其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Resmethrin CAS Registry Number: 10453-86-8 苄蚨菊酯

CAS Name: 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid [5-(phenylmethyl)-3-furanyl]methyl ester
Additional Names: 5-benzyl-3-furanmethanol-2,2-dimethyl-3-(2-methylpropenyl) c...
Literature References: Synthetic pyrethroid insecticide. Prepn: M. Elliott, GB 1168797; idem, US 3465007 (both 1969 to Natl. Res. Dev. Corp.); idem et al., Nature 213, 493 (1967). GLC determn in corn, cornmeal, flour, wheat: R. A. Simonaitis, R. S. Cail, J. AOAC 58, 1032 (1975); and infrared spec in nonaqueous aerosols: M. W. Law J. AOAC Int. 59, 745 (1976). LC determn in urine and water: B. L. Loper, K. A. Anderson, ibid. 86, 1236 (2003). Photodecomposition: K. Ueda et al., J. Agric. Food Chem. 22, 212 (1974). Environmental fate and ectoxicological effects in aquatic systems: G. M. Rand, Ecotoxicology 11, 101 (2002). Efficacy against greenhouse pests: R. E. Webb et al., J. Econ. Entomol. 67, 295 (1974); against Anopheles quadrimaculatus: C. A. Sandoski et al. ibid, 76, 646 (1983). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Bioresmethrin CAS Registry Number: 28434-01-7 生物苄呋菊酯

CAS Name: (1R,3R)-2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid [5-(phenylmethyl)-3-furanyl]methyl ester
Additional Names: trans-(+)-2,2-dimethyl-3-(2-methylpropenyl)cycloprop...
Literature References: Synthetic pyrethroid insecticide. Prepn: M. Elliott, N. F. Janes, FR 1503260; eidem, US 3465007 and US 3542928 (1967, 1969, 1970, all to Nat. Res. Dev. Corp.). Insecticidal activity: M. Elliott et al., Nature 213, 493 (1967); idem, et al., Pestic. Sci. 2, 243 (1971). Mammalian metabolism: C. O. Abernathy, J. E. Casida, Science 179, 1235 (1973). Control of cockroaches: P. R. Chadwick et al., J. Med. Entomol. 13, 625 (1977). Acute toxicity: T. B. Gaines, R. E. Linder, Fundam. Appl. Toxicol. 7, 299 (1986). Brief review: D. S. Gunew, Anal. Methods Pestic. Plant Growth Regul. 10, 19-29 (1978). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Tefluthrin CAS Registry Number: 79538-32-2 七氟菊酯

CAS Name: (1R,3R)-rel-3-[(1Z)-2-Chloro-3,3,3-trifluoro-1-propenyl]-2,2-dimethylcyclopropanecarboxylic acid (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester
Additional Names: (±)-cis-4-meth...
Literature References: Synthetic pyrethroid insecticide. Prepn: N. Punja, EP 31199; idem, US 4405640 (1981, 1983 both to ICI). Evaluation as seed treatment: G. J. Marrs, R. F. S. Gordon, Br. Crop Prot. Counc. Monogr. 39, 17 (1988); for sugar beet: D. Cooke et al., Br. Sugar Beet Rev. 59, 30 (1991). Effects on non-target organisms: J. M. Coulson et al., Brighton Crop Prot. Conf. - Pests Dis. 1990, 975; A. M. Dewar et al., ibid. 987. Review of properties and insecticidal activity: M. Konradt, C. Hemmen, Gesunde Pflanz. 44, 64-68 (1992); of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Flumethrin CAS Registry Number: 69770-45-2 氟氯苯菊酯

CAS Name: 3-[2-Chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropanecarboxylic acid cyano(4-fluoro-3-phenoxyphenyl)methyl ester
Additional Names: 3'-phenoxy-4'-fluoro-a-cyanobenzyl 2,2-dim...
Literature References: Synthetic pyrethroid insecticide. Prepn: R. Fuchs et al., DE 2730515; eidem, US 4276306 (1979, 1981 both to Bayer). Series of articles on laboratory evaluation, efficacy and toxicology: Vet. Med. Rev. 2, 115-139, 158-177 (1982).

