其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tropacine CAS Registry Number: 6878-98-4 二苯托品

CAS Name: a-Phenylbenzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Additional Names: 1aH,5aH-tropan-3a-ol diphenylacetate; diphenylacetic acid 3a-tropanyl ester; 3a-tropan...
Literature References: Anticholinergic. Prepd from tropine and diphenylacetyl chloride: CH 202181 (1939 to Ciba), C.A. 33, 89228 (1939); Friess et al., Toxicol. Appl. Pharmacol. 2, 574 (1960).

Methantheline Bromide CAS Registry Number: 53-46-3 溴甲胺太林

CAS Name: N,N-Diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]ethanaminium bromide
Additional Names: diethyl(2-hydroxyethyl)methylammonium bromide xanthene-9-carboxylate; b-diethylaminoethyl 9...
Literature References: Anticholinergic. Prepn from 9-xanthenecarboxylic acid and 2-diethylaminoethanol: J. W. Cusic, R. A. Robinson, J. Org. Chem. 16, 1921 (1951); eidem, US 2659732 (1952 to Searle). Pharmacology: W. E. Hambourger et al., J. Pharmacol. Exp. Ther. 99, 245 (1950).

Eucatropine CAS Registry Number: 100-91-4 尤卡托品

CAS Name: a-Hydroxybenzeneacetic acid 1,2,2,6-tetramethyl-4-piperidinyl ester
Additional Names: mandelic acid b-1,2,2,6-tetramethyl-4-piperidyl ester; b-4-hydroxy-1,2,2,6-tetramethylpiperidine ...
Literature References: Anticholinergic. Prepn from higher melting form (b-form) of 1,2,2,6-tetramethyl-4-piperidinol and mandelic acid: Harries, Ann. 296, 328 (1897); Kipping, J. Chem. Soc. 123, 3115 (1923). Description: Harries, Ber. 31, 665 (1898).

Pipenzolate Bromide CAS Registry Number: 125-51-9 溴哌喷酯

CAS Name: 1-Ethyl-3-[(hydroxydiphenylacetyl)oxy]-1-methylpiperidinium bromide
Additional Names: 1-ethyl-3-hydroxy-1-methylpiperidinium bromide benzilate; benzilic acid 1-ethyl-3-piperidyl ester...
Literature References: Anticholinergic. Prepn from N-ethyl-3-chloropiperidine and benzilic acid: Biel et al., J. Am. Chem. Soc. 74, 1485 (1952); US 2918406 (1959 to Lakeside).

Procyclidine CAS Registry Number: 77-37-2 环苯咯丙醇

CAS Name: a-Cyclohexyl-a-phenyl-1-pyrrolidinepropanol
Additional Names: 1-cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol; 1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol
Percent Compositio...
Literature References: Anticholinergic. Prepn of free base and hydrochloride: Adamson et al., J. Chem. Soc. 1951, 52; Adamson, US 2891890 (1959 to Burroughs Wellcome). Prepn of methochloride: Bottorff, US 2826590 (1958 to Lilly); Harfenist, Magnien, US 2842555 (1958 to Burroughs Wellcome).

Bevonium Methyl Sulfate CAS Registry Number: 5205-82-3 甲硫贝弗宁

CAS Name: 2-[[(Hydroxydiphenylacetyl)oxy]methyl]-1,1-dimethylpiperidinium methyl sulfate (salt)
Additional Names: 2-(hydroxymethyl)-1,1-dimethylpiperidinium methyl sulfate benzilate; piribenzil...
Literature References: Anticholinergic. Prepn: BE 616951 (1962 to Grünenthal), C.A. 58, 7914d (1963); Beckmann, Arzneim.-Forsch. 16, 910 (1966). Series of publications on pharmacology, toxicology, clinical trials, see ibid. 901-988.

Caramiphen CAS Registry Number: 77-22-5 卡拉美芬

CAS Name: 1-Phenylcyclopentanecarboxylic acid 2-(diethylamino)ethyl ester
Additional Names: diethylaminoethyl 1-phenylcyclopentane-1-carboxylate
Percent Composition: C 74.70%, H 9.40%, N 4.8...
Literature References: Anticholinergic. Prepn: CH 234452; H. Martin, F. Häfliger, US 2404588 (1945, 1946 both to Geigy). Prepn of the ethanedisulfonate: CH 272708 (1951 to Geigy), C.A. 46, 4563i (1952); Chem. Zentralbl. 1952, 1571. Pharmacology and toxicology of the hydrochloride: C. P. Kraatz et al., J. Pharmacol. Exp. Ther. 96, 42 (1949); of the ethanedisulfonate: J. J. Toner, E. Macko, ibid. 106, 246 (1952). GLC determn in blood: P. Levandoski, T. Flanagan, J. Pharm. Sci. 69, 1353 (1980). Mechanism of antitussive action: E. F. Domino et al., J. Pharmacol. Exp. Ther. 233, 249 (1985).

Oxyphenonium Bromide CAS Registry Number: 50-10-2 奥芬溴铵

CAS Name: 2-[(Cyclohexylhydroxyphenylacetyl)oxy]-N,N-diethyl-N-methylethanaminium bromide
Additional Names: diethyl(2-hydroxyethyl)methylammonium a-phenylcyclohexaneglycolate bromide; a-phenylc...
Literature References: Anticholinergic. Prepn: CH 259948 (1949 to Ciba).

Adiphenine CAS Registry Number: 64-95-9 阿的芬宁

CAS Name: a-Phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
Additional Names: 2-diethylaminoethyl diphenylacetate; diphenylacetyldiethylaminoethanol; diphacil; spasmolytin
Percent Compo...
Literature References: Anticholinergic. Prepn: DE 626539 (1936 to Ciba); and pharmacology: T. Wagner-Jauregg et al., Ber. 72, 1551 (1939); R. R. Burtner, J. W. Cusic, J. Am. Chem. Soc. 65, 262 (1943). Crystal and molecular structure: J. J. Guy, T. A. Hamor, J. Chem. Soc. Perkin Trans. 2 1973, 942. Effect on TSH release: D. Jordan et al., Eur. J. Pharmacol. 41, 53 (1977). HPLC determn in tissues: J. Michelot et al., J. Chromatogr. 257, 395 (1983). Pharmacokinetics: idem et al., Xenobiotica 11, 123 (1981).

Fenpiverinium Bromide CAS Registry Number: 125-60-0 苯维溴铵

CAS Name: 1-(4-Amino-4-oxo-3,3-diphenylbutyl)-1-methylpiperidinium bromide
Additional Names: 1-(3-carbamoyl-3,3-diphenylpropyl)-1-methylpiperidinium bromide; a,a-diphenyl-1-piperidinebutyramide...
Literature References: Anticholinergic. Prepn: GB 708859 (1954 to Hoechst); Moffett, Aspergren, J. Am. Chem. Soc. 79, 4451 (1957). Clinical trial in combination with pitofenone and diclofenac: K. B. Golhar, R. L. Gupta, J. Indian Med. Assoc. 97, 398 (1999).