其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Trifluoromethyltrimethylsilane CAS Registry Number: 81290-20-2 (三氟甲基)三甲基硅烷

CAS Name: Trimethyl(trifluoromethyl)silane
Additional Names: Ruppert's reagent; TMS-CF3
Percent Composition: C 33.79%, H 6.38%, F 40.08%, Si 19.75%
Literature References: Reagent used for fluoride ion catalyzed trifluoromethylation of organic substrates. Prepn: I. Ruppert et al., Tetrahedron Lett. 25, 2195 (1984); and use in trifluoromethylation of aldehydes and ketones: G. K. S. Prakash et al., J. Am. Chem. Soc. 111, 393 (1989). Review of chemistry: G. K. S. Prakash, A. K. Yudin, Chem. Rev. 97, 757-786 (1997); R. P. Singh, J. M. Shreeve, Tetrahedron 56, 7613-7632 (2000).

Gibbs Reagent CAS Registry Number: 101-38-2 2,6-二氯醌-4-氯亚胺

CAS Name: 2,6-Dichloro-4-(chloroimino)-2,5-cyclohexadien-1-one
Additional Names: 2,6-dichloro-p-benzoquinone-4-chloroimine; N,2,6-trichloro-p-quinoneimine; 2,6-dichloroquinone chloroimide; N,2,...
Literature References: Reagent used to determine the presence of phenols. The reaction with phenols unsubstituted in the para position is called the Gibbs Reaction: H. D. Gibbs, Chem. Rev. 3, 291 (1927). Prepn of the reagent: idem, J. Biol. Chem. 72, 649 (1927); G. I. Mikhailov, Trans. Inst. Pure Chem. Reagents 16, 83 (1939). Analysis of the Gibbs color reaction: J. C. Dacre, Anal. Chem. 43, 589 (1971).

Astacin CAS Registry Number: 514-76-1 beta,beta-胡罗卜素-3,3',4,4'-四酮

CAS Name: b,b-Carotene-3,3',4,4'-tetrone
Additional Names: 3,4,3',4'-tetraketo-b-carotene; 3,3'-dihydroxy-2,3,2',3'-tetradehydro-b,b-carotene-4,4'-dione; astacene
Percent Composition: C 81.0...
Literature References: Red carotenoid pigment isolated from biological material originating from crustacea, algae, sponges, protozoa, fish and reptiles. Small amounts were isolated from the fat of mammals (whales, Balaenoptera musculus). Occurs together with astaxanthin from which it is formed by autoxidation. Appears to be an artifact rather than a natural product. Isoln from lobster shells: Kuhn, Lederer, Ber. 66, 488 (1933). Structure: Karrer et al., Helv. Chim. Acta 17, 412, 745 (1934); 18, 96 (1935); 19, 479 (1936). Total synthesis: J. B. Davis, B. C. L. Weedon, Proc. Chem. Soc. London 1960, 182; E. Widmer et al., Helv. Chim. Acta 65, 671 (1982). Prepn by autoxidation of canthaxanthin: R. D. G. Cooper et al., J. Chem. Soc. Perkin Trans. 1 1975, 2195.

Herqueinone CAS Registry Number: 26871-30-7 3H-Phenaleno[1,2-b]呋喃-3,7(7aH)-二酮,8,9-二氢-4,6,7a-三羟基-5-甲氧基-1,8,8,9-四甲基,(7aS,9R)-

CAS Name: (7aS,9R)-8,9-Dihydro-4,6,7a-trihydroxy-5-methoxy-1,8,8,9-tetramethyl-3H-phenaleno[1,2-b]furan-3,7(7aH)-dione
Percent Composition: C 64.51%, H 5.41%, O 30.08%
Literature References: Red fungal pigment isolated from Penicillium herquei: Stodola et al., Nature 167, 773 (1951); Galarraga et al., Biochem. J. 61, 456 (1955); Harman et al., J. Org. Chem. 20, 1260 (1955). Structure: Cason et al., Tetrahedron 18, 839 (1962); Paul, Sim, Proc. Chem. Soc. London 1962, 352; Cason et al., J. Org. Chem. 35, 179 (1970); J. S. Brooks, G. A. Morrison, Tetrahedron Lett. 1970, 963; eidem, J. Chem. Soc. Perkin Trans. 1 1972, 421; 1974, 2114. Crystal structure and abs config: A. Quick et al., Chem. Commun. 1980, 1051. 13C-NMR study: T. Suga et al., Chem. Lett. 1981 1063.

Bis(2-mercaptoethyl)sulfone CAS Registry Number: 145626-87-5 2,2'-磺酰基二乙硫醇

CAS Name: 2,2'-Sulfonylbis(ethanethiol)
Additional Names: BMS
Percent Composition: C 25.79%, H 5.41%, O 17.17%, S 51.63%
Literature References: Reducing agent for proteins. Prepn: G. V. Lamoureux, G. M. Whitesides, J. Org. Chem. 58, 633 (1993). Enhanced reduction rate in comparison with dithiothreitol, q.v.: R. Singh, G. M. Whitesides, Bioorg. Chem. 22, 109 (1994). Use in reduction of disulfide bonds: D. Winitz et al., J. Biol. Chem. 271, 27645 (1996); A. Brunella, O. Ghisalba, J. Mol. Catal. B 10, 215 (2000); S. Lee, J. P. N. Rosazza, Org. Lett. 6, 365 (2004).