Cyhalothrin CAS Registry Number: 68085-85-8 氯氟氰菊酯

CAS Name: 3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester
Trademarks: Grenade (Zeneca)
Percent Composition: C 61.41%, H 4.2...
Literature References: Synthetic pyrethroid insecticide. Prepn: R. K. Huff, DE 2802962; idem, US 4183948 (1977, 1980 both to ICI). Activity: P. D. Bently et al., Pestic. Sci. 11, 156 (1980); V. K. Stubbs et al., Aust. Vet. J. 59, 152 (1982). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Cyphenothrin CAS Registry Number: 39515-40-7 右旋苯醚氰菊酯

CAS Name: 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester
Additional Names: (RS)-a-cyano-3-phenoxybenzyl (1R)-cis,trans-chrysanthemate; a-cyan...
Literature References: Synthetic pyrethroid. Prepn: T. Matsuo et al., DE 2231312; eidem, US 3835176 (1973, 1974 to Sumitomo). Insecticidal activity: M. Elliot et al., Pestic. Sci. 13, 407 (1982); T. Matsunaga et al., Pesticide Chemistry: Human Welfare and the Environment 2, J. Miyamoto et al., Eds (Pergamon Press, Oxford, 1983) pp 231-238; T. Itoh et al., J. Am. Mosq. Control Assoc. 2, 503 (1986). Mechanism of action: T. Narahashi, Neurobehav. Toxicol. Teratol. 4, 753 (1982). Series of articles on stereoselective syntheses of labelled cis and trans forms: H. Kanamaru et al., Radioisotopes 35, 103, 109, 242 (1986).

Prallethrin CAS Registry Number: 23031-36-9 炔丙菊酯

CAS Name: 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid 2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl ester
Additional Names: (S)-2-methyl-4-oxo-3-(2-propynyl)cyclopent-2-e...
Literature References: Synthetic pyrethroid; propynyl analog of allethrin. The commercial product is a mixture of the ester of the (4S)-alcohol with the (1R)-cis/trans-chrysanthemic acids; the trans isomer is the most bioactive. Initial report: W. A. Gersdorff, P. G. Piquett, J. Econ. Entomol. 54, 1250 (1961). Synthesis and resolution of labelled commerical isomers: H. Kanamaru et al., J. Labelled Compd. Radiopharm. 23, 995 (1986). Pharmacology: T. Segawa et al., Oyo Yakuri 34, 181 (1987). Insecticidal activity: T. Matsunaga et al., Jpn. J. Sanit. Zool. 38, 219 (1987). Efficacy against mosquitoes: R. L. Groves et al., J. Am. Mosq. Control Assoc. 13, 184 (1997). Review of biological activity: Y. Abe et al., Brighton Crop Prot. Conf. - Pests Dis. 1994, 1023. Brief review of structure-activity: N. Matsuo, Pestic. Sci. 52, 21-28 (1998).

Propantheline Bromide CAS Registry Number: 50-34-0 溴丙胺太林

CAS Name: N-Methyl-N-(1-methylethyl)-N-[2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl]-2-propanaminium bromide
Additional Names: (2-hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate...
Literature References: Synthetic quaternary ammonium anticholinergic. Prepn: Cusic, Robinson, J. Org. Chem. 16, 1921 (1951); US 2659732 (1953 to Searle). Metabolic studies: Beermann et al., Clin. Pharmacol. Ther. 13, 212 (1972).

Tamibarotene CAS Registry Number: 94497-51-5 他米巴罗汀

CAS Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
Additional Names: p-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylcarbamoyl)benzoic acidTrad...
Literature References: Synthetic retinoic acid receptor-a/b-selective retinoid. Prepn: K. Shudo, EP 170105 (1986 to Sumitomo; Yoshitomi); idem, US 4703110 (1987); H. Kagechika et al., J. Med. Chem. 31, 2182 (1988). HPLC determn in plasma: M. Itoh, G. Kominami, J. Immunoassay Immunochem. 22, 213 (2001). Receptor binding studies in human leukemia cells: Y. Hashimoto et al., Jpn. J. Cancer Res. 79, 473 (1988). Series of articles on pharmacokinetics and reproductive and developmental toxicity: K. Mizojiri et al., Arzneim.-Forsch. 47, 59, 195, 201, 259, 270 (1997). Inhibition of myeloma cell-induced angiogeneis: T. Sanda et al., Leukemia 19, 901 (2005). Clinical evaluation in acute promyelocytic leukemia: K. Shinjo et al., Int. J. Hematol. 72, 470 (2000).

Perflubron CAS Registry Number: 423-55-2 全氟溴辛烷

CAS Name: 1-Bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
Additional Names: bromoperfluorooctane; perfluoroctyl bromide; PFOBTrademarks: Imagent (Alliance); LiquiVent (Alliance)...
Literature References: Synthetic second generation brominated fluorocarbon. Prepd not claimed: FR 1512068; L. A. Loree, US 3456024 (1968, 1969 both to Dow Corning). Radiopacity and toxicology: D. M. Long et al., Radiology 105, 323 (1972). Biodistribution and determn in plasma and tissue: F. H. Lee et al., J. Pharm. Sci. 67, 1038 (1978). Clinical trial in abdominal imaging: R. F. Mattrey, Radiology 191, 841 (1994). Toxicity studies: A. R. Burgan et al., Biomater. Artif. Cells Artif. Organs 16, 681 (1988). Review of physicochemical properties and therapeutic potential: D. M. Long et al., ibid. 411-420; of oxygen delivery characteristics: J. G. Riess, ibid. 20, 183-202 (1992).