其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Fentrazamide CAS Registry Number: 158237-07-1 四唑酰草胺

CAS Name: 4-(2-Chlorophenyl)-N-cyclohexyl-N-ethyl-4,5-dihydro-5-oxo-1H-tetrazole-1-carboxamide
Additional Names: 1-(2-chlorophenyl)-4-(N-cyclohexyl-N-ethylcarbamoyl)-5(4H)-tetrazolinoneTrademar...
Literature References: Tetrazolinone herbicide for use in rice. Prepn: T. Goto et al., EP 612735; eidem, US 5362704 (both 1994 to Nihon Bayer). Mode of action study: C. Fedtke et al., Pestic. Sci. 55, 566 (1999). Field trial in combination with propanil on seeded rice: H. Fürsch, Brighton Crop Prot. Conf. - Weeds 1999, 99. Comprehensive review: Y. Yasui et al., ibid. 1997, 67-72. Series of articles on properties, metabolism, and field trials: Pflanzenschutz-Nachr. Bayer (Engl. Ed.) 54, 5-142 (2001).

Spiromesifen CAS Registry Number: 283594-90-1 螺甲螨酯

CAS Name: 3,3-Dimethyl butanoic acid 2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl ester
Additional Names: 3-(2,4,6-trimethylphenyl)-4-neopentylcarbonyloxy-5,5-tetramethylene-D3-...
Literature References: Tetronic acid acaricide and whitefly insecticide for use in cotton, vegetables and ornamentals. Prepn: R. Fischer et al., EP 528156; eidem, US 5262383 (both 1993 to Bayer); see also: U. Wachendorff-Neumann, US 6436988 (2002 to Bayer). Review of properties and activity: R. Nauen et al., BCPC Conf. - Pests Dis. 2002, 39-44. Series of articles on discovery, properties, ecological profile, and field trials: Pflanzenschutz-Nachr. Bayer 58, 307-502 (2005).

Diflorasone CAS Registry Number: 2557-49-5 二氟拉松

CAS Name: (6a,11b,16b)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 6a,9a-difluoro-16b-methyl-D1,4-pregnadiene-11b,17a,21-triol-3,20-dione; 6a,9a-difl...
Literature References: The 16b-analog of flumethasone, q.v. Prepn of free alcohol and 21-acetate: GB 881334 (1961 to Pfizer), C.A. 56, 15586c (1962); GB 898293; F. H. Lincoln et al., US 3557158 (1962, 1971 both to Upjohn); GB 912015 (1962 to Merck Co.). Prepn of the 17,21-diacetate: D. E. Ayer et al., DE 2308731; eidem, US 3980778 (1973, 1976 both to Upjohn). Proposed mechanism of action: S. Hammarstrom et al., Science 197, 994 (1977). Pharmacology: S. Wickrema et al., J. Invest. Dermatol. 71, 372 (1978). Clinical study: S. M. Bluefarb et al., J. Int. Med. Res. 4, 454 (1976).

Epicholesterol CAS Registry Number: 474-77-1 表胆甾醇

CAS Name: (3a)-Cholest-5-en-3-ol
Percent Composition: C 83.87%, H 11.99%, O 4.14%
Literature References: The 3a-hydroxy epimer of cholesterol. Prepd from 8-oxocholesteryl chloride or from cholest-5-en-3-one or by passing O2 into a soln of cholesteryl Mg chloride: Ruzicka, Goldberg, Helv. Chim. Acta 19, 1407 (1936); Marker, et al., J. Am. Chem. Soc. 58, 481 (1936); Marker, US 2117355 (1938); Barnett et al., J. Chem. Soc. 1940, 1390.

Diflucortolone CAS Registry Number: 2607-06-9 双氟可龙

CAS Name: (6a, 11b, 16a)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 6a,9a-difluoro-16a-methyl-1,4-pregnadiene-11b,21-diol-3,20-dione; 6a,9a-difluoro-16a...
Literature References: The 9a-fluoro deriv of fluocortolone, q.v. Prepn: BE 639708; K. Kieslich et al., US 3426128 (1964, 1969, both to Schering AG); eidem, Arzneim.-Forsch. 26, 1462 (1976). Toxicity: P. Gunzel et al., ibid. 1476. Series of articles on pharmacology, toxicity, metabolism and clinical studies: ibid. 26, 1463-1513 (1976).

Methyleneaminoacetonitrile CAS Registry Number: 109-82-0 亚甲氨基乙腈

Additional Names: a-Hydroformamine cyanide
Percent Composition: C 52.93%, H 5.92%, N 41.15%
Literature References: The actual molecular formula is C9H12N6: Johnson, Rinehart, J. Am. Chem. Soc. 46, 768, 1653 (1924). Prepd by the action of formaldehyde on a mixture of ammonium chloride, potassium cyanide and acetic acid: Adams, Langley, Org. Synth. coll. vol. I (2nd ed., 1941) p 355.

Undecoylium Chloride CAS Registry Number: 1337-59-3

Additional Names: Acylcolaminoformylmethylpyridinium chloride
Literature References: The acyl group is a mixture containing 8-14 carbon atoms, but principally a 10-11 carbon atom chain. [C5H5N+-CONHCH2CH2OOC(CH2)nCH3]Cl-, where n = 6-12.

Apigenin CAS Registry Number: 520-36-5 芹菜素; 芹黄素; 5,7,4'-三羟基黄酮

CAS Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 4',5,7-trihydroxyflavone; 2-(p-hydroxyphenyl)-5,7-dihydroxychromone; pelargidenon 1449
Percent Composition...
Literature References: The aglucon of apiin and of apigenin-7-glucoside. From apiin by boiling with acids, from apigenin-7-glucoside by enzymatic hydrolysis with emulsin or by boiling with 15% H2SO4. Isoln and structure: Czajkowski et al., Ber. 33, 1992 (1900); Schmid, Waschkau, Monatsh. Chem. 49, 83 (1928); Baker et al., J. Chem. Soc. 1963, 1477. Synthesis: Hutchins, Wheeler, ibid. 1939, 91; Farooq et al., Arch. Pharm. 292, 792 (1959).

Baptigenin CAS Registry Number: 5908-63-4

CAS Name: 7-Hydroxy-3-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 7,3',4',5'-tetrahydroxyisoflavone
Percent Composition: C 62.94%, H 3.52%, O 33.54%
Literature References: The aglucon of baptisin. From baptisin by acid hydrolysis or vacuum sublimation. From radix Baptisiae: Fischer, Ehrlich, C.A. 31, 44493 (1937). Structure: Böhm, Arzneim.-Forsch. 10, 472 (1960). Synthesis: Farkas et al., Ber. 96, 1865 (1963). See also Pseudobaptigenin.

Daidzein CAS Registry Number: 486-66-8 大豆苷元

CAS Name: 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 4',7-dihydroxyisoflavone
Percent Composition: C 70.86%, H 3.96%, O 25.17%
Literature References: The aglucon of daidzin, prepd by hydrolysis with HCl in methanol: Walz, Ann. 489, 118 (1931). Isoln from red clover: Wong, J. Sci. Food Agric. 13, 304 (1962); from the mold Micromonospora halophytica: Ganguly, Sarre, Chem. Ind. (London) 1970, 201. Synthesis: Baker et al., J. Chem. Soc. 1933, 274; Wessely et al., Ber. 66, 685 (1933); Mahal et al., J. Chem. Soc. 1934, 1769; Baker et al., ibid. 1953, 1852; Farkas, Ber. 90, 2940 (1957). Biosynthetic study: Grisebach, Zilg, Z. Naturforsch. 23b, 494 (1968).