其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

N,N-Dimethylglycine Hydrazide Hydrochloride CAS Registry Number: 539-64-0 2-(二甲氨基)乙酰肼盐酸盐

Additional Names: Girard's reagent D
Percent Composition: C 31.28%, H 7.87%, Cl 23.08%, N 27.36%, O 10.42%
Literature References: Prepd from N,N-dimethylglycine ethyl ester and hydrazine hydrate in abs alc: Viscontini, Meier, Helv. Chim. Acta 33, 1773 (1950).

Toldimfos Sodium CAS Registry Number: 575-75-7 托定磷钠

CAS Name: (4-Dimethylamino-o-tolyl)phosphonous acid sodium salt
Additional Names: sodium (4-dimethylamino-o-tolyl)phosphonate; p-dimethylamino-o-toluenephosphonous acid sodium salt
Trademark...
Literature References: Prepd from N,N-dimethyl-m-toluidine and phosphorus trichloride: Benda, Schmidt, DE 397813 (1924 to Cassella), Frdl. 14, 1409.

N-Hydroxyethylpromethazine Chloride CAS Registry Number: 2090-54-2

CAS Name: N-(2-Hydroxyethyl)-N,N,a-trimethyl-10H-phenothiazine-10-ethanaminium chloride
Additional Names: (2-hydroxyethyl)dimethyl(1-methyl-2-phenothiazin-10-ylethyl)ammonium chloride; N,N-dime...
Literature References: Prepd from N,N-dimethyl-N-[(a-methyl-b-phenothiazin-10-yl)ethyl]amine and glycol chlorohydrin in methyl ethyl ketone: Carlsson, Karlson, GB 881379 (1961 to Aktiebolaget Recip).

n-Butyl Bromide CAS Registry Number: 109-65-9 正溴丁烷

CAS Name: 1-Bromobutane
Percent Composition: C 35.06%, H 6.62%, Br 58.32%
Literature References: Prepd from n-butyl alc and a hydrobromic-sulfuric acid mixture: Kamm, Marvel, Org. Synth. vol. 1, 5 (1921); Skau, McCullough, J. Am. Chem. Soc. 57, 2440 (1935).

Nicametate CAS Registry Number: 3099-52-3 烟胺乙酯

CAS Name: 3-Pyridinecarboxylic acid 2-(diethylamino)ethyl ester
Additional Names: nicotinic acid 2-diethylaminoethyl ester; diethylaminoethyl 3-pyridinecarboxylate; diethylaminoethyl nicotinate...
Literature References: Prepd from nicotinoyl chloride and diethylaminoethanol or from nicotinic acid and diethylaminoethyl chloride: Blicke, Jenner, J. Am. Chem. Soc. 64, 1722 (1942). Clinical trial in vascular pathology: P. Langeron, J. Sci. Med. Lille 90, 179 (1972). Use of the citrate in cardiovascular surgery: C. Stankowiak et al., Lille Med. 18, 1039 (1973).

Celluloid CAS Registry Number: 8050-88-2 硝化纤维塑料碎屑

Trademarks: Pyralin; Zylonite
Literature References: Prepd from nitrocellulose and camphor.

Nalorphine CAS Registry Number: 62-67-9 烯丙吗啡

CAS Name: (5a,6a)-7,8-Didehydro-4,5-epoxy-17-(2-propenyl)morphinan-3,6-diol
Additional Names: N-allylnormorphine; allorphine; antorphine; NANM
Percent Composition: C 73.29%, H 6.80%, N 4.50%...
Literature References: Prepd from normorphine: McCawley et al., J. Am. Chem. Soc. 63, 314 (1941); amended procedure: Hart, McCawley, J. Pharmacol. 82, 339 (1944); Weijlard, Erickson, J. Am. Chem. Soc. 64, 869 (1942); US 2364833 (1944); Weijlard, US 2891954 (1959 to Merck Co.). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: M. U. Zubair et al., Anal. Profiles Drug Subs. 18, 195-219 (1989).

sym-Diphenylpyrophosphorodiamidic Acid CAS Registry Number: 541-04-8

CAS Name: N,N'-Diphenyl-P,P'-diamidodiphosphoric acid
Percent Composition: C 43.91%, H 4.30%, N 8.54%, O 24.37%, P 18.87%
Literature References: Prepd from O-benzylphenylphosphoroamidic acid: Boger, Friedman, J. Am. Chem. Soc. 80, 2583 (1958).

N-Phenylanthranilic Acid CAS Registry Number: 91-40-7 N-苯基邻氨基苯甲酸(钒试剂)

CAS Name: 2-(Phenylamino)benzoic acid
Additional Names: 2-anilinobenzoic acid; diphenylamine-2-carboxylic acid
Percent Composition: C 73.23%, H 5.20%, N 6.57%, O 15.01%
Literature References: Prepd from o-chlorobenzoic acid and aniline: Ullmann, Dieterle, Ann. 365, 322 (1907); Ullmann, Ber. 36, 2382 (1907); from 2-iodobenzoic acid and phenylhydroxylamine: Wieland, Roseeu, Ber. 48, 1120 (1915). Use: Adamovich, Zagorulko, Zavod. Lab. 9, 465 (1940), C.A. 37, 1346 (1943).

Dymanthine CAS Registry Number: 124-28-7 十八烷基二甲基叔胺

CAS Name: N,N-Dimethyl-1-octadecanamine
Additional Names: N,N-dimethyloctadecylamine; dimantine
Percent Composition: C 80.73%, H 14.57%, N 4.71%
Literature References: Prepd from octadecylamine and formaldehyde: Reck et al., J. Org. Chem. 12, 517 (1947).