其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Buzepide CAS Registry Number: 3691-21-2 六氢-alpha,alpha-二苯基-1H-氮杂卓-1-丁酰胺

CAS Name: Hexahydro-a,a-diphenyl-1H-azepine-1-butanamide
Additional Names: 2,2-diphenyl-4-hexamethyleneiminobutyramidePercent Composition: C 78.53%, H 8.39%, N 8.33%, O 4.76%
Literature References: Anticholinergic. Prepn: Janssen et al., J. Med. Pharm. Chem. 1, 187 (1959); of methiodide as well as free base: Janssen, de Jongh, US 2881165 (1959 to N.V. Nederlandsche Combinatie Chem. Ind.). Clinical trial in irritable bowel syndrome: J. Ph. Barbier et al., Ann. Gastroenterol. Hepatol. 25, 123 (1989).

Benzetimide CAS Registry Number: 14051-33-3 3-苯基-1'-(苯基甲基)-[3,4'-联哌啶]-2,6-二酮

CAS Name: 3-Phenyl-1'-(phenylmethyl)-[3,4'-bipiperidine]-2,6-dione
Additional Names: 2-(1-benzyl-4-piperidyl)-2-phenylglutarimide; 1-benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)piperidine
Perce...
Literature References: Anticholinergic. Prepn: Janssen, US 3125578 (1964 to Janssen); Hermans et al., J. Med. Chem. 11, 797 (1968). Synthesis of labelled compound: van Wijngaarden, Soudijn, J. Labelled Compd. 1, 207 (1965). Resolution of isomers and pharmacology: van Wijngaarden, Life Sci. 8, 517 (1969); ibid. 9, part 1, 489 (1970); Janssen et al., Arzneim.-Forsch. 21, 1365 (1971). Metabolism: van Wijngaarden, Soudijn, Life Sci. 7, 225 (1968).

Ipratropium Bromide CAS Registry Number: 22254-24-6 异丙托溴铵

CAS Name: (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide
Additional Names: 3a-hydroxy-8-isopropyl-1aH,5aH-tropanium bromide (...
Literature References: Anticholinergic. Prepn: K. Zeile et al., ZA 6707766; eidem, US 3505337 (1968, 1970, both to Boehringer, Ing.); W. Schulz et al., Arzneim.-Forsch. 26, 960 (1976). Chemistry and pharmacokinetics: W. Deckers, Postgrad. Med. J. 51, Suppl. 7, 76 (1975). Pharmacology and toxicology: A. Engelhardt, H. Klupp, ibid. 82. Series of articles on pharmacology, toxicology, pharmacokinetics and clinical studies: Arzneim.-Forsch. 26, 974-985, 989-1020 (1976). Toxicity data: L. Sarafana et al., ibid. 985. Review: R. Bauer et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 489-515. Symposium on pharmacology, toxicology and clinical efficacy: Am. J. Med. 81(5A), 1-102 (1986). Review of clinical toxicology: J. D. Truwit, Crit. Care Clin. 7, 639-657 (1991).

Dipiproverine CAS Registry Number: 117-30-6 双哌维林

CAS Name: a-Phenyl-1-piperidineacetic acid 2-(1-piperidinyl)ethyl ester
Additional Names: piperidinoethyl a-piperidinophenylacetate
Percent Composition: C 72.69%, H 9.15%, N 8.48%, O 9.68%
Literature References: Anticholinergic. Prepn: Klosa, Pharmazie 8, 723 (1953); Wunderlich, ibid. 11, 201 (1956); Najer et al., Bull. Soc. Chim. Fr. 1958, 355. Pharmacology: Vaccari et al., Clin. Ter. 32, 483 (1965).

Dihexyverine CAS Registry Number: 561-77-3 双己维林

CAS Name: [1,1'-Bicyclohexyl]-1-carboxylic acid 2-(1-piperidinyl)ethyl ester
Additional Names: 1-cyclohexylcyclohexanecarboxylic acid b-piperidinoethyl ester; dicyclohexylacetic acid 2-piperidi...
Literature References: Anticholinergic. Prepn: Kopp, Tchoubar, Bull. Soc. Chim. Fr. 1952, 84. Pharmacology: Buchel et al., Arch. Sci. Physiol. 16, 57 (1962); 21, 537 (1967); Guyonneau, Med. Exp. 6, 245 (1962).

