其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Chartreusin CAS Registry Number: 6377-18-0 莱姆勃霉素

CAS Name: 10-[[6-Deoxy-2-O-(6-deoxy-3-O-methyl-a-D-galactopyranosyl)-b-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione
Additional Names: anti...
Literature References: Antibiotic substance produced by Streptomyces chartreusis from African soil, also by another Streptomyces sp. from North American soil: B. E. Leach et al., J. Am. Chem. Soc. 75, 4011 (1953). Identity with Antibiotic X-465A: J. Berger et al., ibid. 80, 1636 (1958). Structure: L. H. Sternbach et al., ibid. 1639; E. Simonitsch et al., Helv. Chim. Acta 47, 1459 (1964); W. Eisenhuth et al., ibid. 1475. Anticancer activity: J. P. McGovern et al., Cancer Res. 37, 1666 (1977). Synthesis of chartarin, the chartreusin aglycone: T. R. Kelly et al., J. Am. Chem. Soc. 102, 798 (1980); F. M. Hauser, D.W. Combs, J. Org. Chem. 45, 4071 (1980).

Collinomycin CAS Registry Number: 27267-69-2 alpha-玉红霉素

CAS Name: 6-[2-(4,9-Dihydro-8-hydroxy-5,7-dimethoxy-4,9-dioxonaphtho[2,3-b]furan-2-yl)ethyl]-7,8-dihydroxy-1-oxo-1H-2-benzopyran-3-carboxylic acid methyl ester
Additional Names: a-rubromycin Literature References: Antibiotic substance produced by Streptomyces collinus: Brockmann, Renneberg, Naturwissenschaften 40, 166 (1953); DE 918162 (1954 to Bayer). Identity with a-rubromycin: Brockmann et al., Tetrahedron Lett. 1966, 3525. Structure: Brockmann, Zeeck, Ber. 103, 1709 (1970). Shows considerable in vitro-activity against Staph. aureus.

Amidinomycin CAS Registry Number: 3572-60-9 环戊烷e羧酰胺,3-氨基-N-(3-氨基-3-亚氨基丙基)-,(1R,3S)-

CAS Name: 3-Amino-N-(3-amino-3-iminopropyl)cyclopentanecarboxamide
Additional Names: N-(2'-amidinoethyl)-3-aminocyclopentanecarboxamide; myxoviromycin
Percent Composition: C 54.52%, H 9.15%,...
Literature References: Antibiotic substance produced by Streptomyces flavochromogenes isolated from Japanese soil (Shiuoka Prefecture). Isoln and structure: S. Nakamura et al., J. Antibiot. 14A, 103 (1961); S. Nakamura, Chem. Pharm. Bull. 9, 641 (1961). Identity with myxoviromycin: S. Nakamura et al., J. Antibiot. 14A, 163 (1961). Prepn: Katsube, Saito, JP 68 21418 (1968 to Sumitomo), C.A. 70, 87135q (1969). Synthesis of amidinomycin and trans isomer: H. Paul et al., Arch. Pharm. 301, 512 (1968). Crystal and molecular structure: M. Kaneda et al., J. Antibiot. 33, 778 (1980).

Cycloserine CAS Registry Number: 68-41-7 D-环丝氨酸

CAS Name: D-4-Amino-3-isoxazolidinone
Additional Names: D-4-amino-3-isoxazolidone; orientomycinTrademarks: Closina; Farmiserina (Farmitalia); Micoserina; Oxamycin (Merck Co.); Seromycin (Lilly...
Literature References: Antibiotic substance produced by Streptomyces garyphalus sive orchidaceus: Kuehl, Jr., et al., J. Am. Chem. Soc. 77, 2344 (1955); Hidy et al., ibid. 2345; Shull, Sardinas, Antibiot. Chemother. 5, 398 (1955); Shull et al., US 2773878 (1956 to Pfizer); Harned, US 2789983 (1957 to Commercial Solvents); GB 768007 (1957 to Commercial Solvents), C.A. 51, 10847e (1957); US 3124590 (1964 to Commercial Solvents); Howe, US 2845433 (1958 to Merck Co.). Synthesis: Stammer et al., J. Am. Chem. Soc. 77, 2346 (1955); Peck, US 2772280 (1956 to Merck Co.); Plattner et al., Helv. Chim. Acta 40, 1531 (1957); Holly, Stammer, US 2840565 (1958 to Merck Co.). Prepn of crystalline calcium and magnesium salts: Harris et al., US 2832788 (1958 to Merck Co.). HPLC determn in plasma and urine: D. G. Musson et al., J. Chromatogr. 414, 121 (1987). Comprehensive description: J. W. Lamb, Anal. Profiles Drug Subs. 1, 53-64 (1972); H. A. El-Obeid, A. A. Al-Badr, ibid. 18, 567-597 (1989).

