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Oleandomycin CAS Registry Number: 3922-90-5 竹桃霉素

Trademarks: Amimycin; Landomycin; Romicil
Percent Composition: C 61.11%, H 8.94%, N 2.04%, O 27.91%
📌 参考资料/链接：
Literature References: Antibiotic substance produced by Streptomyces antibioticus no. ATCC 11891: Sobin et al.; Ratajak, Nubel, US 2757123; US 2842481 (1956, 1958 to Pfizer). Structure: Hochstein et al., J. Am. Chem. Soc. 82, 3225 (1960). Absolute configuration: Celmer, ibid. 87, 1797 (1965); Celmer, Hobbs, Carbohydr. Res. 1, 137 (1965); S. Omura et al., Tetrahedron Lett. 1975, 2939. Synthetic study: K. Tatsuta et al., ibid. 29, 3975 (1988). Activity: Hahn, Antibiotics 1, 378, 755 (1967). For a review of macrolide antibiotics see Keller-Schierlein, Fortschr. Chem. Org. Naturst. 30, 313-460 (1973). Toxicity: H. Sous et al., Arzneim.-Forsch. 8, 386 (1958).

📄 详细内容


Properties: White amorphous powder. uv max (methanol): 286-289 nm. Moderately sol in water. Sol in dil acids. Freely sol in methanol, ethanol, butanol, acetone. Practically insol in hexane, carbon tetrachloride, dibutyl ether.
Absorption maximum: uv max (methanol): 286-289 nm
Derivative Type: Hydrochloride
CAS Registry Number: 6696-47-5
Percent Composition: C 58.04%, H 8.63%, N 1.93%, O 26.51%, Cl 4.89%
Properties: Long needles from ethyl acetate, mp 134-135°. [a]D25 -54° (methanol). Freely sol in water. Forms various cryst hydrates. LD50 in mice, rats (mg/kg): 8200, 10000 orally; 600, 400 i.v. (Sous).
Melting point: mp 134-135°
Optical Rotation: [a]D25 -54° (methanol)
Toxicity data: LD50 in mice, rats (mg/kg): 8200, 10000 orally; 600, 400 i.v. (Sous)
Derivative Type: Phosphate
CAS Registry Number: 7060-74-4
Trademarks: Matromycin (Pfizer)
Percent Composition: C 53.49%, H 8.21%, N 1.78%, O 32.57%, P 3.94%
Derivative Type: Triacetyl deriv see Troleandomycin
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.
产品链接: 3922-90-5››
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