其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Benexate Hydrochloride CAS Registry Number: 78718-25-9 苯甲酸,2-[[反式-4-[[(氨基亚氨基)氨基]甲基]环己基]羰基]氧]-,苯甲基酯,盐酸一酸盐(9CI)

CAS Name: 2-[[[trans-4-[[(Aminoiminomethyl)amino]methyl]cyclohexyl]carbonyl]oxy]benzoic acid phenylmethyl ester monohydrochloride
Additional Names: benzyl salicylate trans-4-(guanidinomethyl)cy...
Literature References: Synthetic protease inhibitor with antiulcer activity. Prepn: BE 885263; M. Muramatsu et al., US 4348410 (1981, 1982 to Nippon Chemiphar; Teikoku Chem. Ind.). Prepn and protease inhibition: T. Satoh et al., Chem. Pharm. Bull. 33, 647 (1985). Prepn of the clathrate compound with b-cyclodextrin: JP Kokai 83 38250; M. Shinoda et al., US 4478995 (1983, 1984 both to Teikoku Chem. Ind.). Effect on gastric secretion and exptl ulcers in rats: S. Okabe et al., Oyo Yakuri 27, 829 (1984), C.A. 101, 143881c (1984); I. Tanaka, H. Tagami, Nippon Yakurigaku Zasshi 85, 167 (1985), C.A. 103, 64660t (1985); F. Hirose et al., Yakuri to Chiryo 15, 4749 (1987), C.A. 108, 137769a (1988).

Leteprinim CAS Registry Number: 138117-50-7 苯甲酸,4-[[3-(1,6-二氢-6-氧-9H-普林-9-基)-1-氧丙基]氨基]-

CAS Name: 4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic acid
Percent Composition: C 55.05%, H 4.00%, N 21.40%, O 19.55%
Literature References: Synthetic purine derivative with neuroprotective effects. Prepn: A. J. Glasky, WO 9114434 (1991); idem, US 5091432 (1992). Effect on working memory in mice: idem et al., Pharmacol. Biochem. Behav. 47, 325 (1994). Mode of action study: P. J. Middlemiss et al., Neurosci. Lett. 199, 131 (1995). Mechanism of brain efflux: R. Yan, E. M. Taylor, Drug Metab. Dispos. 30, 513 (2002). Reviews of pharmacology: M. P. Rathbone et al., Drug Dev. Res. 45, 356-372 (1998); idem et al., Expert Opin. Invest. Drugs 8, 1255-1262 (1999).

Acrinathrin CAS Registry Number: 101007-06-1 氟丙菊酯

CAS Name: (1R,3S)-2,2-Dimethyl-3-[(1Z)-3-oxo-3-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]-1-propenyl]cyclopropanecarboxylic acid (S)-cyano(3-phenoxyphenyl)methyl ester
Additional Names: (S)-a-...
Literature References: Synthetic pyrethroid acaricide. Prepn: J. Martel et al., FR 2486073; eidem, US 4542142 (1982, 1985 both to Roussel-UCLAF); J. R. Tessier et al., in Pesticide Chemistry: Human Welfare and the Environment vol. 1, J. Miyamoto, P. C. Kearney, Eds. (Pergamon Press, Oxford, 1983) pp 95-100. Field trial vs spider mite: B. H. Labanowska, C. Tkaczuk, Fruit Sci. Rep. 18, 185 (1991). Review: J. J. Heller et al., Meded. Fac. Landbouwwet. Univ. Gent 57, 931-939 (1992).

