其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Pentapiperide CAS Registry Number: 7009-54-3 戊哌立特

CAS Name: a-(1-Methylpropyl)benzeneacetic acid 1-methyl-4-piperidinyl ester
Additional Names: 3-methyl-2-phenylvaleric acid 1-methyl-4-piperidyl ester; 2-phenyl-3-methylpentanoic acid 1-methyl-...
Literature References: Anticholinergic. Prepn: GB 781382 and Martin, Habicht, US 2987517 (1957, 1961 to Cilag).

Oxyphencyclimine CAS Registry Number: 125-53-1 羟苄利明

CAS Name: a-Cyclohexyl-a-hydroxybenzeneacetic acid (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester
Additional Names: 1,4,5,6-tetrahydro-1-methyl-2-pyrimidinylmethyl a-phenylcyclohexaneg...
Literature References: Anticholinergic. Prepn: GB 795758 (1958 to Pfizer); Faust et al., J. Am. Chem. Soc. 81, 2214 (1959).

Tiemonium Iodide CAS Registry Number: 144-12-7 替莫碘胺

CAS Name: 4-[3-Hydroxy-3-phenyl-3-(2-thienyl)propyl]-4-methylmorpholinium iodide
Additional Names: N-methyl-N-[3-hydroxy-3-phenyl-3-(a-thienyl)propyl]morpholinium iodide
Trademarks: Visceral...
Literature References: Anticholinergic. Prepn: GB 953386 (1964 to C.E.R.M.).

Benapryzine CAS Registry Number: 22487-42-9 贝那利秦

CAS Name: a-Hydroxy-a-phenylbenzeneacetic acid 2-(ethylpropylamino)ethyl ester
Additional Names: benzilic acid 2-(ethylpropylamino)ethyl ester; 2-(ethyl-n-propylamino)ethyl a,a-diphenylglycolat...
Literature References: Anticholinergic. Prepn: NL 6409696 corresp to M. D. Mehta, J. G. Bainbridge, US 3746743 (1963, 1973 to Beecham). Pharmacology: D. M. Brown et al., Nature 223, 416 (1969); C. Barthelemy et al., Therapie 27, 369 (1972); D. M. Brown et al., Br. J. Pharmacol. 47, 476 (1973). Metabolism: D. J. Jeffery et al., Xenobiotica 1, 169 (1971).

Amprotropine Phosphate CAS Registry Number: 134-53-2 安普洛托品

CAS Name: a-(Hydroxymethyl)benzeneacetic acid 3-(diethylamino)-2,2-dimethylpropyl ester phosphate (1:1) salt
Additional Names: 3-diethylamino-2,2-dimethylpropyl tropate phosphate
Trademarks:...
Literature References: Anticholinergic. Prepn: US 1932341 (1933); US 1987546 (1935).

Propenzolate CAS Registry Number: 4354-45-4 奥昔利平

CAS Name: a-Cyclohexyl-a-hydroxybenzeneacetic acid 1-methyl-3-piperidinyl ester
Additional Names: a-phenylcyclohexaneglycolic acid 1-methyl-3-piperidyl ester; 1-methyl-3-piperidyl a-phenylcyclo...
Literature References: Anticholinergic. Prepn: Biel et al., J. Org. Chem. 26, 4096 (1961); Biel, US 2995492 (1961 to Lakeside). Clinical effect on gastrointestinal motility: I. E. Danhof, Am. J. Gastroenterol. 48, 185 (1967).

Mepenzolate Bromide CAS Registry Number: 76-90-4 溴美喷酯

CAS Name: 3-[(Hydroxydiphenylacetyl)oxy]-1,1-dimethylpiperidinium bromide
Additional Names: N-methyl-3-piperidyl benzilate methyl bromide; N-methyl-3-piperidyl diphenylglycolate methobromide Literature References: Anticholinergic. Prepn: Biel, US 2918408 (1959 to Lakeside Labs.). Prepn of base: Biel et al., J. Am. Chem. Soc. 77, 2250 (1955). Crystal structure: J. M. Leger et al., Acta Crystallogr. B35, 886 (1979). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Methixene CAS Registry Number: 4969-02-2 1-甲基-3-(9H-噻吨-9-甲基)哌啶

CAS Name: 1-Methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
Additional Names: 9-(N-methyl-3-piperidylmethyl)thioxanthene
Percent Composition: C 77.62%, H 7.49%, N 4.53%, S 10.36%
Literature References: Anticholinergic. Prepn: Caviezel et al., Pharm. Acta Helv. 33, 447 (1958); J. Schmutz, US 2905590 (1959 to Wander). Metabolism and toxicity study: H. Lehner et al., Arzneim.-Forsch. 14, 89 (1964). Crystal structure: S. S. C. Chu, Acta Crystallogr. B28, 3625 (1972). Spectrofluorimetric determn: F. Belal et al., Anal. Chim. Acta 255, 103 (1991). Comprehensive description: E. M. Abdel-Moety et al., Anal. Profiles Drug Subs. Excip. 22, 317-358 (1993).

Poldine Methylsulfate CAS Registry Number: 545-80-2 甲硫泊尔定

CAS Name: 2-[[(Hydroxydiphenylacetyl)oxy]methyl]-1,1-dimethylpyrrolidinium methyl sulfate (salt)
Additional Names: 2-hydroxymethyl-1,1-dimethylpyrrolidinium methyl sulfate benzilate; 2-benziloy...
Literature References: Anticholinergic. Prepn: Doyle et al., J. Chem. Soc. 1958, 4458. Prepn of the base: Blicke, Lu, J. Am. Chem. Soc. 79, 29 (1955).

N-Butylscopolammonium Bromide CAS Registry Number: 149-64-4 丁溴酸东莨菪碱

CAS Name: [7(S)-(1a,2b,4b,5a,7b)]-9-Butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
Additional Names: a-(hydroxymethyl)benzeneacetic acid 9-b...
Literature References: Anticholinergic. Prepn: F. Adickes et al., DE 856890; eidem, US 2872452 (1952, 1959 both to Boehringer Ing.). Biological activity studies: Bauer et al., Arzneim.-Forsch. 18, 1132 (1968). Toxicological studies: K. Stockhaus, H. Wick, Arch. Int. Pharmacodyn. Ther. 180, 155 (1969). Use in endoscopic examinations: J. R. Lee, Clin. Radiol. 33, 273 (1982); D. N. Hupscher, O. Dommerholt, Diagn. Imag. Clin. Med. 53, 77 (1984); A. C. Steger et al., Am. J. Gastroenterol. 81, 615 (1986).