其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Xenytropium Bromide CAS Registry Number: 511-55-7 珍托溴铵

CAS Name: endo-(±)-8-([1,1'-Biphenyl]-4-ylmethyl)-3-(3-hydroxy-2-phenyl-1-oxopropoxy)-8-methyl-8-azoniabicyclo[3.2.1]octane bromide
Additional Names: 3a-hydroxy-8-(p-phenylbenzyl)-1aH,5aH-...
Literature References: Anticholinergic. Prepn: Nador, Gyermek, US 2833773 (1958 to Licencia-Budapest).

Isopropamide Iodide CAS Registry Number: 71-81-8 异丙碘胺

CAS Name: g-(Aminocarbonyl)-N-methyl-N,N-bis(1-methylethyl)-g-phenylbenzenepropanaminium iodide
Additional Names: (3-carbamoyl-3,3-diphenylpropyl)diisopropylmethylammonium iodide; 2,2-diphenyl-...
Literature References: Anticholinergic. Prepn: P. Janssen et al., Arch. Int. Pharmacodyn. 103, 82 (1955); M. E. Speeter, US 2823233 (1958 to Bristol). Crystal and molecular structure: N. Datta et al., J. Chem. Soc. Perkin Trans. 2 1977, 781. Comprehensive description: R. S. Santoro et al., Anal. Profiles Drug Subs. 2, 315-338 (1973); A. Post, R. S. Santoro, ibid. 12, 721-732 (1983).

Difemerine CAS Registry Number: 80387-96-8 双苯美林

CAS Name: a-Hydroxy-a-phenylbenzeneacetic acid 2-(dimethylamino)-2-methylpropyl ester
Additional Names: 2-(dimethylamino)-1,1-dimethylethyl benzilate
Percent Composition: C 73.37%, H 7.70%, ...
Literature References: Anticholinergic. Prepn: S. G. Kuznetsov, A. G. El'tsov, Zh. Obshch. Khim. 32, 511 (1962), C.A. 58, 470d (1963); C. Hoffmann, FR M3406 (1965 to Labs. U.P.S.A.), C.A. 63, 13163ab (1965). Toxicity: S. N. Golikov, S. G. Kuznetsov, C.A. 61, 8790b (1964). Comparison of side effects with those of atropine: L. Moser, P. V. Lundt, Med. Welt 31, 1795 (1980). Crystal structure: A. Carpy et al., Acta Crystallogr. B35, 882 (1979).

Butropium Bromide CAS Registry Number: 29025-14-7 布托溴铵

CAS Name: [3(S)-endo]-8-[(4-Butoxyphenyl)methyl]-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-azoniabicyclo[3.2.1]octane bromide
Additional Names: 8-(p-butoxybenzyl)-3a-hydroxy-1aH,5aH-tropan...
Literature References: Anticholinergic. Prepn: S. Tanaka, K. Hashimoto, DE 1950378; eidem, US 3696110 (1970, 1972 both to Eisai); Tanaka et al., J. Pharm. Soc. Jpn. 92, 510 (1972). Prepn of the labelled compound: Fujita et al., J. Labelled Compd. 9, 149, 555 (1972). Activity: Akutsu, Ichikawa, Showa Igakkai Zasshi 32, 494 (1972), C.A. 78, 119243g (1973).

Sultroponium CAS Registry Number: 15130-91-3 舒托泊铵

CAS Name: endo-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(3-sulfopropyl)-8-azoniabicyclo[3.2.1]octane inner salt
Additional Names: 3a-hydroxy-8-(3-sulfopropyl)-1aH,5aH-tropanium h...
Literature References: Anticholinergic. Prepn: Savini et al., Therapie 22, 843 (1967); Wahl, Prod. Probl. Pharm. 25, 260 (1970); Raudnitz et al., BE 672926 (1966) and GB 1082445 (1967).

Camylofine CAS Registry Number: 54-30-8 卡米罗芬

CAS Name: a-[[2-(Diethylamino)ethyl]amino]benzeneacetic acid 3-methylbutyl ester
Additional Names: N-[2-(diethylamino)ethyl]-2-phenylglycine isopentyl ester; isoamyl a-[N-(b-diethylaminoethyl)a...
Literature References: Anticholinergic. Prepn: Schmeisser et al., DE 842206 (1952 to Asta), C.A. 47, 5445i (1953); GB 688331 (1953); Chielmetti, Farm. Sci. Tec. 7, 625 (1952), C.A. 47, 11161 (1953); Edwards et al., J. Pharm. Pharmacol. 12, 179 (1960).

Clidinium Bromide CAS Registry Number: 3485-62-9 克利溴铵

CAS Name: 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide
Additional Names: 3-hydroxy-1-methylquinuclidinium bromide benzilate; 1-methyl-3-benziloyloxyquinuclidiniu...
Literature References: Anticholinergic. Prepn: Sternbach, US 2648667 (1953 to Hoffmann-La Roche). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 145-161 (1973).

Tropenzile CAS Registry Number: 53834-53-0

CAS Name: (3-endo, 6-exo)-a-Hydroxy-a-phenylbenzeneacetic acid 6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Additional Names: 6-methoxy-1aH,5aH-tropan-3a-ol benzilate; 6-methoxytropine ...
Literature References: Anticholinergic. Prepn: Stoll et al., Helv. Chim. Acta 38, 571 (1955); CH 325296 (1957 to Sandoz).

Valethamate Bromide CAS Registry Number: 90-22-2 戊沙溴铵

CAS Name: N,N-Diethyl-N-methyl-2-[(3-methyl-1-oxo-2-phenylpentyl)oxy]ethanaminium bromide
Additional Names: 3-methyl-2-phenylvaleric acid diethyl(3-hydroxyethyl)methylammonium bromide ester; 2-...
Literature References: Anticholinergic. Prepn: Stühmer, Funke, DE 969245; DE 971136; DE 1112989 (all 1958 to Kali-Chemie); Martin, Habicht, DE 1091124; US 2987517 (1960, 1961 both to Cilag-Chemie).

Nicofetamide CAS Registry Number: 553-06-0 N-(1,2-二苯基乙基)烟酰胺

CAS Name: N-(1,2-Diphenylethyl)-3-pyridinecarboxamide
Additional Names: 1-nicotinylamino-1,2-diphenylethane; N-(1,2-diphenylethyl)nicotinamideTrademarks: Lyspamin (Bracco)
Percent Compositio...
Literature References: Anticholinergic. Prepn: Suter, US 2483250 (1949 to Cilag).