其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Apoatropine CAS Registry Number: 500-55-0 阿朴阿托品

CAS Name: endo-a-Methylenebenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Additional Names: 1aH,5aH-tropan-3a-ol atropate; atropamine; atropyltropeine
Percent Composition: C 75...
Literature References: Anticholinergic. Occurs in root of Atropa belladonna L., Solanaceae. Also obtained from atropine by splitting off water or by total synthesis: Ladenburg, Ann. 217, 102 (1883); Merck, Arch. Pharm. 230, 134 (1892); 231, 110 (1893); Hesse, Ann. 261, 87 (1891); 271, 124 (1892); 277, 290 (1893). Isoln by chromatography: Steinegger, Phokas, Pharm. Acta Helv. 31, 284 (1956).

Propyromazine CAS Registry Number: 145-54-0 溴吡马嗪

CAS Name: 1-Methyl-1-[1-methyl-2-oxo-2-(10H-phenothiazin-10-yl)ethyl]pyrrolidinium bromide
Additional Names: 1-methyl-1-[1-(phenothiazin-10-ylcarbonyl)ethyl]pyrrolidinium bromide; 10-[2-(1-meth...
Literature References: Anticholinergic. Prepd by N-acylation of phenothiazine: Boissier et al., Therapie 13, 989 (1958). Prepn of the free base from 10-(a-bromopropionyl)phenothiazine and pyrrolidine: Dahlbom, Ekstrand, Acta Chem. Scand. 5, 102 (1951); eidem, US 2615886 (1952 to Astra).

Benztropine Mesylate CAS Registry Number: 132-17-2 苯扎托品

CAS Name: 3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate
Additional Names: 3a-(diphenylmethoxy)-1aH,5aH-tropane methanesulfonate; benztropine methanesulfonate; tropine ...
Literature References: Anticholinergic. Prepd by the action of diphenyldiazomethane on tropine: Phillips, US 2595405 (1952 to Merck Co.). Crystal structure: P. G. Jones et al., Acta Crystallogr. B34, 3125 (1978).

Methscopolamine Bromide CAS Registry Number: 155-41-9 甲溴东莨菪碱

CAS Name: (1a,2b,4b,5a,7b)-7-[(2S)-3-Hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Additional Names: 6b,7b-epoxy-3a-hydroxy-8-methyl-1aH,5aH-tropa...
Literature References: Anticholinergic. Prepd by the action of methyl bromide on scopolamine base: Visscher, US 2753288 (1956 to Upjohn). Treatment of duodenal ulcer by transdermally administered methscopolamine bromide: R. P. Walt et al., Br. Med. J. 284, 1736 (1982).

Cycrimine Hydrochloride CAS Registry Number: 126-02-3 盐酸赛克立明

CAS Name: a-Cyclopentyl-a-phenyl-1-piperidinepropanol hydrochloride
Additional Names: 1-phenyl-1-cyclopentyl-3-piperidino-1-propanol hydrochlorideTrademarks: Pagitane hydrochloride (Lilly)
P...
Literature References: Anticholinergic. Prepd by the addition of a Grignard reagent to the corresponding b-aminoketone: Denton et al., J. Am. Chem. Soc. 72, 3795 (1950).

Dibutoline Sulfate CAS Registry Number: 532-49-0 Di-n-丁基-氨基胆碱硫酸盐

CAS Name: 2-[[(Dibutylamino)carbonyl]oxy]-N-ethyl-N,N-dimethylethanaminium sulfate (2:1)
Additional Names: bis[ethyl(2-hydroxyethyl)dimethylammonium] sulfate bis(dibutylcarbamate); (2-dibutyl-c...
Literature References: Anticholinergic. Prepd by treating dibutoline iodide with Ag2SO4: Swan, White, US 2408893 (1946); US 2432049 (1947).

Metcaraphen CAS Registry Number: 561-79-5 甲卡拉芬

CAS Name: 1-(3',4'-Dimethylphenyl)-1-cyclopentanecarboxylic acid 2-diethylaminoethyl ester
Additional Names: 2-diethylaminoethyl 1-(3',4'-dimethylphenyl)-1-cyclopentanecarboxylate
Percent Co...
Literature References: Anticholinergic. Prepd by treating the parent acid chloride with 2-diethylaminoethanol: Martin, Häfliger, US 2404588 (1946 to Geigy).

Benzilonium Bromide CAS Registry Number: 1050-48-2 苯咯溴铵

CAS Name: 1,1-Diethyl-3-[(hydroxydiphenylacetyl)oxy]pyrrolidinium bromide
Additional Names: 1-ethyl-3-pyrrolidinyl benzilate ethyl bromide; 3-benziloyloxy-1,1-diethylpyrrolidinium bromide; benz...
Literature References: Anticholinergic. Prepd from 1-ethyl-3-hydroxypyrrolidine and ethyl benzilate followed by reaction with ethyl bromide: Bowman et al., GB 821436 (1956 to Parke, Davis); Ryan, Ainsworth, J. Org. Chem. 27, 2901 (1962). Toxicity study: Reichertz, Schliva, Arzneim.-Forsch. 12, 414 (1962). GC-MS determn in plasma: H. Dahlström et al., J. Chromatogr. 183, 511 (1980). Clinical evaluation for duodenal ulcer: M. Hradsky, Scand. J. Gastroenterol. Suppl. 54, 52 (1979).

Piperidolate CAS Registry Number: 82-98-4 哌立度酯

CAS Name: a-Phenylbenzeneacetic acid 1-ethyl-3-piperidinyl ester
Additional Names: diphenylacetic acid 1-ethyl-3-piperidyl ester; N-ethyl-3-piperidyl diphenylacetatePercent Composition: C 77.98...
Literature References: Anticholinergic. Prepd from diphenylacetyl chloride and N-ethyl-3-hydroxypiperidine: Biel et al., J. Am. Chem. Soc. 74, 1485 (1952); US 2918407 (1959 to Lakeside Labs.).

Phencarbamide CAS Registry Number: 3735-90-8 芬卡米特

CAS Name: Diphenylcarbamothioic acid S-[2-(diethylamino)ethyl] ester
Additional Names: diphenylthiocarbamic acid S-[2-(diethylamino)ethyl] ester; S-[2-(diethylamino)ethyl] diphenylthiocarbamate...
Literature References: Anticholinergic. Prepd from diphenylcarbamyl chloride and b-diethylaminoethanethiol: GB 871774; K. H. Risse et al., US 3228949 (1961, 1966 both to Bayer). Pharmacology: W. Wirth et al., Arch. Int. Pharmacodyn. 151, 515 (1964); W. Wirth, R. Goesswald, ibid. 155, 393 (1965); B. R. Madan et al., ibid. 185, 53 (1970).