Hygromycin CAS Registry Number: 6379-56-2

CAS Name: (E)-5-Deoxy-5-[[3-[4-[(6-deoxy-b-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propenyl]amino]-1,2-O-methylene-D-neo-inositol
Additional Names: homomycin; h...
Literature References: Antibiotic substance produced by Streptomyces hygroscopicus (Jensen) Waksman Henrici, from forest soil near Indianapolis, Ind: R. L. Mann et al., Antibiot. Chemother. 3, 1279 (1953). Produced also by Streptomyces noboritoensis from soil collected in Kanawaga Prefecture. Identity of homomycin and hygromycin: K. Isono et al., J. Antibiot. 10A, 21 (1957). Structure: eidem, ibid. 160; R. L. Mann, D. O. Woolf, J. Am. Chem. Soc. 79, 120 (1957). Abs config: K. Kakinuma, Y. Sakagami, Agric. Biol. Chem. 42, 279 (1978). Synthesis of the sugar component: M. Nakajima, S. Takahashi, ibid. 31, 1082 (1967). Total synthesis: N. Chida et al., Chem. Commun. 1989, 436. Peptide synthesis inhibitor: M. Guerrero, J. Modolell, Eur. J. Biochem. 107, 409 (1980).

Mycobacidin CAS Registry Number: 539-35-5 杀枝杆菌素

CAS Name: 4-Oxo-2-thiazolidinehexanoic acid
Additional Names: e-[2-(4-thiazolidone)]hexanoic acid; 4-thiazolidone-2-caproic acid; 2-(5-carboxypentyl)-4-thiazolidone; cinnamonin; actithiazic aci...
Literature References: Antibiotic substance produced by Streptomyces lavendulae, Streptomyces virginiae and several other Streptomyces spp. Isoln: Tejera et al., Antibiot. Chemother. 2, 333 (1952). Production by fermentation: Grundy et al., US 2678929 (1954 to Abbott). Synthesis: McLamore et al., J. Am. Chem. Soc. 75, 105 (1953); Nienburg, Friedrichsen, DE 931651 (1955 to BASF). Toxicity studies: Miyake et al., Pharm. Bull. 1, 84, 89 (1953). Review: Caltrider, Antibiotics vol. I, D. Gottlieb, P. D. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 666-668.

Narbomycin CAS Registry Number: 6036-25-5 那波霉素

CAS Name: 12-Deoxypicromycin
Percent Composition: C 65.98%, H 9.29%, N 2.75%, O 21.97%
Literature References: Antibiotic substance produced by Streptomyces narbonensis from soil near Cannes, France: Corbaz et al., Helv. Chim. Acta 38, 935 (1955). Structure: Prelog et al., ibid. 45, 4 (1962). Stereochemical studies: Rickards, Smith, Tetrahedron Lett. 1970, 1025; H. Ogura et al., J. Am. Chem. Soc. 97, 1930 (1975); eidem, Tetrahedron 37, Suppl. 1, 165 (1981). Isoln and structure of the aglycone narbonolide: Hori et al., Chem. Commun. 1971, 304. Synthesis of narbonolide: T. Kaiho et al., J. Org. Chem. 47, 1612 (1982).