Fenpropathrin CAS Registry Number: 39515-41-8 甲氰菊酯

CAS Name: 2,2,3,3-Tetramethylcyclopropane carboxylic acid cyano(3-phenoxyphenyl)methyl ester
Additional Names: a-cyano-3-phenoxybenzyl 2,2,3,3-tetramethylcyclopropanecarboxylate; fenpropanateTr...
Literature References: Synthetic pyrethroid insecticide with repellant and contact activity. Prepn: T. Matsuo et al., DE 2231312; eidem, US 3835176 (1973, 1974 to Sumitomo). Commercial product is mixture of stereoisomers, the (S)-isomer primarily responsible for the bioactivity. Separation of enantiomers by chiral phase HPLC: R. A. Chapman, J. Chromatogr. 258, 175 (1983). Pesticidal activity: M. H. Breese, Pestic. Sci. 8, 264 (1977). Metabolism: M. J. Crawford, D. H. Hutson, ibid. 579. Degradn in soil: T. R. Roberts, M. E. Standen, ibid. 600; R. A. Chapman, Bull. Environ. Contam. Toxicol. 26, 513 (1981). Fish toxicity: J. R. Coats, ibid. 23, 250 (1979). Mammalian toxicity study: R. D. Verschoyle, W. N. Aldridge, Arch. Toxicol. 45, 325 (1980). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Fenvalerate CAS Registry Number: 51630-58-1 氰戊菊酯

CAS Name: 4-Chloro-a-(1-methylethyl)benzeneacetic acid cyano(3-phenoxyphenyl)methyl ester
Additional Names: a-cyano-3-phenoxybenzyl a-(4-chlorophenyl)isovalerate; cyano(3-phenoxyphenyl)methyl 4...
Literature References: Synthetic pyrethroid insecticide without the usual cyclopropane ring. Prepn: DE 2335347; K. Fujimoto et al., US 3996244 (1974, 1976, both to Sumitomo); D. A. Wood, DE 2651341; idem, US 4061664 (1977, both to Shell). Has two chiral centers giving four possible optical isomers; prepn and comparative insecticidal activity of isomers: M. Hirano et al., DE 2737297; eidem, US 4503071 (1978, 1985 both to Sumitomo). Absolute configuration of most active isomer, esfenvalerate: K. Aketa et al., Agric. Biol. Chem. 42, 895 (1978). GC separation of isomers: G. R. Cayley, B. W. Simpson, J. Chromatogr. 356, 123 (1986); determn of esfenvalerate in technical prepn: S. Sakaue et al., Agric. Biol. Chem. 51, 1671 (1987). Comprehensive description of activity and physical properties of esfenvalerate: H. Oo'uchi, Jpn. Pestic. Inf. 1985, 21-24. Comparative soil metabolism of isomers: P.W. Lee et al., J. Agric. Food Chem. 35, 384 (1987). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Fluvalinate CAS Registry Number: 69409-94-5 尖顶的四面体窑具

CAS Name: N-[2-Chloro-4-(trifluoromethyl)phenyl]-DL-valine cyano(3-phenoxyphenyl)methyl esterTrademarks: Mavrik (Zoecon)
Percent Composition: C 62.09%, H 4.41%, Cl 7.05%, F 11.33%, N 5.57%, O 9...
Literature References: Synthetic pyrethroid insecticide without the usual cyclopropane ring. Prepn: C. A. Henrick, B. A. Garcia, DE 2812169 (1978 to Zoecon), C.A. 90, 122072d (1970). Activity: C. A. Henrick et al., Pestic. Sci. 11, 224 (1980). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Cypermethrin CAS Registry Number: 52315-07-8 氯氰菊酯

CAS Name: 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester
Additional Names: (±)-a-cyano-3-phenoxybenzyl-(±)-cis,trans-3-(2,2-dichlor...
Literature References: Synthetic pyrethroid insecticide, usually exists as a mixture of cis and trans isomers. Prepn of racemic mixture: M. Elliot et al., DE 2326077; eidem, US 4024163 (1974, 1977 to NRDC). Activity: eidem, Pestic. Sci. 6, 537 (1975); M. H. Breese, ibid. 8, 264 (1977). Soil degradation: T. R. Roberts, M. E. Standen, ibid. 305; D. D. Kaufman et al., J. Agric. Food Chem. 29, 239 (1981). Metabolism: T. Shono et al., ibid. 27, 316 (1979); M. J. Crawford et al., ibid. 29, 130 (1981). Analysis: A. Sapiets et al., Anal. Methods Pestic. Plant Growth Regul. 13, 33-51 (1984). Repellent activity against flies on cattle: J. A. Shemanchuk, Pestic. Sci. 12, 412 (1981); J. E. Hillerton et al., Br. Vet. J. 141, 160 (1985). Acute toxicity study: F. Cantalamessa, Arch. Toxicol. 67, 510 (1993). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Cyfluthrin CAS Registry Number: 68359-37-5 氟氯氰菊酯

