其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Phthiocol CAS Registry Number: 483-55-6 2-羟基-3-甲基-1,4-二氢萘-1,4-二酮

CAS Name: 2-Hydroxy-3-methyl-1,4-naphthalenedione
Additional Names: 2-hydroxy-3-methyl-1,4-naphthoquinone
Percent Composition: C 70.21%, H 4.29%, O 25.51%
Literature References: Antibiotic substance produced by Mycobacterium tuberculosis: Terni, Boll. Soc. Ital. Biol. Sper. 25, 60 (1949), C.A. 45, 2054f (1951). Possesses some vitamin K activity. Isoln and synthesis: Anderson, Newman, J. Biol. Chem. 101, 773 (1933); 103, 197, 405 (1933); L. F. Fieser, ibid. 133, 391 (1940); Tarbell et al., J. Am. Chem. Soc. 72, 379 (1950); Burton, Praill, J. Chem. Soc. 1952, 755; Eistert, Müller, Ber. 92, 2071 (1959); H. Kallmayer, Arch. Pharm. 307, 806 (1974); K. Maruyama, S. Arakawa, J. Org. Chem. 42, 3793 (1977).

Mycomycin CAS Registry Number: 544-51-4 (3E,5Z)-3,5,7,8-十三碳四烯-10,12-二炔酸

CAS Name: 3,5,7,8-Tridecatetraene-10,12-diynoic acid
Percent Composition: C 78.77%, H 5.08%, O 16.14%
Literature References: Antibiotic substance produced by Nocardia acidophilus: Johnson, Burdon, J. Bacteriol. 54, 281 (1947); Johnson, Soc. Am. Bacteriologists, 49th General Meeting (May, 1949), Abstracts of Papers, p 68; Celmer, Solomons, 121st A.C.S. Meeting (Milwaukee, 1952), Abstracts of Papers, p 17-J; J. Am. Chem. Soc. 74, 1870, 2245 (1952); 75, 1372 (1953). Synthesis: Bohlmann, Sucrow, Angew. Chem. 76, 611 (1964).

Citromycetin CAS Registry Number: 478-60-4 柠檬菌素

CAS Name: 8,9-Dihydroxy-2-methyl-4-oxo-4H,5H-pyrano[3,2-c][1]benzopyran-10-carboxylic acid
Additional Names: frequentic acid
Percent Composition: C 57.94%, H 3.47%, O 38.59%
Literature References: Antibiotic substance produced by Penicillium frequentans Westling and P. vesiculosum Bainier and by Citromyces spp: Hetherington, Raistrick, Philos. Trans. R. Soc. London Ser. B 220, 209 (1931); Grove, Brian, Nature 167, 995 (1951). Structure: Robertson et al., J. Chem. Soc. 1951, 2013. Biosynthesis: Birch et al., ibid. 1958, 4576; Money, Nature 199, 592 (1963). Total synthesis: M. Yamauchi et al., J. Chem. Soc. Perkin Trans. 1 1987, 395.

Griseofulvin CAS Registry Number: 126-07-8 灰黄霉素

CAS Name: (1'S,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
Additional Names: 7-chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'-met...
Literature References: Antibiotic substance produced by Penicillium griseofulvum Dierckx and by P. janczewskii Zal. [same as P. nigricans (Banier)Thom]. Isoln: Oxford et al., Biochem. J. 33, 240 (1939); Brian et al., Trans. Br. Mycol. Soc. 29, 173 (1946); Hockenhull, Dorey et al., US 3069328, US 3069329 (both 1962 to Glaxo). Structure: Grove et al., Chem. Ind. (London) 1951, 219; J. Chem. Soc. 1952, 3977. Stereochemistry: MacMillan, ibid. 1959, 1823; Brown, Sim, ibid. 1963, 1050. Total synthesis: Brossi et al., Helv. Chim. Acta 43, 1444, 2071 (1960); Taub et al., Tetrahedron 19, 1 (1963); Stork, Tomasz, J. Am. Chem. Soc. 86, 471 (1964); S. Danishefsky, F. J. Walker, ibid. 101, 7018 (1979). Conformation: Levine, Hicks, Tetrahedron Lett. 1971, 311. Crystal structure: G. Malmros et al., Cryst. Struct. Commun. 6, 463 (1977). Review and evaluation of studies of carcinogenic action in laboratory animals: IARC Monographs 10, 153-161 (1976). Review: Grove, Q. Rev. Chem. Soc. 17, 1 (1963); Huber in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 606-613. Comprehensive description: E. R. Townley, Anal. Profiles Drug Subs. 8, 219-249 (1979).

Puberulonic Acid CAS Registry Number: 82-83-7

CAS Name: 5,6,7-Trihydroxy-1H-cyclohepta[c]furan-1,3,4-trione
Additional Names: 4,5,6-trihydroxy-7-oxo-1,3,5-cycloheptatriene-1,2-dicarboxylic anhydride
Percent Composition: C 48.23%, H 1.80...
Literature References: Antibiotic substance produced by Penicillium puberulum, P. aurantiovirens, P. johannioli, P. cyclopium viridicatum. Isoln: Birkinshaw, Raistrick, Biochem. J. 26, 441 (1932); Barger, Dorrer, ibid. 28, 11 (1934). Structure: McGowan, Chem. Ind. (London) 1947, 205; Aulin-Erdtman, Acta Chem. Scand. 4, 1325 (1950). Johnson et al., J. Chem. Soc. 1951, 1139. Synthesis: Nozoe et al., Bull. Chem. Soc. Jpn. 33, 1071 (1960). Biosynthesis: Ferritti, Richards, Proc. Natl. Acad. Sci. USA 46, 1438 (1960); A. I. Scott, E. Lee, Chem. Commun. 1972, 655. Review: Nozoe, Fortschr. Chem. Org. Naturst. 13, 232-301 (1956).

