其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cuelure CAS Registry Number: 3572-06-3 4-(4-乙酰氧基苯基)-2-丁酮

CAS Name: 4-[4-(Acetyloxy)phenyl]-2-butanone
Additional Names: 4-(p-hydroxyphenyl)-2-butanone acetate
Percent Composition: C 69.88%, H 6.84%, O 23.27%
Literature References: Synthetic sex pheromone developed as a lure for melon flies, Dacus cucurbitae (Coq.); analog of raspberry ketone. Prepn and biological activity: M. Beroza et al., Science 131, 1044 (1960); B. H. Alexander et al., J. Agric. Food Chem. 10, 270 (1962). Extraction and GC-MS determn in soil: J. P. Alcantara-Licudine et al., J. Chromatogr. Sci. 34, 238 (1996). Field studies in fruit fly eradication: R. T. Cunningham, L. F. Steiner, J. Econ. Entomol. 65, 505 (1972). Acute toxicity study: M. Beroza et al., Toxicol. Appl. Pharmacol. 31, 421 (1975).

Trimedlure CAS Registry Number: 12002-53-8 诱蝇羧酯

CAS Name: 4(or 5)-Chloro-2-methylcyclohexanecarboxylic acid, 1,1-dimethylethyl ester
Additional Names: tert-butyl 4(or 5)-chloro-2-methylcyclohexanecarboxylate
Percent Composition: C 61.92%,...
Literature References: Synthetic sex pheromone developed as attractant for the Mediterranean fruit fly, or medfly, Ceratitis capitata (Weidemann). Prepn and physical props: M. Beroza et al., J. Agric. Food Chem. 9, 361 (1961). Commercial product consists mainly of the four isomers having the methyl and ester substituents on the ring in a trans configuration. Separation and identification of isomers: T. P. McGovern, M. Beroza, J. Org. Chem. 31, 1472 (1966). Extension of activity by fixatives: eidem, J. Econ. Entomol. 60, 379 (1967). Controlled release: S. Nakagawa et al., ibid. 72, 625 (1979). Repellent effect of high concns: eidem, ibid. 64, 762 (1971). Rate of loss from wicks: J. R. King, P. J. Landolt, ibid. 77, 221 (1984). Acute toxicity studies: M. Beroza et al., Toxicol. Appl. Pharmacol. 31, 421 (1975).

Hexalure CAS Registry Number: 23192-42-9 (Z)-十六碳-7-烯基乙酸酯

CAS Name: (Z)-7-Hexadecen-1-ol acetate
Additional Names: cis-7-hexadecenyl acetate; cis-1-acetoxy-7-hexadecene; hexalene
Percent Composition: C 76.54%, H 12.13%, O 11.33%
Literature References: Synthetic sex pheromone for pink bollworm moths, Pectinophora gossypiella (Saunders). Discovery and prepn: N. Green et al., Experientia 25, 682 (1969); N. Green, J. C. Keller, DE 1960155; eidem, US 3586712 (1970, 1971 both to U.S. Sec. Agric.). Field trials: J. C. Keller et al., J. Econ. Entomol. 62, 1520 (1969). Acute toxicity study: M. Beroza et al., Toxicol. Appl. Pharmacol. 31, 421 (1975). See also Gossyplure, Propylure.

Reversine CAS Registry Number: 656820-32-5 N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺

CAS Name: N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine
Additional Names: 2-(4-morpholinoanilino)-6-cyclohexylaminopurine; 2-(4-morpholinoanilino)-N6-cyclohexyladenine
Per...
Literature References: Synthetic small molecule reported to induce murine myoblasts to dedifferentiate into multipotent progenitor cells. Discovery of induction of cell dedifferentiation: S. Chen et al., J. Am. Chem. Soc. 126, 410 (2004). Prepn: S. Chen et al., WO 05047524; eidem, US 050176707 (both 2005 to Scripps); see also combinatorial synthesis method: S. Ding et al., J. Am. Chem. Soc. 124, 1594 (2002). A3 adenosine receptor antagonist activity: M. Perreira et al., J. Med. Chem. 48, 4910 (2005).

Argatroban CAS Registry Number: 74863-84-6 阿加曲班(MCI-9038)

CAS Name: (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Additional Names: (2R,4R)-4...
Literature References: Synthetic thrombin inhibitor. Prepn of argatroban and stereoisomers: R. Kikumoto et al., EP 8746; S. Okamoto et al., US 4258192 (1980, 1981 both to Mitsubishi Chem. Ind.); S. Okamoto et al., Biochem. Biophys. Res. Commun. 101, 440 (1981). Comparison with heparin, q.v., of antithrombotic effect in animals: T. Kumada, Y. Abiko, Thromb. Res. 24, 285 (1981). Stereoselective inhibition of thrombin: R. Kikumoto et al., Biochemistry 23, 85 (1984). Clinical evaluation in hemodialysis: K. Ota et al., Proc. Eur. Dial. Transplant. Assoc. 20, 144 (1983); in disseminated intravascular coagulation: K. Kumon et al., Crit. Care Med. 12, 1039 (1984).

