Cycloserine CAS Registry Number: 68-41-7 D-环丝氨酸
CAS Name: D-4-Amino-3-isoxazolidinone
Additional Names: D-4-amino-3-isoxazolidone; orientomycinTrademarks: Closina; Farmiserina (Farmitalia); Micoserina; Oxamycin (Merck Co.); Seromycin (Lilly)
Percent Composition: C 35.29%, H 5.92%, N 27.44%, O 31.34%
📌 参考资料/链接：
Literature References: Antibiotic substance produced by Streptomyces garyphalus sive orchidaceus: Kuehl, Jr., et al., J. Am. Chem. Soc. 77, 2344 (1955); Hidy et al., ibid. 2345; Shull, Sardinas, Antibiot. Chemother. 5, 398 (1955); Shull et al., US 2773878 (1956 to Pfizer); Harned, US 2789983 (1957 to Commercial Solvents); GB 768007 (1957 to Commercial Solvents), C.A. 51, 10847e (1957); US 3124590 (1964 to Commercial Solvents); Howe, US 2845433 (1958 to Merck Co.). Synthesis: Stammer et al., J. Am. Chem. Soc. 77, 2346 (1955); Peck, US 2772280 (1956 to Merck Co.); Plattner et al., Helv. Chim. Acta 40, 1531 (1957); Holly, Stammer, US 2840565 (1958 to Merck Co.). Prepn of crystalline calcium and magnesium salts: Harris et al., US 2832788 (1958 to Merck Co.). HPLC determn in plasma and urine: D. G. Musson et al., J. Chromatogr. 414, 121 (1987). Comprehensive description: J. W. Lamb, Anal. Profiles Drug Subs. 1, 53-64 (1972); H. A. El-Obeid, A. A. Al-Badr, ibid. 18, 567-597 (1989).
📄 详细内容
Properties: Crystals, decomp 155-156°. [a]D23 +116° (c = 1.17); [a]25546 +137° (c = 5 in 2N NaOH). uv max: 226 nm (E1%1cm 402). Sol in water, slightly sol in methanol, propylene glycol. Aq solns have a pH around 6. Forms salts with acids and bases. Neutral or acid solns are unstable. Aq solns buffered to pH 10 with sodium carbonate can be stored without loss for one week at refrigerator temps.
Optical Rotation: [a]D23 +116° (c = 1.17); [a]25546 +137° (c = 5 in 2N NaOH)
Absorption maximum: uv max: 226 nm (E1%1cm 402)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Antibiotics); Antibacterial (Tuberculostatic).
产品链接: 68-41-7››