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项目整合精选>>>Carboxyimamidate, Carbetimer, NSC-329514D, NED-137, N-137, Plimar, Polima
Carboxyimamidate, Carbetimer, NSC-329514D, NED-137, N-137, Plimar, Polima
地氮铀5-氨甲酰-2-[1-氨甲酰-3-[2,5-二氧基-4-(1-苯乙基)吡咯利丁-3-基]丙基]七铛二酸盐 2-[1-氨基-4-[2,5-二氧基-4-(1-苯乙基)吡咯里丁-3-酰基]-1-氧丁烷-2-基]-5-氨甲酰庚二酸azane Chemical Name: Partially imidized copolymer of ethylene and maleic anhydride; Maleic anhydride polymer with ethylene,reaction product with ammonia
CAS No. 82230-03-3, 74871-30-0 (former CAS registry number), 82115-75-1 (WHO, USAN)
项目整合开发状态: Phase III
项目研究机构: Pfizer (Originator)
合成路线:The copolymerization of ethylene (III) and maleic anhydride (II) in ethylbenzene (I) by means of benzoyl peroxide (IV) at 70 C gives an ethylene/maleic anhydride copolymer (V),which is ammoniated by treating with liquid ammonia in acetone yielding the ammoniated ethylene/maleic acid copolymer (VI).Finally,this product is imidated partially by heating in refluxing xylene.
📌 参考资料/链接：
参考文献标题:N-137
文献作者:Hopkins,S.J.; Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1983,8(3),210
📄 详细内容
合成路线:The copolymerization of ethylene (III) and maleic anhydride (II) in ethylbenzene (I) by means of benzoyl peroxide (IV) at 70 C gives an ethylene/maleic anhydride copolymer (V),which is ammoniated by treating with liquid ammonia in acetone yielding the ammoniated ethylene/maleic acid copolymer (VI).Finally,this product is imidated partially by heating in refluxing xylene.
参考文献标题:Carboxyimidate,a low-molecular-weight polyelectrolyte with antitumor properties and low toxixity
文献作者:Fields,J.E.; Asculai,S.S.; Johnson,J.H.; Johnson,R.K.
参考来源:J Med Chem 1982,25(9),1060-64
产品链接: CAS No. 82230-03-3›› 产品链接: CAS No.74871-30-0››