其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cinoxacin CAS Registry Number: 28657-80-9 西诺沙星

CAS Name: 1-Ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
Additional Names: 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acidTrademarks: Cinobac (Lilly); N...
Literature References: Quinolone antibacterial; analog of oxolinic acid, q.v. Prepn: W. A. White, DE 2005104; idem, US 3669965 (1970, 1972 both to Lilly). In vitro and in vivo study: W. E. Wick et al., Antimicrob. Agents Chemother. 4, 415 (1973). Pharmacology: J. J. Szwed et al., J. Antimicrob. Chemother. 4, 451 (1978); K. S. Israel et al., J. Clin. Pharmacol. 18, 491 (1978). Metabolism: R. L. Wolen et al. in Stable Isotopes, T. A. Baillie, Ed. (Univ. Park Press, Baltimore, 1978) pp 113-125. Clinical studies: S. Colleen et al., J. Antimicrob. Chemother. 3, 579 (1977); S. N. Rous, J. Urol. 120, 196 (1978). Toxicity: I. Narama et al., Chemotherapy (Tokyo) 28, Suppl. 4, 406 (1980), C.A. 94, 25007 (1981). Pharmacokinetics: M. Ohkawa et al., J. Antimicrob. Chemother. 8, 447 (1981); R. Barbhaiya et al., Antimicrob. Agents Chemother. 21, 472 (1982). Review: J. M. Scavone et al., Pharmacotherapy 2, 266-271 (1982). Review of pharmacology and therapeutic efficacy: T. S. Sisca et al., Drugs 25, 544-569 (1983).

Tris(trimethylsilyl)silane CAS Registry Number: 1873-77-4 三(三甲硅基)硅烷

CAS Name: 1,1,1,3,3,3-Hexamethyl-2-(trimethylsilyl)trisilane
Percent Composition: C 43.47%, H 11.35%, Si 45.18%
Literature References: Radical based mediator. Prepn: H. Gilman et al., Chem. Ind. (London) 1965, 848; H. Bürger, W. Kilian, J. Organomet. Chem. 18, 299 (1969). Si-H bond dissociation energies: J. M. Kanabus-Kaminska et al., J. Am. Chem. Soc. 109, 5268 (1987). Identification as reducing agent: C. Chatgilialoglu et al., J. Org. Chem. 53, 3641 (1988). Use as a reducing agent: M. Ballestri et al., ibid. 56, 678 (1991); D. H. R. Barton et al., Tetrahedron Lett. 33, 6629 (1992); in carbonylation: I. Ryu et al., Synlett 1993, 143.

Phosphocysteamine CAS Registry Number: 5746-40-7 半胱胺-S-磷酸酯

CAS Name: 2-Aminoethanethiol dihydrogen phosphate (ester)
Additional Names: phosphorothioic acid S-(2-aminoethyl) ester; cysteamine-S-phosphate; MEAP
Percent Composition: C 15.29%, H 5.13%, ...
Literature References: Radioprotectant. Prepn of sodium salt: S. Åkerfeldt, Acta Chem. Scand. 13, 1479 (1959); of free acid: idem, ibid. 14, 1980 (1960). Radioprotective effect: B. Hansen, B. Sörbo, Acta Radiol. 56, 141 (1961); A. Vacek et al., Folia Biol. (Prague) 17, 340 (1971). Mechanism of action: B. Shapiro et al., Radiat. Res. 44, 421 (1970). Radiobiological and biochemical profile: J. W. Harris, T. L. Phillips, ibid. 46, 362 (1971). Photoreactivity: S. A. Grachev et al., Radiochem. Radioanal. Lett. 19, 283 (1974); H. Neumann, M. Sokolovsky, Biochim. Biophys. Acta 381, 292 (1975). Clinical evaluation in cystinosis: L. A. Smolin et al., Pediatr. Res. 23, 616 (1988); D. S. Theodoropoulos et al., J. Am. Med. Assoc. 270, 2200 (1993).

Polydextrose CAS Registry Number: 68424-04-4 聚葡萄糖

Trademarks: Litesse (Pfizer)
Literature References: Randomly bonded condensation polymer of dextrose with small amounts of bound sorbitol and citric acid. Functions to replace the bulk and mouthfeel of sugar and/or fat in reduced calorie foods. Prepn: H. H. Rennhard, US 3766165 (1973 to Pfizer). Improved process: D. B. Guzek et al., EP 473333 (1992 to Pfizer); C.A. 116, 237725s (1992). Reviews of physical properties and applications in foods: A. Torres, R. D. Thomas, Food Technol. 35, 44-49 (1981); F. K. Moppett in Food Sci. Technol. 48, entitled "Alternative Sweeteners", L. O. Nabors, R. C. Gelardi, Eds. (1991) pp 401-421.

Phenacetolin CAS Registry Number: 1340-26-7

Additional Names: Degener's indicator
Literature References: Reaction product of concd H2SO4 and glacial acetic acid on phenol.

