其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Nybomycin CAS Registry Number: 30408-30-1 8-(羟基甲基)-6,11-二甲基-4H-[1,3]恶唑并[5,4,3-ij]吡啶并[3,2-g]喹啉-4,10(11H)-二酮

CAS Name: 8-(Hydroxymethyl)-6,11-dimethyl-2H,4H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione
Additional Names: 6,11-dimethyl-8-(hydroxymethyl)pyrido[3,2-g]oxazolo[5,4,3-ij]quinoline-...
Literature References: Antibiotic substance produced by Streptomycete A 717 isolated from Missouri soil: Strelitz et al., Proc. Natl. Acad. Sci. USA 41, 620 (1955); Eble et al., Antibiot. Chemother. 8, 627 (1958); Brock, Sokolski, ibid. 631. Structure: Rinehart, Renfroe, J. Am. Chem. Soc. 83, 3729 (1961). Revised structure: Rinehart et al., ibid. 92, 6994 (1970). Total synthesis of deoxynybomycin: Forbis, Rinehart, ibid. 6995. Total synthesis of nybomycin: eidem, J. Antibiot. 24, 326 (1971); eidem, J. Am. Chem. Soc. 95, 5003 (1973).

Diatretyne II CAS Registry Number: 3625-68-1

CAS Name: 7-Cyano-2-heptene-4,6-diynoic acid
Additional Names: diatretyne nitrile; nudic acid B
Percent Composition: C 66.22%, H 2.08%, N 9.65%, O 22.05%
Literature References: Antibiotic substance produced by the basidiomycete Tricholoma nudum and by the fungus Clitocybe diatreta. Isoln: Anchel, J. Am. Chem. Soc. 74, 1588 (1952). Structure: Anchel, Science 121, 607 (1955). Identity of nudic acid B and diatretyne II: Heatly, Stephenson, Nature 179, 1078 (1957). Synthesis: Ashworth et al., J. Chem. Soc. 1958, 950.

Pleuromutilin CAS Registry Number: 125-65-5 截短侧耳素

CAS Name: Hydroxyacetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
Additional Names: glycolic aci...
Literature References: Antibiotic substance produced by the basidiomycetes Pleurotus mutilus (Fr.) Sacc. and P. passeckerianus Pilat.: Kavanagh et al., Proc. Natl. Acad. Sci. USA 37, 570 (1951); 38, 555 (1952). Isoln procedure: Anchel, J. Biol. Chem. 199, 133 (1952). Structure: D. Arigoni, Gazz. Chim. Ital. 92, 884 (1962); A. J. Birch et al., Chem. Ind. (London) 1963, 374; Tetrahedron Suppl. 8, 359 (1966). Stereochemistry: D. Arigoni, Pure Appl. Chem. 17, 331 (1968). Fermentation and biosynthetic study: F. Knauseder, E. Brandl, J. Antibiot. 29, 125 (1976). Mechanism of action: G. Hoegenauer, Antibiotics vol. 5, pt. 1, F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) p 344. Synthetic studies: E. G. Gibbons, J. Org. Chem. 45, 1540 (1980); M. Kahn, Tetrahedron Lett. 21, 4547 (1980). Total synthesis: E. G. Gibbons, J. Am. Chem. Soc. 104, 1767 (1982).

Diatretyne I CAS Registry Number: 53318-35-7

CAS Name: (E)-8-Amino-8-oxo-2-octene-4,6-diynoic acid
Additional Names: trans-7-carbamoyl-2-heptene-4,6-diynoic acid; 7-carbamidohepta-2-ene-4,6-diynoic acid; diatretyne amide
Percent Compos...
Literature References: Antibiotic substance produced by the fungus Clitocybe diatreta: Anchel, J. Am. Chem. Soc. 75, 4621 (1953); Arch. Biochem. Biophys. 78, 100 (1958). Structure: Bu'Lock et al., Chem. Ind. (London) 1954, 990. Synthesis: Ashworth et al., J. Chem. Soc. 1958, 950; Prevost et al., Bull. Soc. Chim. Fr. 1961, 2171.

Pleurotin(e) CAS Registry Number: 1404-23-5

CAS Name: (2aa,4ab,5b,6b,8aa,12bb,12cb,12db)-(-)-2a,3,4,4a,5,6,7,8a,12b,12c-Decahydro-6-methyl-2H-5,12d-ethanofuro[4',3',2':4,10]anthra[9,1-bc]oxepin-2,9,12-trione
Percent Composition: C 71.17%...
Literature References: Antibiotic substance produced by the fungus Pleurotus griseus: Robbins et al., Bull. Torrey Bot. Club 72, 165 (1945). Isoln: Robbins et al., Proc. Natl. Acad. Sci. USA 33, 171 (1947). Partial structure: Huls, Publ. Univ. Congo Elisabethville 4, 109 (1962), C.A. 3894f (1965). Structure and stereochemistry: J. Grandjean, R. Huls, Tetrahedron Lett. 1974, 1893. Synthesis of racemate: D. J. Hart, H.-C. Huang, J. Am. Chem. Soc. 110, 1634 (1988).

