Tioxamast, F-1865
噻草司特Chemical Name: N-[4-(4-methoxyphenyl)thiazol-2-yl]oxamic acid ethyl ester; 2-[4-(4-Methoxyphenyl)thiazol-2-ylamino]-2-oxoacetic acid ethyl ester
CAS No. 74531-88-7
项目整合开发状态: Phase III
项目研究机构: Boehringer Ingelheim (Originator), Pierre Fabre (Originator)
合成路线:The cyclization of p-methoxyacetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-(p-methoxyphenyl)-2-aminothiazole (III),which is then reacted with ethoxalyl chloride (IV) in presence of a base to afford F-1865.
📌 参考资料/链接：
参考文献标题:4-Phenyl-2-thiazolyloxamate derivs.,method for their preparation and their application in the treatment of asthma
文献作者:Casadio,S.; Cousse,H.; Tarayre,J.P.; Mouzin,G.(Pierre Fabre S.A.)
参考来源:EP 0006368; ES 481633; FR 2429210; JP 55002684; US 4246271
📄 详细内容
合成路线:The cyclization of p-methoxyacetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-(p-methoxyphenyl)-2-aminothiazole (III),which is then reacted with ethoxalyl chloride (IV) in presence of a base to afford F-1865.
参考文献标题:TIOXAMAST
文献作者:Tarayre,J.P.; Bonnaud,B.
参考来源:Drugs Fut 1990,15(5),469
产品链接: CAS No. 74531-88-7››