其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Hygrophylline CAS Registry Number: 3573-82-8 阔叶千里光裂碱环5-亚乙基-2,4-二羟基-2,3-二甲基己二酸酯(酯)

CAS Name: (1a,14a)-1,2-Dihydro-12,14-dihydroxysenecionan-11,16-dione
Percent Composition: C 61.17%, H 7.70%, N 3.96%, O 27.16%
Literature References: Pyrrolizidine alkaloid isolated from Senecio hygrophyllus Dyer and Sm., Compositae: Richardson, Warren, J. Chem. Soc. 1943, 452. Structure and stereochemistry: Schlosser, Warren, ibid. 1965, 5707. NMR spectrum: S. E. Drewes et al., J. Chem. Soc. Perkin Trans. 1 1981, 287. X-ray crystallography: M. F. Mackay et al., Acta Crystallogr. C41, 395 (1985).

Homarine CAS Registry Number: 445-30-7 N-甲-2-吡啶甲酸

CAS Name: 2-Carboxy-1-methylpyridinium inner salt
Additional Names: 1-methyl-2-pyridinium carboxylate; picolinic acid N-methylbetaine; N-methylpicolinic acid
Percent Composition: C 61.31%, H...
Literature References: Quaternary ammonium base occurring in tissues of marine animals such as sea urchin, Arabacia pustulosa, jellyfish, Velella spirans, lugworm, Arenicola marina. Isoln: Hoppe-Seyler, Z. Physiol. Chem. 222, 105 (1933). Prepn: Kosower, Patton, J. Org. Chem. 26, 1318 (1961); Quast, Schmitt, Ann. 732, 64 (1970). Review of distribution and function in animals: Brodzicki, Kosmos (Warsaw) 16A, 431- 438 (1967), C.A. 68, 18617v (1968).

Tiquizium Bromide CAS Registry Number: 71731-58-3 替喹溴铵

CAS Name: (5R,9aR)-rel-3-(Di-2-thienylmethylene)octahydro-5-methyl-2H-quinolizinium bromide
Additional Names: 3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromideTrademarks: Thiaton...
Literature References: Quaternary ammonium salt with anticholinergic activity. Prepn: H. Kato et al., BE 866988 (1978 to Hokuriku), C.A. 90, 151996p (1979); H. Kato, E. Koshinaka, US 4205074 (1980 to Hokuriku). Synthesis and anticholinergic activity: E. Koshinaka et al., Chem. Pharm. Bull. 27, 1454 (1979). Pharmacological comparison with other antispasmodics: S. Kubo et al., Jpn. J. Pharmacol. 30, 103P (1980). Pharmacology: M. Yamazaki et al., Oyo Yakuri 23, 417, 423 (1981), C.A. 97, 66016u, 66017v (1982). HPLC determn in biological fluids: T. Yamada et al., Yakugaku Zasshi 103, 1319 (1983), C.A. 100, 131957y (1984).

Benzethonium Chloride CAS Registry Number: 121-54-0 苄索氯铵

CAS Name: N,N-Dimethyl-N-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]benzenemethanaminium chloride
Additional Names: benzyldimethyl[2-[2-(p-1,1,3,3-tetramethylbutylphenoxy)ethoxy]et...
Literature References: Quaternary ammonium salt with antimicrobial activity. Prepn: H. A. Bruson, US 2115250 (1938 to Rohm Haas). Germicidal activity and toxicity data: P. Weiss et al., J. Am. Pharm. Assoc. Sci. Ed. 40, 267 (1951). HPLC determn in fish: T. B. A. Reuvers et al., J. Chromatogr. 467, 321 (1989). Use for determn of total protein in cerebrospinal fluid (CSF): R. W. Luxton et al., Clin. Chem. 35, 1731 (1989). Review of properties, commercial uses and toxicology studies: J. Am. Coll. Toxicol. 4, 65-106 (1985).

Otilonium Bromide CAS Registry Number: 26095-59-0 奥替溴铵

CAS Name: N,N-Diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]ethanaminium bromide
Additional Names: octylonium bromideTrademarks: Doralin (Menarini); Menoctyl (Dong Wha); Pasmin...
Literature References: Quaternary ammonium salt with gastrointestinal spasmolytic activity. Prepn: BE 704269; M. Ghelardoni et al., US 3536723 (1968, 1970 both to Menarini); idem et al., J. Med. Chem. 16, 1063 (1973). Determn of finished pharmaceutical forms by HPLC: C. Mannucci et al., J. Pharm. Sci. 82, 367 (1993); by CE: S. Furlanetto et al., Analyst 126, 1700 (2001). Receptor binding study: S. Lindqvust et al., Br. J. Pharmacol. 137, 1134 (2002). Clinical trial in irritable bowel syndrome: G. Battaglia et al., Aliment. Pharmacol. Ther. 12, 1003 (1998). Review of pharmacology and clinical efficacy: S. Evangelista, J. Int. Med. Res. 27, 207-222 (1999); comparative review of clinical studies: idem, Curr. Pharm. Des. 10, 3561-3568 (2004).

