其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Diethylstilbestrol CAS Registry Number: 56-53-1 己烯雌酚

CAS Name: 4,4'[(1E)-1,2-Diethyl-1,2-ethenediyl]bisphenol
Additional Names: (E)-a,a'-diethyl-4,4'-stilbenediol; (E)-3,4-bis(4-hydroxyphenyl)-3-hexene; 4,4'-dihydroxy-a,b-diethylstilbene; stilbes...
Literature References: Synthetic, nonsteroidal estrogen. Prepn: E. C. Dodds et al., Nature 141, 247 (1938); eidem, Proc. R. Soc. London Ser. B 127, 140 (1939). Prepn of ethers: E. E. Reid, E. Wilson, J. Am. Chem. Soc. 64, 1625 (1942). Review of early literature: U. V. Solmssen, Chem. Rev. 37, 481-598 (1945). HPLC determn in plasma and urine: A. T. Rhys Williams et al., J. Chromatogr. 235, 461 (1982). Clinical trial in breast cancer: A. C. Carter et al., J. Am. Med. Assoc. 237, 2079 (1977); in prostate cancer: C. J. Nickel. A. Morales, Can. J. Surg. 26, 434 (1983). Review of metabolism: M. Metzler, Crit. Rev. Biochem. 10, 171-212 (1981). Review of toxicology and use as a growth promotant in livestock: K. E. McMartin et al., J. Environ. Pathol. Toxicol. 1, 279-313 (1978). Book: Developmental Effects of Diethylstilbestrol (DES) in Pregnancy, A. L. Herbst, H. A. Bern, Eds. (Thieme-Verlag, New York, 1981) 203 pp. Comprehensive description: A. A. Al-Badr, A. G. Mekkawi, Anal. Profiles Drug Subs. 19, 145-192 (1990).

Glycopyrrolate CAS Registry Number: 596-51-0 甘罗溴铵

CAS Name: 3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide
Additional Names: 3-hydroxy-1,1-dimethylpyrrolidinium bromide a-cyclopentylmandelate; a-cyclopentylmandelic a...
Literature References: Synthetic, quaternary ammonium anticholinergic. Prepn: Franko, Lunsford, J. Med. Pharm. Chem. 2, 523 (1960); Lunsford, US 2956062 (1960 to A. H. Robins). Pharmacodynamics: E. Kaltiala et al., J. Pharm. Pharmacol. 26, 352 (1974). Toxicology: B. V. Franko et al., Toxicol. Appl. Pharmacol. 17, 361 (1970). Clinical comparison with atropine in anaesthetic practice: F. Kongsrud, S. Sponheim, Acta Anaesthesiol. Scand. 26, 620 (1982); A. I. Webb, R. M. McMurphy, Am. J. Vet. Res. 48, 1733 (1987); B. V. G. Malling et al., Br. J. Anaesth. 60, 426 (1988). Brief review of pharmacology and clinical use: R. K. Mirakhur, J. W. Dundee, Anaesthesia 38, 1195-1204 (1983).

Amiprilose CAS Registry Number: 56824-20-5 盐酸氨普立糖

CAS Name: 3-O-[3-(Dimethylamino)propyl]-1,2-O-(1-methylethylidene)-a-D-glucofuranose
Additional Names: 1,2-O-isopropylidene-3-O-[3'-(N,N-dimethylamino)propyl]-a-D-glucofuranose
Percent Compo...
Literature References: Synthetic, substituted monosaccharide with immunomodulatory activity. Prepn: BE 823313; P. Gordon, US 3939146 (1975, 1976 both to Strategic Med. Res.); E. R. Garrett et al., J. Pharm. Sci. 71, 387 (1982). Absolute configuration: R. J. Linhardt et al., ibid. 79, 158 (1990). HPLC determn in plasma: S. T. Wu et al., J. Chromatogr. B 692, 149 (1997). Clinical pharmacokinetics: E. R. Garrett et al., J. Pharmacokinet. Biopharm. 10, 247 (1982). Clinical trial in rheumatoid arthritis: W. G. Riskin et al., Ann. Intern. Med. 111, 455 (1989). Review of immunoregulatory effects: D. M. Chang, Immunopharmacol. Immunotoxicol. 17, 437-450 (1995).