Sparassol CAS Registry Number: 520-43-4 甲基2-羟基-4-甲氧基-6-甲基苯甲酸酯

CAS Name: 2-Hydroxy-4-methoxy-6-methylbenzoic acid methyl ester
Additional Names: 4-methoxy-2,6-cresotic acid methyl ester; everninic acid methyl ester; orsellinic acid methyl ester 4-methyl et...
Literature References: Antibiotic substance produced by the fungus Sparassis ramosa: Falck, Ber. 56, 2555 (1923). Also obtained in methanol extracts of the lichen Evernia prunasti: Stenhouse, Ann. 68, 55 (1848); Späth, Jeschki, Ber. 57, 471 (1924). Structure: Fischer, Hoesch, Ann. 391, 347 (1912); Wedekind, Fleischer, Ber. 56, 2556 (1923). Synthesis: G. Nicollier et al., Helv. Chim. Acta 61, 2899 (1978).

Cinnabarine CAS Registry Number: 146-90-7 2-氨基-9-(羟基甲基)-3-氧代吩恶嗪-1-羧酸

CAS Name: 2-Amino-9-hydroxymethyl-3-oxo-3H-phenoxazine-1-carboxylic acid
Additional Names: 1-carboxy-2-amino-9-hydroxymethylphenoxazin-3-one; polystictine
Percent Composition: C 58.74%, H 3....
Literature References: Antibiotic substance produced by the fungus Trametes cinnabarina Jacq.: Gripenberg, Acta Chem. Scand. 5, 590 (1951); from Coriolus sanguineus (Fr.) (Polystictus cinnabarinus Jacq.): Cavill et al., J. Chem. Soc. 1953, 525. Identity with polystictine: Gripenberg et al., Acta Chem. Scand. 11, 1485 (1957). Structure: Gripenberg, ibid. 12, 603 (1958); 13, 1305 (1959); Cavill et al., Tetrahedron 5, 275 (1959). Syntheses: Weinstein, Brattesani, J. Heterocycl. Chem. 4, 151 (1967); Schäfer, Schlude, Tetrahedron Lett. 1968, 2161.

Gliotoxin CAS Registry Number: 67-99-2 胶霉毒素

CAS Name: (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
Percent Composition: C 47.84%, H 4.32%, N 8.58%, O 19.61%,...
Literature References: Antibiotic substance produced by various spp of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium spp: Weindling, Emerson, Phytopathology 26, 1068 (1936); 27, 1175 (1937); Johnson et al., J. Am. Chem. Soc. 65, 2005 (1943); Menzel et al., J. Biol. Chem. 152, 419 (1944). Structure: Bell et al., J. Am. Chem. Soc. 80, 1001 (1958); Beecham et al., Tetrahedron Lett. 1966, 3131. Crystallographic data: McCrone, Anal. Chem. 26, 1662 (1954). Biosynthesis: Suhadolnik, Chenoweth, J. Am. Chem. Soc. 80, 4391 (1958); Winstead, Suhadolnik, ibid. 82, 1644 (1960); J. D. M. Herscheid et al., J. Org. Chem. 45, 1885 (1980). Synthetic studies: Poisel, Schmidt, Ber. 104, 1714 (1971); ibid. 105, 625 (1972); Oehler et al., ibid. 625. Total synthesis of dl-form: T. Fukuyama, Y. Kishi, J. Am. Chem. Soc. 98, 6723 (1976); T. Fukuyama et al., Tetrahedron 37, 2045 (1981).

Chalcomycin CAS Registry Number: 20283-48-1 查耳霉素A

Percent Composition: C 59.98%, H 8.05%, O 31.96%
Literature References: Antibiotic substance produced from Streptomyces bikiniensis NRRL 2737: Frohardt et al., DE 1109835 (1960 to Parke, Davis). Structure: Woo et al., J. Am. Chem. Soc. 86, 2726 (1964). Review: Jordan, "Chalcomycin" in Antibiotics I, D. Gottlieb, P. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 446-450.

Tubercidin CAS Registry Number: 69-33-0 杀结核菌素

CAS Name: 7-b-D-Ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Additional Names: 4-amino-7-b-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine; 7-deazaadenosine; sparsamycin APercent Composition: C...
Literature References: Antibiotic substance produced in the culture broth of Streptomyces tubericidus. Isoln: Anzai et al., J. Antibiot. 10A, 201 (1957). Structure: Susuki, Marumo, ibid. 14A, 34 (1961). Total synthesis: Tolman et al., J. Am. Chem. Soc. 91, 2102 (1969). Crystal structure: Stroud, Acta Crystallogr. 29B, 690 (1973); Abola, Sundaralingham, ibid. 697.