其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tigogenin CAS Registry Number: 77-60-1 剑麻皂苷元; 剑麻皂甙元; 剑麻皂素

CAS Name: (3b,5a,25R)-Spirostan-3-ol
Percent Composition: C 77.83%, H 10.64%, O 11.52%
Literature References: The aglycon of tigonin; C-5 epimer of smilagenin, q.v. Obtained from leaves of Digitalis lanata Ehrh., Scrophulariaceae: Windhaus, Z. Physiol. Chem. 150, 205 (1925); Jacobs, Fleck, J. Biol. Chem. 88, 545 (1930). From the sisal plant Agave sisalana L., Amaryllidaceae: Rubin, US 2991282 (1961); US 3303187 (1967). Structure: Marker, Rohrmann, J. Am. Chem. Soc. 62, 898 (1940); and synthesis: Mazur, Sondheimer, ibid. 81, 3161 (1959); Caglioti, Magi, Tetrahedron 19, 1127 (1963). In synthesis of steroids: T. Ohta et al., Org. Process Res. Dev. 1, 420 (1997); L. Amiranshvili et al., Bull. Georgian Acad. Sci. 161, 252 (2000).

Digoxigenin CAS Registry Number: 1672-46-4 地黄苷元

CAS Name: (3b,5b,12b)-3,12,14-Trihydroxycard-20(22)-enolide
Additional Names: D20:22-3b,12b,14,21-tetrahydroxynorcholenic acid lactone; lanadigenin
Percent Composition: C 70.74%, H 8.78%, O ...
Literature References: The aglycone of digoxin. By hydrolysis of digoxin: Smith, J. Chem. Soc. 1930, 508. From Digitalis orientalis L. and D. lanata Ehrh., Scrophulariaceae: Mannick, Schneider, Arch. Pharm. 279, 223 (1941); Pataki et al., Helv. Chim. Acta 36, 1295 (1953). Structure: Meyer, Reichstein, Experientia 9, 253 (1953); Cardwell, Smith, ibid. 367; eidem, J. Chem. Soc. 1954, 2012. Synthesis: P. Welzel, H. Stein, Tetrahedron Lett. 22, 3385 (1981).

Sarverogenin CAS Registry Number: 22146-03-8 7beta,8-环氧-3beta,11alpha,14-三羟基-12-氧代-5beta-心甾-20(22)-烯内酯

CAS Name: (3b,5b,7b,11a)-7,8-Epoxy-3,11,14-trihydroxy-12-oxo-card-20(22)-enolide
Percent Composition: C 66.01%, H 7.23%, O 26.76%
Literature References: The aglycone of sarveroside isolated from seeds of Strophanthus spp, Apocynaceae: von Euw et al., Festschrift Prof. Paul Casparis (Zürich, 1949) p 178; Buzas et al., Helv. Chim. Acta 33, 465 (1950); Rothrock et al., J. Am. Chem. Soc. 72, 3827 (1950); von Euw, Reichstein, Helv. Chim. Acta 33, 1006 (1950); Taylor, J. Chem. Soc. 1952, 4832. Structural studies: Taylor, Chem. Ind. (London) 1953, 62; Schindler, Helv. Chim. Acta 39, 375 (1956); Taylor, J. Chem. Soc. C 1966, 790. Revised structure: Fuhrer et al., Helv. Chim. Acta 52, 616 (1969).

a -Phenylacetamide CAS Registry Number: 103-81-1 2-苯乙酰胺

CAS Name: Benzeneacetamide
Additional Names: a-toluamide
Percent Composition: C 71.09%, H 6.71%, N 10.36%, O 11.84%
Literature References: The amide of phenylacetic acid, not to be confused with N-phenylacetamide which is acetanilide. Prepd by Willgerodt reaction from acetophenone or from styrene. Review and lab procedures: Carmack, Spielman in Org. React. II (New York, 1946) p 83. Has also been prepd by heating the ammonium salt of phenylacetic acid: Menschutkin, Ber. 31, 1429 (1898). Lab procedure from benzyl cyanide: Wenner, Org. Synth. coll. vol. IV, 760 (1963).

Diamyl Sodium Sulfosuccinate CAS Registry Number: 922-80-5 磺基琥珀酸-1,4-二戊酯钠盐

CAS Name: Sulfobutanedioic acid 1,4-dipentyl ester sodium salt
Additional Names: sulfosuccinic acid dipentyl ester sodium salt
Trademarks: Aerosol AY; Alphasol AY
Percent Composition: C 4...
Literature References: The amyl or 1-methylbutyl diester of the monosodium salt of sulfosuccinic acid or a mixture of both. Wetting agent prepd by the action of the appropriate alcohols on maleic anhydride followed by addtion of sodium bisulfite: Jaeger, US 2028091 and US 2176423 (1936, 1939 to Am. Cyanamid).

Lead Tetroxide CAS Registry Number: 1314-41-6

Additional Names: Lead oxide red; red lead; minium; lead orthoplumbate; mineral orange; mineral red; Paris red; Saturn red; C.I. Pigment Red 105; C.I. 77578
Percent Composition: O 9.33%, Pb 90....
Literature References: The article of commerce contains about 90% Pb3O4; the remainder being chiefly lead monoxide. Prepn: M. Baudler in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 1963) pp 755-757. Structure: S. T. Gross, J. Am. Chem. Soc. 65, 1107 (1943). Review: Mellor's vol. 7 (1930) pp 672-680. Book: Biologic Effects of Atmospheric Pollutants: Lead (Nat. Acad. Sci., Washington, D.C., 1972) 330 p.

Methyl Abietate CAS Registry Number: 127-25-3 松香甲酯(部分氢化)

Trademarks: Abalyn
Percent Composition: C 79.70%, H 10.19%, O 10.11%
Literature References: The article of commerce is a mixture of the methyl esters of the rosin acids.

Zinc Permanganate CAS Registry Number: 23414-72-4 过锰酸锌

CAS Name: Permanganic acid (HMnO4) zinc salt
Percent Composition: Mn 36.23%, O 42.20%, Zn 21.57%
Literature References: The article of commerce is about 95% pure.

Sodium Bicarbonate CAS Registry Number: 144-55-8 碳酸氢钠

Additional Names: Sodium hydrogen carbonate; sodium acid carbonate; baking soda
Percent Composition: C 14.30%, H 1.20%, Na 27.37%, O 57.13%
Literature References: The bicarbonate of commerce is about 99.8% pure. Prepd from sodium carbonate, water and carbon dioxide. Manuf: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 702-705.

Norgestrel CAS Registry Number: 6533-00-2 炔诺孕酮

CAS Name: (17a)-(±)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-oneTrademarks: Neogest (Schering AG); Ovrette (Wyeth)
Percent Composition: C 80.72%, H 9.03%, O 10.24%
Literature References: The bioactive enantiomer is levorotatory. Prepn: H. Smith, BE 623844 (1963), C.A. 61, 4427c (1964); G. A. Hughes, H. Smith, US 3959322 (1976 to Herchel Smith); H. Smith et al., Experientia 19, 394 (1963); eidem, J. Chem. Soc. 1964, 4472; M. Rosenberger et al., Helv. Chim. Acta 54, 2857 (1971). Comprehensive description: A. M. Sopirak, L. F. Cullen, Anal. Profiles Drug Subs. 4, 294-318 (1975).