Puberulic Acid CAS Registry Number: 99-23-0 4,5,6-三羟基-3-氧代-1,4,6-环庚三烯-1-羧酸

CAS Name: 3,4,6-Trihydroxy-5-oxo-1,3,6-cycloheptatriene-1-carboxylic acid
Percent Composition: C 48.50%, H 3.05%, O 48.45%
Literature References: Antibiotic substance produced by Penicillium puberulum, P. aurantiovirens, P. johannioli, P. cyclopium viridicatum. Isoln: Birkinshaw, Raistrick, Biochem. J. 26, 441 (1932); Barger, Dorrer, ibid. 28, 11 (1934). Structure: McGowan, Chem. Ind. (London) 1947, 205; Corbett et al., ibid. 1949, 626; J. Chem. Soc. 1950, 6. Synthesis: Johns et al., ibid. 1954, 198. Biosynthesis: Ferretti, Richards, Proc. Natl. Acad. Sci. USA 46, 1438 (1960). Review: Nozoe, Fortschr. Chem. Org. Naturst. 13, 232-301 (1956).

Viscosin CAS Registry Number: 27127-62-4 (4R)-5-[[(3S,6R,9S,12R,15S,18R,21S)-6,12-二(羟甲基)-9,15-二异丁基-18-异丙基-22-甲基-2,5,8,11,14,17,20-七羰基-3-仲-丁基-1-氧杂-4,7,10,13,16,19-六氮杂环二十二碳-21-基]氨基]-4-[[(2S)-2-(3-羟基壬酰氨基)-4-甲基-戊酰基]氨基]-5-o

Percent Composition: C 57.58%, H 8.50%, N 11.19%, O 22.73%
Literature References: Antibiotic substance produced by Pseudomonas viscosa. Isoln: Kochi et al., Bact. Proc. 1951, 29; Groupé et al., Proc. Soc. Exp. Biol. Med. 78, 354 (1951); Ohno et al., J. Agric. Chem. Soc. Jpn. 27, 665 (1953); C.A. 49, 3012 (1955); Toki, Ohno, C.A. 53, 243b (1959). Synthesis studies: Fukuda, Bani, C.A. 56, 10265i (1962). Structure: Toki, Ohno, loc. cit. Revised structure: Hiramoto et al., Tetrahedron Lett. 1970, 1087; eidem, Chem. Pharm. Bull. 19, 1308, 1315 (1971). Shows antitubercular activity.

Indolmycin CAS Registry Number: 21200-24-8 (-)-吲哚霉素

CAS Name: (5S)-5-[(1R)-1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-4(5H)-oxazolone
Additional Names: (1R,5S)-5-(1-indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one; 2-methylamino-5a-(b-indolyl)ethy...
Literature References: Antibiotic substance produced by Streptomyces albus: Rao, Antibiot. Chemother. 10, 312 (1960); Marsh et al., ibid. 316; GB 862685 (1961 to Pfizer). Structure: M. Schach von Wittenau, H. Els, J. Am. Chem. Soc. 83, 4678 (1961). Total synthesis: eidem, ibid. 85, 3425 (1963); Preobrazhenskaya et al., Tetrahedron 24, 6131 (1968); T. Takeda, T. Mukaiyama, Chem. Lett. 1980, 163. Abs config: T. H. Chan, R. K. Hill, J. Org. Chem. 35, 3519 (1970). Biosynthetic studies: Hornemann et al., Chem. Commun. 1969, 245; eidem, J. Am. Chem. Soc. 93, 3028 (1971).

Oleandomycin CAS Registry Number: 3922-90-5 竹桃霉素

Trademarks: Amimycin; Landomycin; Romicil
Percent Composition: C 61.11%, H 8.94%, N 2.04%, O 27.91%
Literature References: Antibiotic substance produced by Streptomyces antibioticus no. ATCC 11891: Sobin et al.; Ratajak, Nubel, US 2757123; US 2842481 (1956, 1958 to Pfizer). Structure: Hochstein et al., J. Am. Chem. Soc. 82, 3225 (1960). Absolute configuration: Celmer, ibid. 87, 1797 (1965); Celmer, Hobbs, Carbohydr. Res. 1, 137 (1965); S. Omura et al., Tetrahedron Lett. 1975, 2939. Synthetic study: K. Tatsuta et al., ibid. 29, 3975 (1988). Activity: Hahn, Antibiotics 1, 378, 755 (1967). For a review of macrolide antibiotics see Keller-Schierlein, Fortschr. Chem. Org. Naturst. 30, 313-460 (1973). Toxicity: H. Sous et al., Arzneim.-Forsch. 8, 386 (1958).

Celesticetin CAS Registry Number: 2520-21-0 2-[(2S,3S,4R,5R,6S)-3,4,5-三羟基-6-[(1R,2R)-2-甲氧基-1-[[(2S)-1-甲基吡咯烷-2-羰基]氨基]丙基]四氢吡喃-2-基]巯基乙基2-羟基苯甲酸酯

CAS Name: 2-[(2-Hydroxybenzoyl)oxy]ethyl 6,8-dideoxy-7-O-methyl-6-[[[(2S)-1-methyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-a-D-galacto-octopyranoside
Additional Names: a-2-hydroxyethyl ...
Literature References: Antibiotic substance produced by Streptomyces caelestis from a soil obtained from Emigration Canyon near Salt Lake City: DeBoer et al., Antibiot. Annu. 1954-1955, 831; Hoeksema et al., ibid. 837. Structure: Hoeksema, J. Am. Chem. Soc. 86, 4224 (1964); 90, 755 (1968).