Verocainine, Tiapamil hydrochloride, Ro-11-1781/023, Ro-11-1781
噻帕米盐酸盐 噻帕米 Chemical Name: 2-(3,4-Dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-1,3-dithiane-2-propanamine-1,1,3,3-tetraoxide hydrochloride
CAS No. 57010-32-9, 57010-31-8 (free base), 87434-83-1 (monoHCL, monohydrate)
项目整合开发状态: Phase III
项目研究机构: Roche (Originator)
合成路线:3,4-Dimethoxybenzaldehyde (I) is treated with 1,3-propanedithiol (II) to give 2-(3,4-dimethoxyphenyl)-m-dithiane (III),the oxidation product of which (IV) is reacted with N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropanamine chloride (V) in the presence of a base.
📌 参考资料/链接：
参考文献标题:Ro-11,1781
文献作者:Koch,H.
参考来源:Drugs Fut 1979,4(2),122
📄 详细内容
合成路线:3,4-Dimethoxybenzaldehyde (I) is treated with 1,3-propanedithiol (II) to give 2-(3,4-dimethoxyphenyl)-m-dithiane (III),the oxidation product of which (IV) is reacted with N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropanamine chloride (V) in the presence of a base.
参考文献标题:A new Ca2+ antagonist,Ro-111781 and its metabolites.Synthesis and physicochemical properties
文献作者:Ramuz,H.
参考来源:Arzneim-Forsch Drug Res 1978,28(11),2048
合成路线:3,4-Dimethoxybenzaldehyde (I) is treated with 1,3-propanedithiol (II) to give 2-(3,4-dimethoxyphenyl)-m-dithiane (III),the oxidation product of which (IV) is reacted with N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropanamine chloride (V) in the presence of a base.
参考文献标题:
文献作者:Ramuz,H.
参考来源:DE 2460593