参考文献标题:2-(Thienyl-3'-amino)1,3-diazacycloalkenes
文献作者:Rippel,R.; et al.
参考来源:DE 1941761; FR 2068493; FR 2068505; GB 1312133; US 3758476
产品链接: CAS No. 31428-61-2›› 产品链接: CAS No.51274-83-0››