Sodium Cyanoborohydride CAS Registry Number: 25895-60-7 氰基硼氢钠

CAS Name: Sodium (cyano-C)trihydroborate(1-)
Additional Names: sodium borocyanohydride; sodium cyanohydridoborate
Percent Composition: C 19.11%, H 4.81%, B 17.20%, N 22.29%, Na 36.58%
Literature References: Reducing agent prepared from NaBH4 and HCN: R. C. Wade et al., Inorg. Chem. 9, 2146 (1970); R. C. Wade, DE 2028569 corresp to US 3667923 (1971, 1972 both to Ventron). Review of prepn, properties and use: C. F. Lane, Synthesis 1975, 135-146.

Isomaltulose CAS Registry Number: 13718-94-0; 58024-13-8 (monohydrate) 异麦芽酮糖

CAS Name: 6-O-a-D-Glucopyranosyl-D-fructose
Additional Names: 6-O-a-D-glucopyranosyl-D-fructofuranose
Trademarks: Palatinose (Sádeutsche Zucker-Aktiengesellschaft; Shin Mitsui Sugar Co.)
...
Literature References: Reducing disaccharide occurring naturally in honey and sugar cane juice; commercially available in crystalline (42% of the sweetness of sucrose) and molasses (70% of the sweetness of sucrose) forms. Prepn: D. Weidenhagen, S. Lorenz, DE 1049800 (1959 to Süddeutsche Zucker-Aktiengesellschaft); eidem, Z. Zuckerind. 7, 533 (1957); E. S. Sharpe et al., J. Org. Chem. 25, 1062 (1960). Clinical effects on glucose levels in diabetic patients: K. Kawai et al., Horm. Metab. Res. 21, 338 (1989). Review of cariological studies: D. Birkhed et al., Dtsch. Zahnaerztl. Z. 42, S124-S127 (1987). Review of development and properties: W. E. Irwin, P. J. Sträter in Alternative Sweeteners, L. O'Brien Nabors, R. C. Gelardi, Eds. (Marcel Dekker, Inc., New York, 1991) pp 299-307; and production and clinical activity: I. Takazoe in Progress in Sweeteners, T. H. Grenby, Ed. (Elsevier, Barking, UK, 1989) pp 143-167. Review of toxicology and metabolism: B. A. R. Lina et al., Food Chem. Toxicol. 40, 1375-1381 (2002).

Deoxydihydrostreptomycin CAS Registry Number: 26086-49-7 4-O-[2-O-[2-(甲基氨基)-2-脱氧-alpha-L-吡喃葡萄糖基]-3,5-二脱氧-3-羟基甲基-alpha-L-阿拉伯呋喃糖基]-N,N'-二(氨基亚胺甲基)-D-链霉胺

CAS Name: O-2-Deoxy-2-(methylamino)-a-L-glucopyranosyl-(1®2)-O-3,5-dideoxy-3-(hydroxymethyl)-a-L-arabinofuranosyl-(1®4)-N,N'-bis(aminoiminomethyl)-D-streptamine
Additional Names: dihydrodeoxyst...
Literature References: Reduction product of streptomycin. Prepn and structure: Ikeda, C.A. 50, 13765g (1956); Yabuta et al., US 2837510 (1958); Gailliot, Baget, FR 1198042 (1959 to Rhône-Poulenc). TLC separation: H. Heding, Acta Chem. Scand. 24, 3086 (1970). Comparative antibacterial activity of streptomycin analogs: H. Heding, O. Lützen, J. Antibiot. 25, 287 (1972).

Carbutamide CAS Registry Number: 339-43-5 氨磺丁脲

CAS Name: 4-Amino-N-[(butylamino)carbonyl]benzenesulfonamide
Additional Names: 1-butyl-3-sulfanilylurea; N1-(butylcarbamoyl)sulfanilamide; N1-sulfanilyl-N2-butylurea; N1-sulfanilyl-N2-butylcarb...
Literature References: Ref: Achelis, Hardebeck, Dtsch. Med. Wochenschr. 80, 1452 (1955); Achelis et al., Arch. Exp. Pathol. Pharmakol. 228, 163 (1956). Prepn from butylurea and sulfanilamide: Samaniego, ES 229696 (1956), C.A. 51, 7413 (1957); E. Haack, A. Hagedorn, US 2907692 (1959 to Boehringer, Mann.).

Oxophenarsine Hydrochloride CAS Registry Number: 538-03-4 2-胺-4-氧亚砷苯酚盐酸盐

CAS Name: 2-Amino-4-arsenosophenol hydrochloride
Additional Names: 3-amino-4-hydroxyphenyl arsinoxide hydrochlorideTrademarks: Arsenoxide; Mapharsen (Parke-Davis); Mapharside; Mapharsal; Fontar...
Literature References: Ref: G. W. Raiziss, J. L. Gavron, Organic Arsenical Compounds (Chem. Catalog Co., New York, 1923), pp 136-137; Scott, Tullar, CA 405532 (1942 to Parke, Davis).