Properties: Crystals from methanol, mp 205-207°. uv max (ethanol): 241 nm (e 16700).
Melting point: mp 205-207°
Absorption maximum: uv max (ethanol): 241 nm (e 16700)
Derivative Type: Mixture with ethinyl estradiol
CAS Registry Number: 8056-51-7
Trademarks: Lo/Ovral (Wyeth); Ovral (Wyeth); Stédiril (Wyeth)
Literature References: Clinical efficiacy as oral contraceptive: T. R. Dunson et al., Contraception
48, 109 (1993)
Derivative Type: (+)-Form
CAS Registry Number: 797-64-8
Additional Names: (8a,9b,10a,13a,14b)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one; dextronorgestrel
Literature References: Crystal structure determn: N. J. DeAngelis et al., Acta Crystallogr.
31B, 2040 (1975).
Properties: Crystals, mp 238-242°. [a]D25 +40.7° (CHCl3).
Melting point: mp 238-242°
Optical Rotation: [a]D25 +40.7° (CHCl3)
Derivative Type: (-)-Form
CAS Registry Number: 797-63-7
Additional Names: 17-Ethynyl-18-methyl-19-nortestosterone; 13b-ethyl-17a-ethynyl-17b-hydroxygon-4-en-3-one; levonorgestrel; D-norgestrel; dexnorgestrel (obsolete)
Trademarks: Levonelle (Schering AG); Levonova (Schering AG); Microlut (Schering AG); Microval (Wyeth); Mirena (Schering AG); Norgeston (Schering AG); Norlevo (HRA Pharma); Norplant (Wyeth)
Literature References: Prepn: C. Rufer et al., Ann.
702, 141 (1967); H. Baier et al., Helv. Chim. Acta
68, 1054 (1985). Metabolism: F. Z. Stanczyk, S. Roy, Contraception
42, 67 (1990). Comparative clinical trial with mifepristone, q.v., in emergency contraception: H. von Hertzen et al., Lancet
360, 1803 (2002). Review of clinical pharmacokinetics: K. Fotherby, Clin. Pharmacokinet.
28, 203-215 (1995); of clinical efficacy of subdermal implant: A. J. Coukell, J. A. Balfour, Drugs
55, 861-887 (1998); of intrauterine implant: P. Lähteenmäki et al., Steroids
65, 693-697 (2000); T. Luukkainen, ibid. 699-702.
Properties: Crystals from methanol, mp 235-237°. [a]D20 -32.4° (c = 0.496 in CHCl3). uv max (methanol): 241 nm (e 16770).
Melting point: mp 235-237°
Optical Rotation: [a]D20 -32.4° (c = 0.496 in CHCl3)
Absorption maximum: uv max (methanol): 241 nm (e 16770)
Derivative Type: Mixture of levonorgestrel with ethinyl estradiol
CAS Registry Number: 39366-37-5
Trademarks: Levlen (Berlex); Logynon (Schering AG); Microgynon (Schering AG); Nordette (Wyeth); Ovran (Wyeth); Ovranette (Wyeth); Tetragynon (Schering AG); Tri-Levlen (Berlex); Trinordiol (Wyeth); Triphasil (Wyeth)
Literature References: Clinical trial in acne treatment: L. J. Diaz-Sandoval et al., Fertil. Steril.
76, 461 (2001).
Therap-Cat: Progestogen; oral contraceptive; as contraceptive implant.
Keywords: Contraceptive (Oral); Progestogen.
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