Cinchophen CAS Registry Number: 132-60-5 2-苯基-4-喹啉羧酸

CAS Name: 2-Phenyl-4-quinolinecarboxylic acid
Additional Names: 2-phenylcinchoninic acid
Trademarks: Atophan (Warner-Chilcott); Quinophan; Phenoquin; Agotan; Artam; Alutyl; Cinconal; Vantyl;...
Literature References: Quinoline derivative formerly used in treatment of chronic gout: A. B. Gutman, Arthritis Rheum. 16, 431 (1973). Prepd by heating pyruvic acid with aniline and benzaldehyde or with benzylidene aniline in abs alcohol: Doebner, Gieseke, Ann. 242, 290 (1887). Also from acetophenone and isatinic acid in alcoholic KOH: Pfitzinger, J. Prakt. Chem. 38, 582 (1882); 56, 293 (1897). Cinchophen as ulcerogenic agent: T. P. Churchill, F. H. van Wagoner, Arch. Pathol. 13, 850 (1932); N. Umeda et al., Toxicol. Appl. Pharmacol. 18, 102 (1971); T. H. Stewart et al., J. Pathol. 131, 363 (1980). Mitochondrial toxicity of cinchophen and derivatives: H. Vainio et al., Biochem. Pharmacol. 20, 1589 (1971).

Quinoxyfen CAS Registry Number: 124495-18-7 苯氧喹啉

CAS Name: 5,7-Dichloro-4-(4-fluorophenoxy)quinolineTrademarks: Fortress (Dow AgroSci.); Quintec (Dow AgroSci.)
Percent Composition: C 58.47%, H 2.62%, Cl 23.01%, F 6.17%, N 4.55%, O 5.19%
Literature References: Quinoline fungicide for powdery mildew control in cereals, grapes and hops; inhibits formation of appressoria through which the fungus invades the plant. Prepn: W. R. Arnold et al., EP 326330 (1989 to Eli Lilly); eidem, US 5145843 (1992 to DowElanco). Properties and field trials: C. Longhurst et al., Brighton Crop Prot. Conf. - Pests Dis. 1996, 27. Resistance profile: D. W. Hollomon et al., ibid. 701. Metabolism and environmental fate: G. L. Reeves et al., ibid. 1169. Determn and fate in grapes, raisins and wine: P. Cabras et al., J. Agric. Food Chem. 48, 6128 (2000).

Rosoxacin CAS Registry Number: 40034-42-2 1-乙基-4-氧代-7-(4-吡啶基)-1,4-二氢喹啉-3-甲酸

CAS Name: 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid
Additional Names: acrosoxacinTrademarks: Eracine (Sanofi Winthrop); Eradacil (Winthrop); Eradacin (Sanofi Winthrop...
Literature References: Quinolone antibacterial. Prepn: G. Y. Lesher, P. M. Carabateas, DE 2224090; eidem, US 3753993 (1972, 1973 both to Sterling). HPLC determn in plasma and urine: M. P. Kullberg et al., J. Chromatogr. 173, 155 (1979). Pharmacological studies: S. Maigaard et al., Urol. Res. 8, 113 (1980); eidem, Invest. Urol. 17, 149 (1979). Clinical study in gonorrhea: B. M. Limson et al., Curr. Ther. Res. 26, 842 (1979).

Piromidic Acid CAS Registry Number: 19562-30-2 吡乙酸三氮萘

CAS Name: 8-Ethyl-5,8-dihydro-5-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acid
Additional Names: 5,8-dihydro-8-ethyl-5-oxo-2-pyrrolidinopyrido[2,3-d]pyrimidine-6-carboxylic aci...
Literature References: Quinolone antibacterial. Prepn: S. Minami et al., JP 67 25912; eidem, GB 1129358 (1967, 1968 both to Dainippon Pharm.); eidem, Chem. Pharm. Bull. 19, 1426 (1971). Activity studies: M. Shimizu et al., Antimicrob. Agents Chemother. 1970, 117. Metabolism: eidem, ibid. 123.

Miloxacin CAS Registry Number: 37065-29-5 米洛沙星

CAS Name: 5,8-Dihydro-5-methoxy-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
Additional Names: 6,7-methylenedioxy-1-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; antibiotic AB 20...
Literature References: Quinolone antibacterial; analog of oxolinic acid, q.v. Prepn: T. Nakagome et al., DE 2134451; eidem, US 3799930 (1972, 1974 both to Sumitomo). Mode of action: T. Nagate et al., Antimicrob. Agents Chemother. 17, 763 (1980). Series of articles on antibacterial activity, absorption and excretion in animals, determn of metabolites by HPLC: ibid. 18, 37-49 (1980). Reproduction studies in rats: T. Yamada et al., Oyo Yakuri 19, 651, 815, 833 (1980), C.A. 93, 197897x, 215570s, 215571t (1980).