Hexafluoroacetone CAS Registry Number: 684-16-2 六氟丙酮

CAS Name: 1,1,1,3,3,3-Hexafluoro-2-propanone
Percent Composition: C 21.70%, F 68.66%, O 9.64%
Literature References: Synthon in organic and inorganic reactions with an exceptionally electron deficient carbonyl group. Prepn: N. Fukuhara, L. A. Bigelow, J. Am. Chem. Soc. 63, 788 (1941). Comprehensive review: C. G. Krespan, W. J. Middleton in Fluorine Chem. Rev. vol. 1, P. Tarrant, Ed. (Marcel Dekker, New York, 1967) pp 145-196. Review of reactivity: H. W. Roesky, J. Fluorine Chem. 30, 123-139 (1985); of use in inorganic chemistry: M. Witt et al., Adv. Inorg. Chem. Radiochem. 30, 223-312 (1986); in polymer chemistry: P. E. Cassidy et al., J. Macromol. Sci. Rev. Macromol. Chem. Phys. C29, 365-429 (1989); in peptide chemistry: K. Burger et al., Amino Acids 8, 195-199 (1995); of toxicology: G. L. Kennedy, Jr., Crit. Rev. Toxicol. 21, 149-170 (1990).

Deflazacort CAS Registry Number: 14484-47-0 地夫可特

CAS Name: (11b,16b)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
Additional Names: 11b,21-dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-d...
Literature References: Systemic corticosteroid; oxazoline derivative of prednisolone, q.v. Prepn: G. Nathansohn, G. Winters, BE 679820; eidem, GB 1077393; eidem, US 3436389 (1966, 1967, 1969 all to Lepetit); G. Nathansohn et al., J. Med. Chem. 10, 799 (1967). Pharmacology: P. Schiatti et al., Arzneim.-Forsch. 30, 1543 (1980). Pharmacokinetics: A. Assandri et al., Eur. J. Drug Metab. Pharmacokinet. 5, 207 (1980); eidem, Adv. Exp. Med. Biol. 171, 9 (1984). Immunosuppressive activity in humans: B. H. Hahn et al., J. Rheumatol. 8, 783 (1981). Effect on human mineral metabolism: T. J. Hahn et al., Calcif. Tissue Int. 31, 109 (1980); on human glucose metabolism: P. Cavallo-Perin et al., Eur. J. Clin. Pharmacol. 26, 357 (1984). Clinical comparison with prednisone, q.v., in rheumatoid arthritis and lupus: B. Imbimbo et al., Adv. Exp. Med. Biol. 171, 241 (1984).

Fenpropimorph CAS Registry Number: 67306-03-0 丁苯吗琳

CAS Name: 4-[3-[4-(1,1-Dimethylethyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholineTrademarks: Corbel (BASF); Mistral (M B)
Percent Composition: C 79.15%, H 10.96%, N 4.62%, O 5.27%
Literature References: Systemic fungicide for control of powdery mildew, rust in cereal crops. Prepn, fungicidal activity: W. Himmele et al., DE 2656747 (1978 to BASF), C.A. 89, 109522k (1978). Synthesis using an ionic liquid solvent: S. A. Forsyth et al., Org. Process Res. Dev. 10, 94 (2006). Field trials in control of cereal diseases: J. C. Atkin et al., Proc. Br. Crop Prot. Conf. - Pests Dis. 1981, 307. Inhibition of ergosterol biosynthesis: R. I. Baloch et al., Phytochemistry 23, 2219 (1984). Structure-activity relationships of 3-phenylpropylamines: W. Himmele, E.-H. Pommer, Angew. Chem. Int. Ed. 19, 184 (1980); of substituted morpholines: E.-H. Pommer, Pestic. Sci. 15, 285 (1984). Brief review: K. Bohnen et al., Proc. Br. Crop Prot. Conf. - Pests Dis. 1979, 541-548.