Trioxsalen CAS Registry Number: 3902-71-4 三甲沙林

CAS Name: 2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
Additional Names: 6-hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid d-lactone; 4,5',8-trimethylpsoralenTrademarks: Trisoralen (Valea...
Literature References: Synthetic trimethyl psoralen deriv. Prepn: K. D. Kaufman, J. Org. Chem. 26, 117 (1961); US 3201421 (1965). Protective effect vs UV-B erythema: P. G. Agache, L. Coupez, Arch. Dermatol. Res. 268, 85 (1980). Clinical study: N. Vaatainen et al., Clin. Exp. Dermatol. 6, 133 (1981). Comprehensive description: M. M. A. Hassan, M. A. Loutfy, Anal. Profiles Drug Subs. 10, 705-727 (1981). See also Psoralen, Methoxsalen.

Doxercalciferol CAS Registry Number: 54573-75-0 度骨化醇

CAS Name: (1a,3b,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol
Additional Names: 1a-hydroxyvitamin D2; 1-hydroxyergocalciferol
Trademarks: Hectorol (Bone Care)
Percent Compo...
Literature References: Synthetic vitamin D prohormone. Prepn: H.-Y. P. Lam et al., Science 186, 1038 (1974); eidem, Steroids 30, 671 (1977); H. E. Paaren et al., J. Org. Chem. 45, 3253 (1980). Comparative activity and toxicity: G. Sjöden et al., Proc. Soc. Exp. Biol. Med. 178, 432 (1985). Metabolism to bioactive form: J. C. Knutson et al., Endocrinology 136, 4749 (1995). Pharmacology: J. W. Coburn et al., Nephrol. Dial. Transplant. 11, Suppl. 3, 153 (1996). Clinical trial for suppression of secondary hyperparathyroidism in hemodialysis: J. M. Frazao et al., ibid. 13, Suppl. 3, 68 (1998).

Iso E Super® (Int. Flavors & Fragrances) CAS Registry Number: 54464-57-2 (unspecified); 59056-94-9 (trans-form)

CAS Name: 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone
Percent Composition: C 81.99%, H 11.18%, O 6.83%
Literature References: Synthetic woody odorant. Prepn: J. B. Hall, J. M. Sanders, DE 2408689; eidem, US 3911018 (1974, 1975 both to Int. Flavor Fragrance). Patch testing for contact allergies: P. J. Frosch et al., Contact Dermatitis 33, 333 (1995). Adherence and duration to fabric: S. Widder, Dragoco Rep. 1999, 69. Isoln of major odor producing "impurity": C. Nussbaumer et al., Helv. Chim. Acta 82, 1016 (1999). Brief description: M. Gras, Perfum. Flavor. 17, 2-12 (1992). Review of synthesis and use: G. Fráter et al., Tetrahedron 54, 7633-7703 (1998).

Elcometrine CAS Registry Number: 7759-35-5 醋酸烯诺孕酮

CAS Name: 17-(Acetyloxy)-16-methylene-19-norpregn-4-ene-3,20-dione
Additional Names: 16-methylene-17a-hydroxy-19-nor-4-pregnene-3,20-dione 17-acetate; 16-methylene-17a-acetoxy-19-norpregn-4-ene...
Literature References: Synthetic, non-orally active progestin. Prepn: V. Schwarz et al., Tetrahedron Lett. 1967, 1925; eidem, Collect. Czech. Chem. Commun. 33, 4337 (1968). Pharmacology: N. Kumar et al., Steroids 65, 629 (2000). Clinical pharmacokinetics: G. Noé et al., Contraception 48, 548 (1993). Metabolism: O. Heikinheimo et al., ibid. 50, 275 (1994). Clinical trial of subdermal implant: S. Diaz et al., ibid. 51, 33 (1995). Clinical trial of vaginal rings delivery system: I. Sivin et al., ibid. 69, 137 (2004); idem et al., ibid. 71, 122 (2005).

Fosfestrol CAS Registry Number: 522-40-7 乙烯雌酚二磷酸酯

CAS Name: 4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bisphenol bis(dihydrogen phosphate)
Additional Names: a,a'-diethyl-4,4'-stilbenediol diphosphoric acid ester; diethylstilbestrol diphosphate; die...
Literature References: Synthetic, nonsteroidal estrogen. Prepd by treating stilbestrol with phosphorus oxychloride in pyridine: Miescher, Heer, US 2234311 (1941); Arnold, US 2802854 (1957 to Asta-Werke). Prepn of stable solns at pH 10: Fonner, Collins, US 2828244 (1958 to Miles Labs.). Prepn of sodium salts: Dawson, US 2971975 (1961 to Miles Labs.). Clinical pharmacokinetics: H. Oelschläger et al., Arzneim.-Forsch. 36, 1284 (1986). Review of clinical trials in prostate cancer: J-P. Droz et al, Cancer 71, 1123-1130 (1993).