ST-126

地塞米松 21-环己烷羧酸酯 17-环丙烷羧酸酯Chemical Name: 21-(Cyclohexylcarbonyloxy)-17alpha-(cyclopropylcarbonyloxy)-9alpha-fluoro-11beta-hydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
CAS No. 132245-57-9
项目整合开发状态: Preclinical
项目研究机构: SSP (Originator)
合成路线:Treatment of dexamethasone (I) with trimethyl orthocyclopropanecarboxylate (II) in the presence of p-toluenesulfonic acid gives the mixed orthoester (III),which,upon acidic hydrolysis with oxalic acid leads to the C-17 cyclopropanecarboxylate ester (IV).Subsequent esterification of (IV) with cyclohexanecarbonyl chloride (V) furnishes the desired dexamethasone diester.