其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Phthalamide CAS Registry Number: 88-96-0 邻苯二甲酰胺

CAS Name: 1,2-Benzenedicarboxamide
Additional Names: phthalic acid diamide
Percent Composition: C 58.53%, H 4.91%, N 17.06%, O 19.49%
Literature References: Prepd from phthalic anhydride and anhydr ammonia in benzene: Dominikiewicz, Arch. Chem. Farm. 3, 141 (1937).

Phthalimide CAS Registry Number: 85-41-6 邻苯二甲酰亚胺

CAS Name: 1H-Isoindole-1,3(2H)-dione
Percent Composition: C 65.31%, H 3.43%, N 9.52%, O 21.75%
Literature References: Prepd from phthalic anhydride and NH4OH or (NH4)2CO3: W. A. Noyes, P. K. Porter, Org. Synth. coll. vol. I, 457 (2nd ed., 1941). Teratogenicity study: K. Fickentscher et al., Pharmazie 31, 172 (1976).

N-Sulfanilyl-3,4-xylamide CAS Registry Number: 120-34-3 磺胺二甲苯

CAS Name: N-[(-4-Aminophenyl)sulfonyl]-3,4-dimethylbenzamide
Additional Names: N1-(3,4-dimethylbenzoyl)sulfanilamideTrademarks: Irgafen
Percent Composition: C 59.19%, H 5.30%, N 9.20%, O 15....
Literature References: Prepd from p-nitrobenzenesulfonamide and 3,4-dimethylbenzoyl chloride; the resulting p-nitro-N-(3,4-dimethylbenzoyl)benzenesulfonamide is reduced with Fe and dil AcOH: Martin et al., US 2383874 (1945).

Butacaine CAS Registry Number: 149-16-6 二丁氨卡因

CAS Name: 3-(Dibutylamino)-1-propanol 4-aminobenzoate
Additional Names: 3-(p-aminobenzoxy)-1-di-n-butylaminopropane; dibutylaminopropyl-p-aminobenzoate; p-aminobenzoyldibutylaminopropanol
Tr...
Literature References: Prepd from p-nitrobenzoyl chloride and g-di-n-butylaminopropanol followed by reduction of the NO2 group to NH2: O. Kamm et al., US 1358751; Adams, Volwiler, US 1676470; A. Weston, US 2437984 (1920, 1928, 1948 all to Abbott); Burnett et al., J. Am. Chem. Soc. 59, 2248 (1937); Kaye, Roberts, ibid. 73, 4762 (1951). Toxicity study: Schmidt et al., Toxicol. Appl. Pharmacol. 1, 454 (1956).

Chloranil CAS Registry Number: 118-75-2 四氯对醌

CAS Name: 2,3,5,6-Tetrachloro-2,5-cyclohexadiene-1,4-dione
Additional Names: 2,3,5,6-tetrachloro-p-benzoquinone; tetrachloroquinone
Trademarks: Spergon; Vulklor
Percent Composition: C 29....
Literature References: Prepd from p-phenylenediamine or phenol by treating with KClO3 and HCl. Because of its great resistance to further oxidation, chloranil is formed as the final product of the chlorate-HCl oxidation of many aromatic compds. For comprehensive list see Huntress, Organic Chlorine Compounds (New York, 1948). Laboratory procedure starting with phenol or p-chlorophenol: Fierz-David, Blangey, Grundlegende Operationen der Farbenchemie (Vienna, 5th ed., 1943) p 140. Use as reagent for pamaquine, q.v., in urine: Schulemann et al., Chem. Zentralbl. 1928, I, 2193. Aqueous decomposition study: D. H. Sarr et al., Environ. Sci. Technol. 29, 2735 (1995). Review: Health and Environmental Effects Profile for Chloranil (EPA PB88-219696, 1986) 59 pp.

Propipocaine CAS Registry Number: 3670-68-6 丙哌卡因

CAS Name: 3-(1-Piperidinyl)-1-(4-propoxyphenyl)-1-propanone
Additional Names: 3-piperidino-4'-propoxypropiophenone; b-piperidinoethyl 4-propoxyphenyl ketone; 4-n-propoxy-b-(1-piperidyl)propioph...
Literature References: Prepd from p-propoxyacetophenone by condensation with formaldehyde and piperidine HCl: Profft, Chem. Tech. (Leipzig) 4, 241 (1952), C.A. 47, 10531 (1953).

Prednisolone 21-Diethylaminoacetate CAS Registry Number: 5626-34-6 泼尼索酯

CAS Name: N,N-Diethylglycine (11b)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl ester
Additional Names: 11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-(N,N-diethylglycine) ester; prednis...
Literature References: Prepd from prednisolone and N,N-diethylaminoacetyl chloride hydrochloride: Pancrazio, Sbarigia, Farmaco Ed. Prat. 16, 190 (1961); from prednisolone and chloroacetyl chloride followed by reaction with diethylamine: GB 862370 (1961 to Pfizer).

Propyl Sulfide CAS Registry Number: 111-47-7 二丙基硫醚

CAS Name: 1,1'-Thiobispropane
Additional Names: dipropyl sulfide
Percent Composition: C 60.95%, H 11.93%, S 27.12%
Literature References: Prepd from propyl bromide and an alcoholic soln of Na2S.

Propylene Dibromide CAS Registry Number: 78-75-1 1,2-二溴丙烷

CAS Name: 1,2-Dibromopropane
Percent Composition: C 17.85%, H 3.00%, Br 79.16%
Literature References: Prepd from propyl bromide and Br in the presence of AlCl3 or AlBr3.

Propylene Dichloride CAS Registry Number: 78-87-5 1,2-二氯丙烷

CAS Name: 1,2-Dichloropropane
Percent Composition: C 31.89%, H 5.35%, Cl 62.75%
Literature References: Prepd from propyl chloride and Sb2Cl5. Toxicity data: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969). Review of toxicology and human exposure: Toxicological Profile for 1,2-Dichloropropane (PB90-182122, 1989) 131 pp.