CAS Name: 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid cyano(4-fluoro-3-phenoxyphenyl)methyl ester
Additional Names: (R,S)-a-cyano-4-fluoro-3-phenoxybenzyl-(1R,S)-cis,trans-3...
Literature References: Synthetic pyrethroid insecticide. Commercial product is mixture of 8 isomers, the (1R)-isomers primarily responsible for the bioactivity. Prepn of racemic mixture: R. Fuchs et al., DE 2709264; eidem, US 4218469 (1978, 1980 both to Bayer AG). Prepn of stereoisomers: eidem, EP 22970; eidem, US 4287208 (both 1981 to Bayer AG). Chiral phase HPLC separation of enantiomers: R. A. Chapman, J. Chromatogr. 258, 175 (1983). Metabolism by cell suspension cultures: U. Preiss et al., Chemosphere 13, 861 (1984). Field evaluation against cotton insect pests: J. A. Durant, J. Agric. Entomol. 1, 201 (1984). Review of chemistry, bioactivity and field studies: I. Hammann, R. Fuchs, Pflanzenschutz-Nachr. 34, 121-151 (1981); of formulations and potential uses: W. Behrenz et al., ibid. 36, 127-176 (1983). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Deltamethrin CAS Registry Number: 52918-63-5 溴氰菊酯

CAS Name: (1R,3R)-3-(2,2-Dibromoethenyl)-2,2-dimethylcyclopropanecarboxylic acid (S)-cyano(3-phenoxyphenyl)methyl ester
Additional Names: (S)-a-cyano-3-phenoxybenzyl-(1R)-cis-3-(2,2-dibromoviny...
Literature References: Synthetic pyrethroid insecticide. Prepn of racemic mixture: M. Elliot et al., DE 2439177 (1975 to NRDC), C.A. 83, 73519z (1975); of decamethrin and isomers: eidem, Pestic. Sci. 9, 105 (1978). Activity: eidem, Nature 248, 710 (1974); eidem, Pestic. Sci. 9, 112 (1978). Absolute configuration: J. D. Owen, J. Chem. Soc. Perkin Trans. 1 1975, 1865. Photochemistry: L. O. Ruzo et al., J. Agric. Food Chem. 25, 1385 (1977). Metabolism: eidem, ibid. 26, 918 (1978). Toxicology: R. Kavlock et al., J. Environ. Pathol. Toxicol. 2, 751 (1979). Pharmacological effects on central nervous system: P. H. Chanh et al., Arzneim.-Forsch. 34, 175 (1984). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.

Phenothrin CAS Registry Number: 26002-80-2 苯醚菊酯

CAS Name: 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid (3-phenoxyphenyl)methyl ester
Additional Names: 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic acid m-phenoxyb...
Literature References: Synthetic pyrethroid insecticide. Prepn of racemic mixture: N. Itaya et al., DE 1926433 corresp to US 3666789 (1969, 1972 to Sumitomo). Comparative activity of isomers: K. Fujimoto et al., Agric. Biol. Chem. 37, 2681 (1973); Y. Okuno et al., DE 2348930 corresp to US 3934023 (1973, 1976 to Sumitomo). Analysis: Y. Takimoto et al., Anal. Methods Pestic. Plant Growth Regul. 13, 133-146 (1984). Review of toxicology and human exposure: Toxicological Profile for Pyrethrins and Pyrethroids (PB2004-100004, 2003) 332 pp.