Fosetyl Al CAS Registry Number: 39148-24-8 三乙膦酸铝

CAS Name: Phosphonic acid monoethyl ester aluminum salt
Additional Names: aluminum tris(ethyl phosphite); aluminum tris(O-ethylphosphonate); efosite Al; phosethyl AlTrademarks: Aliette (Bayer C...
Literature References: Systemic fungicide translocated both upwards and downwards in plants. Prepn: V. V. Orlovskii et al., J. Gen. Chem. USSR 42, 1924 (1972). Alternate prepn, fungicidal properties: J. Ducret et al., DE 2456627; eidem, US 4139616 (1975, 1979 both to Rhone-Poulenc); J. Abblard et al., US 4143059 (1979 to Philagro). Biological properties and field trials against vine mildew and other Phycomycetes pathogens: A. Bertrand et al., Phytiatr.-Phytopharm. 26, 3 (1977). Evaluation of carcinogenicity: J. A. Quest et al., Regul. Toxicol. Pharmacol. 14, 3 (1991). Review of properties and fungicidal action on tropical, temperate crops: D. J. Williams et al., Proc. Br. Crop Prot. Conf. - Pests Dis. 1977, 565.

Clopyralid CAS Registry Number: 1702-17-6 3,6-二氯吡啶羧酸

CAS Name: 3,6-Dichloro-2-pyridinecarboxylic acid
Additional Names: 3,6-dichloropicolinic acid; 3,6-DCPPercent Composition: C 37.53%, H 1.57%, Cl 36.93%, N 7.30%, O 16.67%
Literature References: Systemic post-emergence herbicide for use in food crops and mesquite. Prepn: H. Johnston, BE 644105; idem, US 3317549 (1964, 1967 both to Dow). Alternate process: S. D. McGregor, US 4087431 (1978 to Dow). Physicochemical properties, toxicity and herbicidal activity: J. G. Brown, S. D. Uprichard, Proc. Br. Crop Prot. Conf. - Weeds 1976, 119. GLC determn: A. J. Pik, G. W. Hodgson, J. Assoc. Off. Anal. Chem. 59, 264 (1976). Persistence in soil: A. J. Pik et al., J. Agric. Food Chem. 25, 1054 (1977). Field trial in mesquite control: R. W. Bovey, R. E. Meyer, Weed Sci. 33, 349 (1985).

Fenbuconazole CAS Registry Number: 114369-43-6 4-(4-氯苯基)-2-苯基-2-(1H-1,2,4-三唑-1-甲基)丁腈

CAS Name: a-[2-(4-Chlorophenyl)ethyl]-a-phenyl-1H-1,2,4-triazole-1-propanenitrile
Additional Names: (R,S)-4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butyronitrile; fenethanilT...
Literature References: Systemic triazole antifungal for food and ornamental crops. Prepn: S. H. Shaber et al., DE 3721786; idem, US 5087635 (1988, 1992 both to Rohm Haas). Comprehensive description: D. Driant et al., Brighton Crop Prot. Conf. - Pests Dis. 1988, 33-40. Field trials vs Botrytis infection in roses: Y. Elad et al., Crop Prot. 12, 69 (1993); vs root rot in barley: P. J. Cotterill, ibid. 273.

Fenamidone CAS Registry Number: 161326-34-7 咪唑菌酮

CAS Name: (5S)-3,5-Dihydro-5-methyl-2-(methylthio)-5-phenyl-3-(phenylamino)-4H-imidazol-4-one
Additional Names: (S)-1-anilino-4-methyl-2-methylthio-4-phenylmidazolin-5-oneTrademarks: Reason (Ba...
Literature References: Systemic, broad spectrum fungicide; mitochondrial electron transport inhibitor. Prepn: G. Lacroix et al., EP 551048; eidem, US 6002016 (1993, 1999 both to Rhone-Poulenc). Physical and biological properties: R. T. Mercer et al., Brighton Crop Prot. Conf. - Pests Dis. 1998, 319. Greenhouse studies: M. P. Latrose et al., ibid. 863. Field trials: G. DeWever et al., Meded. Fac. Landbouwwet. Univ. Gent 65, 807 (2000).