其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Loflucarban CAS Registry Number: 790-69-2 氯氟卡班

CAS Name: N-(3,5-Dichlorophenyl)-N'-(4-fluorophenyl)thiourea
Additional Names: 3,5-dichloro-4'-fluorothiocarbanilide
Trademarks: Fluonilid (Continental Pharma)
Percent Composition: C 49.5...
Literature References: Prepd from p-fluorophenyl isothiocyanate and 3,5-dichloroaniline or from 3,5-dichlorophenyl isothiocyanate and p-fluoroaniline: BE 613154 (1962 to Madan), C.A. 58, 474f (1963).

Phenylglyceryl Ether CAS Registry Number: 538-43-2 3-苯氧基-1,2-丙二醇

CAS Name: 3-Phenoxy-1,2-propanediol
Trademarks: Antodyne
Percent Composition: C 64.27%, H 7.19%, O 28.54%
Literature References: Prepd from phenol and 3-chloro-1,2-propylene carbonate: Smith, US 2967892 (1961 to Dow). Toxicity study: Hine et al., J. Pharmacol. Exp. Ther. 97, 414 (1949).

Phenyl Acetate CAS Registry Number: 122-79-2 乙酸苯酯

CAS Name: Acetic acid phenyl ester
Additional Names: acetylphenol
Percent Composition: C 70.57%, H 5.92%, O 23.50%
Literature References: Prepd from phenol and acetyl chloride.

p-Benzylphenol CAS Registry Number: 101-53-1 4-苄基苯酚

CAS Name: 4-(Phenylmethyl)phenol
Additional Names: a-phenyl-p-cresol; (4-hydroxydiphenyl)methane
Percent Composition: C 84.75%, H 6.57%, O 8.68%
Literature References: Prepd from phenol and benzyl chloride in the presence of zinc chloride: Ziegenbein et al., Ber. 88, 1906 (1955).

Phenoxyacetic Acid CAS Registry Number: 122-59-8 苯氧乙酸

Additional Names: Phenoxyethanoic acid; O-phenylglycolic acid; phenyl ether glycolic acid
Trademarks: Phenylium
Percent Composition: C 63.15%, H 5.30%, O 31.55%
Literature References: Prepd from phenol and monochloroacetic acid: Giacosa, J. Prakt. Chem. [2] 19, 396 (1879); van Alphen, Rec. Trav. Chim. 46, 148 (1927).

Phenyl Phthalate CAS Registry Number: 84-62-8 邻苯二甲酸二苯酯

CAS Name: 1,2-Benzenedicarboxylic acid diphenyl ester
Additional Names: diphenyl phthalate
Percent Composition: C 75.46%, H 4.43%, O 20.10%
Literature References: Prepd from phenol and phthalic anhydride.

Ahistan CAS Registry Number: 518-61-6 达赛马嗪

CAS Name: 10-(Dimethylamino)acetyl-10H-phenothiazine
Additional Names: 10-(N,N-dimethylglycyl)phenothiazine; dacemazine
Percent Composition: C 67.58%, H 5.67%, N 9.85%, O 5.63%, S 11.28%
Literature References: Prepd from phenothiazine and chloroacetyl chloride, followed by treatment with dimethylamine: Cusic, US 2694705 (1954 to Searle).

Cupferron CAS Registry Number: 135-20-6 N-亚硝基苯胲铵盐

CAS Name: N-Hydroxy-N-nitrosobenzenamine ammonium salt
Additional Names: N-nitrosophenylhydroxylamine ammonium salt
Percent Composition: C 46.45%, H 5.85%, N 27.08%, O 20.62%
Literature References: Prepd from phenylhydroxylamine by treating with NaNO2 at 0° in presence of HCl, filtering, dissolving in ether and treating with NH3, or by treating an ether soln of phenylhydroxylamine with butyl or amyl nitrite and NH3 in the cold: Marvel, Kamm, Org. Synth. 4, 19 (1925).

Triphenylphosphine CAS Registry Number: 603-35-0 三苯基膦

Percent Composition: C 82.43%, H 5.76%, P 11.81%
Literature References: Prepd from phenylmagnesium bromide and phosphorus trichloride: Pfeiffer, Pietsch, Ber. 37, 4621 (1904); Sauvage, Compt. Rend. 139, 675 (1904); Dodonon, Medox, Ber. 61, 910 (1928); Denney et al., J. Am. Chem. Soc. 83, 1729 (1961).

N,N ¢ -Carbonyldiimidazole CAS Registry Number: 530-62-1 N,N'-羰基二咪唑(CDI)

CAS Name: 1,1'-Carbonylbis-1H-imidazole
Percent Composition: C 51.85%, H 3.73%, N 34.55%, O 9.87%
Literature References: Prepd from phosgene and imidazole in dry tetrahydrofuran or dry benzene: Staab, Ann. 609, 75 (1957); Anderson, Paul, J. Am. Chem. Soc. 80, 4423 (1958).