其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Xylenol Blue CAS Registry Number: 125-31-5 二甲苯酚蓝

CAS Name: 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis[2,5-dimethylphenol] S,S-dioxide
Additional Names: p-xylenolsulfonephthalein; 1,4-dimethyl-5-hydroxybenzenesulfonephthalein; a,4,4'-trihydroxy-2...
Literature References: Prepd from o-sulfobenzoic acid dichloride or o-sulfobenzoic acid anhydride and p-xylenol in the presence of zinc chloride: Cohen, Biochem. J. 16, 31 (1922).

o-Tolunitrile CAS Registry Number: 529-19-1 邻甲基苯腈

CAS Name: 2-Methylbenzonitrile
Additional Names: 2-methylbenzenecarbonitrile; o-cyanotoluene; o-methylbenzonitrile
Percent Composition: C 82.02%, H 6.02%, N 11.96%
Literature References: Prepd from o-toluidine by diazotization in HCl soln and treatment of the diazonium chloride with potassium cuprocyanide: Herb, Ann. 258, 9 (1890); Clarke, Read, Org. Synth. coll. vol. I (2nd ed., 1941) p 514.

o-Aminoazotoluene CAS Registry Number: 97-56-3 邻氨基偶氮甲苯

CAS Name: 2-Methyl-4-[(2-methylphenyl)azo]benzenamine
Additional Names: C.I. Solvent Yellow 3; 4-(o-tolylazo)-o-toluidine; 4'-amino-2,3'-dimethylazobenzene; 5-(o-tolylazo)-2-aminotoluene; tolua...
Literature References: Prepd from o-toluidine, NaNO2, and HCl: Shulman, US 2538431 (1951 to Pfister Chem. Works); Colour Index vol. 4 (3rd ed., 1971) p 4017. Crystal and molecular structure: S. Kurosaki et al., Acta Crystallogr. 32B, 3160 (1976). Carcinogenic activity: Maini, Stich, J. Natl. Cancer Inst. 26, 1413 (1961). See also: H. J. Conn's Biological Stains, R. D. Lillie, Ed. (Williams Wilkins, Baltimore, 9th ed., 1977) p 87.

Triphenyl Phosphate CAS Registry Number: 115-86-6 磷酸三苯酯

Percent Composition: C 66.26%, H 4.63%, O 19.61%, P 9.49%
Literature References: Prepd from P2O5 and phenol: Prahl, US 2805240 (1957); by reaction of triethyl phosphite with chloramine-T: Cadogan, Moulden, J. Chem. Soc. 1961, 3079. Toxicology: Sutton et al., Arch. Environ. Health 1, 33 (1960).

N-(4-Hydroxyphenyl)glycine CAS Registry Number: 122-87-2 N-(4-羟苯基)苷氨酸

Additional Names: p-Hydroxyphenylaminoacetic acid; p-hydroxyanilinoacetic acid; photoglycine
Trademarks: Glycin; Iconyl; Monazol
Percent Composition: C 57.48%, H 5.43%, N 8.38%, O 28.71%
Literature References: Prepd from p-aminophenol and chloracetic acid: Vater, J. Prakt. Chem. 29, 291 (1884); Meldola et al., J. Chem. Soc. 111, 552 (1917); Galatis, Helv. Chim. Acta 4, 576 (1921).

p-Anisoyl Chloride CAS Registry Number: 100-07-2 对甲氧基苯甲酰氯

CAS Name: 4-Methoxybenzoyl chloride
Percent Composition: C 56.33%, H 4.14%, Cl 20.78%, O 18.76%
Literature References: Prepd from p-anisic acid and thionyl chloride: Vanderhaeghe et al., J. Pharm. Pharmacol. 6, 119 (1954).

Lead Tetraacetate CAS Registry Number: 546-67-8 四乙酸铅

Percent Composition: C 21.67%, H 2.73%, O 28.87%, Pb 46.73%
Literature References: Prepd from Pb3O4 and glacial acetic acid preferably in the presence of some acetic anhydride: Dimroth, Schweizer, Ber. 56, 1375 (1923); Bailar, Inorg. Synth. 1, 47 (1939); Baudler in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1963) p 767. Prepn by electrolysis: Fioshin, Gus'kov, Dokl. Akad. Nauk SSSR 112, 303 (1957), C.A. 51, 16146 (1957); Sataev et al., Khim. Prom. (Moscow) 46, 892 (1970), C.A. 74, 49005x (1971). Reviews of prepn and use as oxidizing agent: Criegee "Oxidations with Lead Tetraacetate" in Oxidation in Organic Chemistry, Part A, K. B. Wiberg, Ed. (Academic Press, New York, 1965) pp 277-366; Zyka, Pure Appl. Chem. 13, 569-581 (1966).

Phenesterine CAS Registry Number: 3546-10-9 苯芥胆甾醇

CAS Name: (3b)-Cholest-5-en-3-ol 4-[bis(2-chloroethyl)amino]benzeneacetate
Additional Names: p-[bis(2-chloroethyl)amino]phenylacetic acid cholesterol ester; cholesteryl p-bis(2-chloroethyl)amin...
Literature References: Prepd from p-bis(2-chloroethyl)aminophenylacetic acid chloride and cholesterol: Shkodinskaya et al., Zh. Obshch. Khim. 32, 959 (1962), C.A. 58, 2502h (1963).

Dyclonine CAS Registry Number: 586-60-7 达克罗宁

CAS Name: 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone
Additional Names: 3-piperidino-4'-butoxypropiophenone; b-piperidinoethyl-4-butoxyphenyl ketone; 4-butoxy-b-piperidinopropiophenone; 4-...
Literature References: Prepd from p-butoxyacetophenone by condensation with formaldehyde and piperidine hydrochloride: Pofft, Chem. Tech. (Berlin) 4, 241 (1952), C.A. 47, 10531 (1953).

Butoxycaine CAS Registry Number: 3772-43-8

CAS Name: 4-Butoxybenzoic acid 2-(diethylamino)ethyl ester
Additional Names: 2-diethylaminoethyl p-butoxybenzoate
Percent Composition: C 69.59%, H 9.28%, N 4.77%, O 16.36%
Literature References: Prepd from p-butoxybenzoyl chloride and b-diethylaminoethanol: Christiansen, Harris, US 2412966 (1946 to Squibb). Alternate prepn and activity: Reynaud et al., Chim. Ther. 2, 25 (1967). See also Büchi et al., Arzneim.-Forsch. 18, 610 (1968).