其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Esculetin CAS Registry Number: 305-01-1 秦皮乙素

CAS Name: 6,7-Dihydroxy-2H-1-benzopyran-2-one
Additional Names: 6,7-dihydroxycoumarin; cichorigenin
Percent Composition: C 60.68%, H 3.39%, O 35.93%
Literature References: The aglucon of esculin and of cichoriin. By hydrolysis of esculin or of cichoriin: Merz, Arch. Pharm. 270, 486 (1932). By synthesis: Gattermann, Köbner, Ber. 32, 288 (1899); Bert, Compt. Rend. 214, 230 (1942). Review: Sethna, Shah, Chem. Rev. 36, 1 (1945).

Naringenin CAS Registry Number: 480-41-1 柚皮素; 4',5,7-三羟基黄烷酮

CAS Name: 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 4',5,7-trihydroxyflavanone; naringetol; salipurpol; pelargidanon 1602
Percent Composition: C 6...
Literature References: The aglucon of naringin. Prepn by hydrolysis of naringin: Asahina, Inubuse, Ber. 61, 1514 (1928); Haley, Bassin, J. Am. Pharm. Assoc. 40, 111 (1951). From kino of Eucalyptus maculata Hook, Myrtaceae: Gell et al., Aust. J. Chem. 11, 372 (1958). Synthesis: Rosenmund, Rosenmund, Ber. 61, 2608 (1928); Zemplén, Bognár, Ber. 75, 648 (1942). Absolute configuration: Gaffield, Waiss, Chem. Commun. 1968, 29.

Umbelliferone CAS Registry Number: 93-35-6 伞形花内酯; 7-羟基香豆素

CAS Name: 7-Hydroxy-2H-1-benzopyran-2-one
Additional Names: 7-hydroxycoumarin; hydrangin; skimmetin
Percent Composition: C 66.67%, H 3.73%, O 29.60%
Literature References: The aglucon of skimmin. Present in many plants. Obtained by distillation of resins from umbelliferae: Zwenger, Ann. 115, 1, 15 (1860). Prepn: Bert, Compt. Rend. 214, 230 (1942); Austerweil, ibid. 248, 1810 (1959); Dressler, Reabe, US 3503996 (1970 to Koppers). Main product of metabolism of coumarin in man: Schilling et al., Nature 221, 664 (1969). Metabolism studies of umbelliferone: Indahl, Scheline, Xenobiotica 1, 13 (1971). Use in brain intracellular pH measurements: T. M. Sundt, R.E. Anderson, Brain Res. 186, 355 (1980); eidem, J. Neurophysiol. 44, 60 (1980). Use in fluorescent immunoassays: S. G. Thompson, J. F. Burd, Antimicrob. Agents Chemother. 18, 264 (1980); T. M. Li et al., Anal. Biochem. 118, 102 (1981).

Scopoletin CAS Registry Number: 92-61-5 东莨菪内酯; 莨菪亭

CAS Name: 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one
Additional Names: 7-hydroxy-6-methoxycoumarin; 6-methoxyumbelliferone; b-methylesculetin; chrysatropic acid; gelseminic acid
Percent Compo...
Literature References: The aglucone of scopolin. Occurs in root of Scopolia japonica Maxim., Scopolia carniolica Jacq., Atropa belladonna L., Solanaceae, Convolvulus scammonia L., Convolvulaceae. Isoln: Eykman, Ber. 17 III, 442 (1884). Synthesis: Crosby, J. Org. Chem. 26, 1215 (1961); Desai, Desai, J. Indian Chem. Soc. 40, 456 (1963).

Digitogenin CAS Registry Number: 511-34-2 (25R)-5alpha-螺甾烷-2alpha,3beta,15beta-三醇

CAS Name: (2a,3b,5a,15b,25R)-Spirostan-2,3,15-triol
Percent Composition: C 72.28%, H 9.89%, O 17.83%
Literature References: The aglycon of digitonin: Tschesche, Ber. 68, 1090 (1935); Tschesche, Hagedorn, Ber. 69, 797 (1936). Structure and stereochemistry: Marker et al., J. Am. Chem. Soc. 64, 1843 (1942); Meystre et al., Helv. Chim. Acta 38, 381 (1955). Klass et al., J. Am. Chem. Soc. 77, 3829 (1955); and IR spectra: Djerassi et al., ibid. 78, 3166 (1956).