Hydroxystreptomycin CAS Registry Number: 6835-00-3

Additional Names: Reticulin (the antibiotic)
Percent Composition: C 42.21%, H 6.58%, N 16.41%, O 34.81%
Literature References: Antibiotic substance produced by Streptomyces reticuli: Hosoya et al., Jpn. J. Exp. Med. 20, 327 (1949), C.A. 45, 3459i (1951); by S. griseocarneus (from a Japanese soil): Stodola et al., J. Am. Chem. Soc. 73, 2290 (1951); Benedict, Stodola, US 2617755 (1952 to U.S. Secy. Agr.); by Streptomyces NA 232-M1: Grundy et al., Antibiot. Chemother. 1, 309 (1951); by S. subrutilus: Arai et al., J. Antibiot. 17A, 23 (1964). Identity of reticulin (the antibiotic) and hydroxystreptomycin: Hosoya et al., Jpn. J. Exp. Med. 22, 303 (1952), C.A. 48, 3477a (1954). Toxicity: Ambrose, Proc. Soc. Exp. Biol. Med. 76, 466 (1951).

Aureothricin CAS Registry Number: 574-95-8 金丝菌素

CAS Name: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propanamide
Additional Names: 4-methyl-6-propionamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one; 5-methyl-3-propionamidopyrrolin...
Literature References: Antibiotic substance produced by Streptomyces sp 26A (Mitaka, Tokyo, June 1947) which resembles Nocardia farcinicus or Streptomyces lipmanii: Umezawa et al., Jpn. Med. J. 1, 512 (1948); Umezawa et al., J. Antibiot. 2, Suppl. A, 105 (1949); Maeda, ibid. 2, 793 (1949); Maeda, Jpn. Med. J. 2, 85 (1949); Celmer et al., J. Am. Chem. Soc. 74, 6304 (1952). Structure: Celmer, Solomons, ibid. 77, 2861 (1955). Prepn: Celmer, US 2752359 (1956 to Pfizer). Total synthesis: Schmidt, Geiger, Angew. Chem. 74, 328 (1962).

Novobiocin CAS Registry Number: 303-81-1 新生霉素

CAS Name: N-[7-[[3-O-(Aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-b-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)benzamide
Additiona...
Literature References: Antibiotic substance produced by Streptomyces spheroides: Kaczka et al., J. Am. Chem. Soc. 77, 6404 (1955); Wolf, US 3000873 (1961 to Merck Co.); Stammer, Miller; Miller; Wallick, US 3049475; US 3049476; US 3049534 (all 1962 to Merck Co.). By Streptomyces niveus: Hoeksema et al., J. Am. Chem. Soc. 77, 6710 (1955); Antibiot. Chemother. 6, 143 (1956); French, US 3068221 (1962 to Upjohn). Structure: Shunk et al., J. Am. Chem. Soc. 78, 1770 (1956); Hoeksema et al., ibid. 2019; Walton et al., ibid. 82, 1489 (1960). Conformation: Golding, Richards, Chem. Ind. (London) 1963, 1081. Revised configuration: O. Achmatowicz et al., Tetrahedron 32, 1051 (1976). Synthesis: Stammer, US 2925411 (1960); Walton, Spencer, US 2966484 (1960 to Merck Co.); Vaterlaus et al., Helv. Chim. Acta 47, 390 (1964). Conversion of isonovobiocin to novobiocin: Caron et al., US 2983723 (1961 to Upjohn). Antiviral activity: Chang, Weinstein, Antimicrob. Agents Chemother. 1970, 165. Efficacy in canine respiratory infections: B. W. Maxey, Vet. Med. Small Anim. Clin. 75, 89 (1980). Mechanism of action studies: Smith, Davis, J. Bacteriol. 93, 71 (1967); H. T. Wright et al., Science 213, 455 (1981); I. W. Althaus et al., J. Antibiot. 41, 373 (1988). Review: Brock in Antibiotics vol. 1, R. Gottlieb, P. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 651-665; M. J. Ryan, ibid. vol. 5(pt. 1), F. E. Hahn, Ed. (1979) pp 214-234.