Methyl Cyanoacrylate CAS Registry Number: 137-05-3 2-氰基丙烯酸甲酯

CAS Name: 2-Cyano-2-propenoic acid methyl ester
Additional Names: 2-cyanoacrylic acid methyl ester; MCA; mecrilate; mecrylate; methyl 2-cyanoacrylate; methyl a-cyanoacrylate
Percent Composit...
Literature References: Reacts rapidly with water to form solid polymers. Preparative methods: A. E. Ardis, US 2467927 (1949 to B. F. Goodrich); C. H. McKeever, US 2912454 (1959 to Rohm Haas). Prepn, polymerization and degradation: F. Leonard et al., J. Appl. Polym. Sci. 10, 259 (1966). Clinical evaluation for tubal occlusion in female sterilization: Contraception 31, 243 (1985). Review of chemistry and toxicology: R. Cary, Concise Int. Chem. Assess. Doc. No. 36 (WHO, Geneva, 2001) 33 pp.

Ellman's Reagent CAS Registry Number: 69-78-3 5,5＇二硫代双(2-硝基苯甲酸)(DTNB)

CAS Name: 3,3'-Dithiobis[6-nitrobenzoic acid]
Additional Names: 5,5'-dithiobis[2-nitrobenzoic acid]; DTNB
Percent Composition: C 42.42%, H 2.03%, N 7.07%, O 32.29%, S 16.18%
Literature References: Reacts with thiols to produce the yellow dianion of 5-thio-2-nitrobenzoic acid (TNB). Prepn: G. L. Ellman, Arch. Biochem. Biophys. 82, 70 (1959); and spectral properties: P. W. Riddles et al., Anal. Biochem. 94, 75 (1979). Structure determn: E. Shefter, T. I. Kalman, J. Chem. Soc. Chem. Commun. 1969, 1027. Reaction stoichiometry with protein disulfide groups: R. J. Ackerman, J. F. Robyt, Anal. Biochem. 50, 656 (1972). Use in HPLC determn of alkylthiols: K. Kuwata et al., Anal. Chem. 54, 1082 (1982). Molar absorption coefficients for TNB: P. Eyer et al., Anal. Biochem. 312, 224 (2003).

Sulfanilic Acid CAS Registry Number: 121-57-3 对氨基苯磺酸

CAS Name: 4-Aminobenzenesulfonic acid
Additional Names: p-anilinesulfonic acid
Percent Composition: C 41.61%, H 4.07%, N 8.09%, O 27.71%, S 18.51%
Literature References: Readily prepd from aniline and sulfuric acid: I. G. Farben, FIAT Final Rept. 1313 (I), 255 (1948); Fierz-David, Blangey, Fundamental Processes of Dye Chemistry (Interscience, New York, 1949) pp 126-128; A. I. Vogel, Practical Organic Chemistry (Longmans, London, 3rd ed., 1959) p 586; R. Q. Brewster et al., Unitized Experiments in Organic Chemistry (Van Nostrand, Princeton, 2nd ed., 1964) pp 162-163. Improved procedure: Jacobs et al., Ind. Eng. Chem. 35, 321-323 (1943).

Methyl p-Nitrobenzenesulfonate CAS Registry Number: 6214-20-6 对硝基苯磺酸甲酯

CAS Name: p-Nitrobenzenesulfonic acid methyl ester
Percent Composition: C 38.71%, H 3.25%, N 6.45%, O 36.83%, S 14.76%
Literature References: Reagent for selective methylation of cysteine residues in chemical modification of proteins: Nakagawa, Bender, J. Am. Chem. Soc. 91, 1566 (1969). Procedure: Heinrikson, Biochem. Biophys. Res. Commun. 41, 967 (1970). Prepd by the general method of reacting p-nitrobenzenesulfonyl chloride with alcohols. See Morgan, Cretcher, J. Am. Chem. Soc. 70, 375 (1948).

Ishikawa Reagent CAS Registry Number: 309-88-6 N,N-二乙基-1,1,2,3,3,3-六氟丙胺

CAS Name: N,N-Diethyl-1,1,2,3,3,3-hexafluoro-1-propanamine
Additional Names: PPDA
Percent Composition: C 37.67%, H 4.97%, F 51.08%, N 6.28%
Literature References: Reagent for the fluorination of alcohols and esters; prepd from perfluoropropene and diethylamine. Prepn: I. L. Knunyants et al., Bull. Acad. Sci. USSR Div. Chem. Sci. 1953, 255; D. C. England et al., J. Am. Chem. Soc. 82, 5116 (1960); A. Y. Yakubovich et al., Dokl. Akad. Nauk SSSR (Engl. Transl.) 161, 399 (1965); and use as a fluorinating agent: A. Takaoka et al., Bull. Chem. Soc. Jpn. 52, 3377 (1979). Synthetic applications: S. Watanabe et al., J. Fluorine Chem. 31, 135, 247 (1986); 36, 361 (1987); 38, 243 (1988); 39, 17 (1988); 47, 187 (1990); K. Ogu et al., Tetrahedron Lett. 39, 305 (1998); G. Koch et al., Synlett 2004, 693.