Digitoxigenin CAS Registry Number: 143-62-4 毛地黄毒苷配基

CAS Name: (3b,5b)-3,14-Dihydroxycard-20(22)-enolide
Additional Names: D20:22-3,14,21-trihydroxynorcholenic acid lactone; cerberigenin; echujetin; evonogenin
Trademarks: Thevetigenin
Perce...
Literature References: The aglycon of digitoxin, thevetin, cerberin, echujin, evomonosid. Prepn by refluxing digitoxin in a mixture of water + alcohol + HCl: Cloetta, Arch. Exp. Pathol. Pharmakol. 88, 113 (1920); Stoll, Kreiss, Helv. Chim. Acta 17, 592 (1934). Structure: Jacobs, Hoffmann, J. Biol. Chem. 67, 333 (1926); Jacobs, Gustus, ibid. 78, 573; 79, 533 (1928); 82, 402 (1929); Jacobs, Elderfield, ibid. 108, 497 (1935); Elderfield, Chem. Rev. 17, 187 (1935). Stereochemistry: Meyer, Helv. Chim. Acta 30, 1976 (1947). Synthesis: Danieli et al., Tetrahedron 22, 3189 (1966); W. Fritsch et al., Ann. 1974, 621; S. F. Donovan et al., Tetrahedron Lett. 1979, 3287; R. Marinibettolo et al., Can. J. Chem. 59, 1403 (1981); T. Milkova et al., Tetrahedron Lett. 23, 413 (1982). Biosynthesis from neriifolin, q.v.: A. Cruz et al., J. Org. Chem. 42, 3580 (1977).

Gitoxigenin CAS Registry Number: 545-26-6 芰皂配基

CAS Name: (3b,5b,16b)-3,14,16-Trihydroxycard-20(22)-enolide
Additional Names: D20,22-3,14,16,21-tetrahydroxynorcholenic acid lactone
Percent Composition: C 70.74%, H 8.78%, O 20.49%
Literature References: The aglycon of gitoxin. By refluxing gitoxin in a mixture of water + alcohol + HCl: Smith, J. Chem. Soc. 1931, 23. Structure: Jacobs, Elderfield, J. Biol. Chem. 100, 671 (1933); Elderfield, Chem. Rev. 17, 217 (1935); Henderson, Chen, J. Med. Pharm. Chem. 5, 988 (1962). Configuration: Moore, Helv. Chim. Acta 37, 659 (1954); Repke, Klesczewski, Arch. Exp. Pathol. Pharmakol. 239, 131 (1960). Cf. ref under Digoxigenin.

Acacetin CAS Registry Number: 480-44-4 金合欢素; 刺槐素

CAS Name: 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 5,7-dihydroxy-4'-methoxyflavone; apigenin-4'-methyl ether
Percent Composition: C 67.60%, H 4.26%, O 28.14%
Literature References: The aglycon of linarin, q.v., and of acaciin. Isoln from linarin: Zemplén, Bognar, Ber. 74B, 1818 (1941). From acaciin: Hattori, Acta Phytochim. 2, 105 (1925). Isoln from Robinia pseudoacacia L., Leguminosae: Nakazawa, Matsuura, J. Pharm. Soc. Jpn. 73, 481 (1953). Structure: Baker et al., J. Chem. Soc. 1951, 691. Synthesis: Robinson, Venkataraman, ibid. 1926, 2348; Zemplén, Bognar, Ber. 76B, 452 (1943); Narasimhachari, Seshadri, Proc. Indian Acad. Sci. 30A, 151 (1949); Simpson, Sci. Proc. R. Dublin Soc. 27, 111 (1956), C.A. 51, 8082a (1957).

Periplogenin CAS Registry Number: 514-39-6 杠柳苷元

CAS Name: (3b,5b)-3,5,14-Trihydroxycard-20(22)-enolide
Additional Names: desoxostrophanthidin
Percent Composition: C 70.74%, H 8.78%, O 20.49%
Literature References: The aglycon of periplocin and periplocymarin; accompanies strophanthidin in Strophanthus eminii Asch. et Pax., Apocynaceae. Isoln: Lehmann, Arch. Pharm. 235, 157 (1897); Jacobs, Hoffmann, J. Biol. Chem. 79, 519 (1928); Stoll, Renz, Helv. Chim. Acta 22, 1193 (1939); Lardon, ibid. 33, 639 (1950). Structure: Speiser, Reichstein, Experientia 3, 323 (1947); eidem, Helv. Chim. Acta 30, 2143 (1947); 31, 622 (1948). Synthesis: Deghenghi, Gaudry, Tetrahedron Lett. 1963, 2045; Kamano et al., J. Org. Chem. 39, 2319 (1974).

Pseudobaptigenin CAS Registry Number: 90-29-9 伪赝靛甙元

CAS Name: 3-(1,3-Benzodioxol-5-yl)-7-hydroxy-4H-1-benzopyran-4-one
Additional Names: 7-hydroxy-3',4'-(methylenedioxy)isoflavone
Percent Composition: C 68.09%, H 3.57%, O 28.34%
Literature References: The aglycon of pseudobaptisin. Prepn by hydrolysis of natural pseudobaptisin: Gorter, Arch. Pharm. 235, 494 (1897). Structure: Späth, Schmidt, Monatsh. Chem. 53, 454 (1929). Syntheses: Späth, Lederer, Ber. 63, 743 (1930); Mahal et al., J. Chem. Soc. 1934, 1771; Baker et al., ibid. 1937, 805; 1953, 1852; Farkas, Ber. 91, 2858 (1958); Dhoubhadel, Joshi, J. Indian Chem. Soc. 52, 440 (1975).