Deferasirox, ICL-670A, CGP-72670, ICL-670
地拉罗司Chemical Name: 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
CAS No. 201530-41-8
项目整合开发状态: Phase III
项目研究机构: Novartis (Orphan Drug)
合成路线:Cyclization of salicylamide (I) with salicyloyl chloride (II) by heating at 170 oC provides 2-(2-hydroxyphenyl)-benz[e][1,3]oxazin-4-one (III),which is finally cyclized with 4-hydrazinobenzoic acid (IV) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Substd.3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
文献作者:Lattmann,R.; Acklin,P.(Novartis AG)
参考来源:EP 0914118; JP 2000507601; WO 9749395
📄 详细内容
合成路线:Cyclization of salicylamide (I) with salicyloyl chloride (II) by heating at 170 oC provides 2-(2-hydroxyphenyl)-benz[e][1,3]oxazin-4-one (III),which is finally cyclized with 4-hydrazinobenzoic acid (IV) in refluxing ethanol.
参考文献标题:Deferasirox
文献作者:McIntyre,J.A.; Castar,J.; Mealy,N.E.; Bay閟,M.
参考来源:Drugs Fut 2004,29(4),331
产品链接: CAS No. 201530-41-8››