其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Indospicine CAS Registry Number: 16377-00-7 穗花木兰氨酸

CAS Name: (2S)-2,7-Diamino-7-iminoheptanoic acid
Additional Names: L-6-amidinonorleucine; L-2-amino-6-amidinohexanoic acid; L-a-amino-e-amidinocaproic acid
Percent Composition: C 48.54%, H 8...
Literature References: Teratogenic and hepatotoxic factor found in extracts of Indigofera spicata Forsk (Indogofera endecaphylla Jacq.), Leguminosae. Isoln: Hegarty, Pound, Nature 217, 354 (1968). Isoln, structure and biological studies: eidem, Aust. J. Biol. Sci. 23, 831 (1970). Total synthesis: Culvenor et al., Aust. J. Chem. 24, 371 (1971). Review: Hegarty: Australas. J. Dermatol. 14, 35-38 (1973).

Neocembrene CAS Registry Number: 31570-39-5 (1E,5E,9E,12R)-1,5,9-三甲基-12-丙-1-烯-2-基环十四烷并-1,5,9-三烯

CAS Name: (1E,5E,9E,12R)-1,5,9-Trimethyl-12-(1-methylethenyl)-1,5,9-cyclotetradecatriene
Additional Names: cembrene A; neocembrene A
Percent Composition: C 88.16%, H 11.84%
Literature References: Termite trail pheromone with all-trans configuration isolated from Nasutitermes exitiosus (Hill): B. P. Moore, Nature 211, 746 (1966). Structure: A. J. Birch et al., J. Chem. Soc. Perkin Trans. 1 1972, 2653; V. D. Patil et al., Tetrahedron 29, 341 (1973). Synthesis: M. Kodama et al., Tetrahedron Lett. 1975, 3065; Y. Kitahara et al., Chem. Lett. 1976, 219; H. Takayanagi et al., Chem. Commun. 1978, 359. Synthesis of neocembrene and isomers: T. Kato et al., J. Org. Chem. 45, 1126 (1980).

b -Damascenone CAS Registry Number: 23726-93-4; 23696-85-7 (stereo unspecified) 大马士酮

CAS Name: (2E)-1-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one
Additional Names: trans-2,6,6-trimethyl-1-crotonylcyclohexa-1,3-diene
Trademarks: Doricenone (Firmenich)
Percent Co...
Literature References: Terpenic ketone; odorant in fruits, vegetables, honey, wine and beer. Isoln from Bulgarian rose oil, Rosa damascena Mill., and synthesis: E. Demole et al., Helv. Chim. Acta 53, 541 (1970). Synthetic studies: G. Büchi, H. Wüest, ibid. 54, 1767 (1971); K. S. Ayyar et al., J. Chem. Soc. Perkin Trans. 1 1975, 1727. Identification in grapes: T. E. Acree et al., J. Agric. Food Chem. 29, 688 (1981); in tomato volatiles: R. G. Buttery et al., Chem. Ind. (London) 1988, 238. Quantitative determn in foods: A. Sen et al., J. Agric. Food Chem. 39, 757 (1991); in beers: F. Chevance et al., ibid. 50, 3818 (2002). Reactivity in wine: M. A. Daniel et al., ibid. 52, 8127 (2004).

DMMP CAS Registry Number: 756-79-6 甲基膦酸二甲酯

CAS Name: Methylphosphonic acid dimethyl ester
Additional Names: dimethyl methylphosphonate
Percent Composition: C 29.04%, H 7.31%, O 38.68%, P 24.96%
Literature References: Testing chemical to simulate nerve agents such as sarin, q.v. Prepn: T. Milobedzki, K. Szulgin, Chem. Zentralbl. 89, 914 (1918); by photolysis: M. Nakamura et al., J. Chem. Soc. Perkin Trans. 1 1994, 141. Photodestruction: L. J. Radziemski, Jr., J. Environ. Sci. Health B16, 337 (1981). Raman spectroscopic determn: N. Taranenko et al., J. Raman Spectrosc. 27, 379 (1996). Use as simulant in compd destruction study: M. G. Nickelsen et al., J. Adv. Oxid. Technol. 3, 43 (1998). Use as cell volume probe: J. E. Raftos et al., Biochim. Biophys. Acta 968, 160 (1988); J. A. Barry et al., Biochemistry 32, 4665 (1993). Description of use as flame retardant: E. D. Weil in Kirk-Othmer Encyclopedia of Chemical Technology vol. 10 (John Wiley, New York, 4th ed., 1993) pp 976-998. Review of toxicology: J. C. Rowland et al., Health Advisory for Dimethyl Methylphosphonate (DMMP) (PB 93-117018, 1993) 86 pp.