Endobenzyline Bromide CAS Registry Number: 52080-56-5

CAS Name: 2-[(Bicyclo[2.2.1]hept-5-en-2-ylhydroxyphenylacetyl)oxy]-N,N,N-trimethylethanaminium bromide
Additional Names: choline bromide a-phenyl-5-norbornene-2-glycolate; N,N-dimethylaminoethy...
Literature References: Anticholinergic. Prepn: Kottler, Ohnacker, US 2884426 (1959 to Thomae).

Tridihexethyl Iodide CAS Registry Number: 125-99-5 曲地碘铵

CAS Name: g-Cyclohexyl-N,N,N-triethyl-g-hydroxybenzenepropanaminium iodide
Additional Names: (3-cyclohexyl-3-hydroxy-3-phenylpropyl)triethylammonium iodide; 3-diethylamino-1-cyclohexyl-1-phenyl...
Literature References: Anticholinergic. Prepn: Lobby, US 2913494 (1959 to Am. Cyanamid).

Timepidium Bromide CAS Registry Number: 35035-05-3 噻哌溴铵

CAS Name: 3-(Di-2-thienylmethylene)-5-methoxy-1,1-dimethylpiperidinium bromideTrademarks: Mepidium (Recordati); Sesden (Tanabe)
Percent Composition: C 50.99%, H 5.54%, Br 19.96%, N 3.50%, O 4.0...
Literature References: Anticholinergic. Prepn: M. Kawazu et al., DE 2128808 corresp to US 3764607 (1971, 1973 both to Tanabe). Pharmacological properties: H. Tamaki et al., Jpn. J. Pharmacol. 22, 685 (1972), C.A. 78, 52812 (1973). Metabolism: J. Sugihara, N. Taga, Radioisotopes 26, 238 (1977). Absorption, distribution, excretion: M. Yoshikawa, Oyo Yakuri 14, 179 (1977), C.A. 88, 163772 (1978). Teratological study: Y. Fujisawa et al., ibid. 7, 1293 (1973), C.A. 81, 99413 (1974). Chronic toxicity study: K. Doi et al., ibid. 13, 851 (1977), C.A. 88, 32014 (1978).

Chlorbenzoxamine CAS Registry Number: 522-18-9 氯苄沙明

CAS Name: 1-[2-[(2-Chlorophenyl)phenylmethoxy]ethyl]-4-[(2-methylphenyl)methyl]piperazine
Additional Names: 1-[2-(o-chloro-a-phenylbenzyloxy)ethyl]-4-o-methylbenzylpiperazine; 1-[2'-(o-chlorobe...
Literature References: Anticholinergic. Prepn: Morren et al., Ind. Chim. Belge 22, 409 (1957); Morren, GB 837986 (1960). Toxicity study: Levis et al., Arch. Int. Pharmacodyn. Ther. 118, 167 (1959).

Diphemanil Methylsulfate CAS Registry Number: 62-97-5 甲硫二苯马尼

CAS Name: 4-(Diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate
Additional Names: p-(a-phenylbenzylidene)-1,1-dimethylpiperidinium methylsulfate; N,N-dimethyl-4-piperidylidene-1,1-diphe...
Literature References: Anticholinergic. Prepn: N. Sperber et al., J. Am. Chem. Soc. 73, 5010 (1951); N. Sperber et al., US 2739968 (1956 to Schering). Pharmacological properties and toxicity data: S. Margolin et al., Proc. Soc. Exp. Biol. Med. 78, 576 (1951). Clinical evaluation in treatment of gustatory sweating: O. Laccourreye et al., Laryngoscope 100, 1651 (1990). Clinical pharmacokinetics: A. M. Vidal et al., Eur. J. Clin. Pharmacol. 42, 689 (1992).