Gratiogenin CAS Registry Number: 7067-16-5 (10alpha,24S)-20,24-环氧-3,25-二羟基-9beta-甲基-19-去甲羊毛甾-5-烯-11-酮

CAS Name: (3b,9b,10a,24S)-20,24-Epoxy-3,25-dihydroxy-9-methyl-19-norlanost-5-en-11-one
Percent Composition: C 76.23%, H 10.24%, O 13.54%
Literature References: Tetracyclic triterpene closely related to the cucurbitacins. Prepd by hydrolysis of gratioside: Retzlaff, Arch. Pharm. 240, 561 (1902). Structural studies: Tschesche, Heesch, Ber. 85, 1067 (1952). Revised structure: Tschesche et al., Ann. 674, 196 (1964).

Limonin CAS Registry Number: 1180-71-8 柠檬苦素

CAS Name: Limonoic acid di-d-lactone
Additional Names: 8-(3-furyl)decahydro-2,2,4a,8a-tetramethyl-11H,13H-oxireno[d]pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione; lim...
Literature References: Tetracyclic triterpenoid; bitter principle of citrus fruits. Isoln: Bernays, Ann. 40, 317 (1841). Improved isoln and purification: P. G. Pifferi et al., Ital. J. Food Sci. 5, 269 (1993). Structure: A. Melera et al., Helv. Chim. Acta 40, 1420 (1957). Stereochemistry: D. Arigoni et al., Experientia 16, 41 (1960); S. Arnott et al., ibid. 49. Partial synthesis: C. Lüthy et al., Helv. Chim. Acta 57, 1060 (1974). HPLC determn in citrus juice: W. W. Widmer, J. Agric. Food Chem. 39, 1472 (1991). Review of chemistry: V. P. Maier et al., ACS Symp. Ser. 143, 63-82 (1980); and removal of juice bitterness: R. F. H. Dekker, Aust. J. Biotechnol. 2, 65 (1988).

Epinastine CAS Registry Number: 80012-43-7 依匹斯汀

CAS Name: 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine
Additional Names: 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepinePercent Composition: C 77.08%, H 6.06%, N 16.85%
Literature References: Tetracyclic, non-sedating histamine H1 receptor antagonist. Prepn: G. Walther et al., GB 2071095; eidem, US 4313931 (1981, 1982 both to Boehringer, Ing.); and receptor binding studies: idem et al., Arzneim.-Forsch. 40, 440 (1990). Pharmacology: A. Fügner et al., ibid. 38, 1446 (1988). Clinical evaluation: W. S. Adamus et al., ibid. 37, 569 (1987). Mechanism of action: K. Tasaka et al., Oyo Yakuri 39, 365 (1990). Toxicology: J. Nishikawa et al., ibid. 42, 151 (1991).

Salen CAS Registry Number: 129409-01-4 (E,E-form); 94-93-9 (unspecified stereo)

CAS Name: (E,E)-2,2'-[1,2-Ethanediylbis(nitrilomethylidyne)]bisphenol
Additional Names: N,N'-bis[(2-hydroxyphenyl)methylene]-1,2-ethanediamine; N,N'-ethylenebis(salicylideneimine); H2sal2en
...
Literature References: Tetradentate Schiff base chelating ligand. Prepn: A. T. Mason, Ber. 20, 267 (1887); and spectral analysis of Cu(II) complex: G. V. Panova et al., J. Gen. Chem. USSR 53, 1452 (1983). Prepn of transition metal complexes: P. Pfeiffer et al., Ann. 505, 84 (1933); and their physicochemical properties: A. Z. El-Sonbati et al., Transition Met. Chem. 17, 66 (1992); M. M. Bhadbhade, D. Srinivas, Inorg. Chem. 32, 6122 (1993). Mass spectra of transition metal complexes: S. M. Schildcrout et al., ibid. 34, 4117 (1995). Thermodynamic properties of salen and its metal complexes: F. Lloret et al., Inorg. Chim. Acta 189, 195 (1991). Use of Mn(III) complex as catalyst in epoxidation of olefins: K. Srinivasan et al., J. Am. Chem. Soc. 108, 2309 (1986); as specific DNA cleaving agent: D. J. Gravert, J. H. Griffin, J. Org. Chem. 58, 820 (1993).

Ethaverine CAS Registry Number: 486-47-5 乙罂粟碱依沙维林

CAS Name: 1-[(3,4-Diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline
Additional Names: 6,7-diethoxy-1-(3,4-diethoxybenzyl)isoquinoline; ethylpapaverine
Trademarks: Dyscural
Percent Compositi...
Literature References: Tetraethyl homolog of papaverine. Synthesis: Wolf, US 1962224 (1934).

Nickel Carbonate Hydroxide CAS Registry Number: 12607-70-4 碱式碳酸镍

Percent Composition: C 3.95%, H 1.33%, Ni 57.90%, O 36.83%
Literature References: Tetrahydrate occurs in nature as the mineral zaratite. Review of toxicology and human exposure: Toxicological Profile for Nickel (PB2006-100005, 2005) 397 pp.