其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

L -Gulonic Acid CAS Registry Number: 526-97-6 L-古洛糖酸

Additional Names: Xylosecarboxylic acid
Percent Composition: C 36.74%, H 6.17%, O 57.09%
Literature References: Prepd from L-xylose and HCN followed by hydrolysis of the nitrile: Fischer, Stahel, Ber. 24, 529 (1891). Prepn from D-glucuronic acid: DE 618907 (1935 to Hoffmann-La Roche); from L-gulonolactone: Ishidate et al., Chem. Pharm. Bull. 13, 173 (1965).

Di-tert-butyl Malonate CAS Registry Number: 541-16-2 丙二酸二叔丁酯

CAS Name: Propanedioic acid bis(1,1-dimethylethyl) ester
Additional Names: malonic acid di-tert-butyl ester
Percent Composition: C 61.09%, H 9.32%, O 29.59%
Literature References: Prepd from malonic acid, liq isobutylene and sulfuric acid: McCloskey et al., Org. Synth. 34, 26 (1954).

Ammonium Mandelate CAS Registry Number: 530-31-4 扁桃酸铵

CAS Name: a-Hydroxybenzeneacetic acid monoammonium salt
Additional Names: mandelic acid ammonium salt
Percent Composition: C 56.79%, H 6.55%, N 8.28%, O 28.37%
Literature References: Prepd from mandelic acid and NH3 or excess of strong NH3-water: Tabern et al., US 2220692 (1941 to Abbott); Baker, US 2209314 (1941 to Squibb).

Diacetonamine CAS Registry Number: 625-04-7 双丙酮胺草酸盐

CAS Name: 4-Amino-4-methyl-2-pentanone
Percent Composition: C 62.57%, H 11.38%, N 12.16%, O 13.89%
Literature References: Prepd from mesityl oxide with aq NH3: Haeseler, J. Am. Chem. Soc. 47, 1195 (1925); Orthner, Ann. 456, 245 (1927); Haeseler, Org. Synth. coll. vol. I (2nd ed., 1941) p 196. From mesityl oxide with liquid ammonia: Smith, Adkins, J. Am. Chem. Soc. 60, 408 (1938).

p-Anisic Acid CAS Registry Number: 100-09-4 对甲氧基苯甲酸

CAS Name: 4-Methoxybenzoic acid
Percent Composition: C 63.15%, H 5.30%, O 31.55%
Literature References: Prepd from methoxybenzene: Gross et al., Ber. 96, 1382 (1963). Manuf by catalytic oxidation of p-methoxytoluene: GB 798619 (1958 to General Electric); Cotterill et al., GB 842998 (1960 to I.C.I.).

Meparfynol CAS Registry Number: 77-75-8 甲戊炔醇

CAS Name: 3-Methyl-1-pentyn-3-ol
Additional Names: ethyl ethynyl methyl carbinol; 2-ethynyl-2-butanol; methylparafynol; methylpentynol
Trademarks: Allotropal (Heyl); Anti-Stress (Sintyal); A...
Literature References: Prepd from methyl ethyl ketone and sodium acetylide in liquid ammonia or by a Grignard reaction: DE 285770 (1913 to Bayer); also DE 289800 and DE 291185 see Frdl. 12, 55, 56, 57; Sung Wouseng, Ann. Chim. [10] 1, 343 (1924); Rupe, Vonaesch, Ann. 442, 80 (1925); Carothers, Coffman, J. Am. Chem. Soc. 54, 4071 (1932); Campbell et al., ibid. 60, 2882 (1938); Campbell, Campbell, Proc. Indiana Acad. Sci. 50, 123-127 (1940), C.A. 35, 5471; Smith, US 2385547 (1945 to Commercial Solvents); A. W. Johnson, The Chemistry of the Acetylenic Compounds vol. I (Edward Arnold Co., London, 1946) p 278; Hurd, McPhee, J. Am. Chem. Soc. 69, 239 (1947); P. Piganiol, Acetylene Homologs and Derivatives (Brooklyn, 1950); Papa et al., Arch. Biochem. Biophys. 33, 482 (1951); Thiele, Martinez, Ciencia (Mexico City) 15, 70 (1955). An optically active form has been described by Hickmann, Kenyon, J. Chem. Soc. 1955, 2051. Toxicity data: Margolin et al., Science 114, 384 (1951).

Diphenylmethane CAS Registry Number: 101-81-5 二苯甲烷

CAS Name: 1,1'-Methylenebis[benzene]
Additional Names: benzylbenzene; ditan
Percent Composition: C 92.81%, H 7.19%
Literature References: Prepd from methylene chloride and benzene with aluminum chloride as catalyst: Friedel, Crafts, Bull. Soc. Chim. [2] 41, 324 (1884); from benzyl chloride and benzene: Hartman, Phillips, Org. Synth. 14, 34 (1934); L. F. Fieser, Experiments in Organic Chemistry (Boston, 3rd ed., 1955) p 157.

Trimetozine CAS Registry Number: 635-41-6 曲美托嗪,三甲氧啉

CAS Name: 4-(3,4,5-Trimethoxybenzoyl)morpholine
Additional Names: N-(3,4,5-trimethoxybenzoyl)tetrahydro-1,4-oxazineTrademarks: Opalène (Thaplix); Trioxazine (Labatec)
Percent Composition: C...
Literature References: Prepd from morpholine and 3,4,5-trimethoxybenzoyl chloride: GB 872350 (1961 to Egyesült Gyogyszer és Tápszergyár); Pettit et al., J. Med. Pharm. Chem. 5, 800 (1962).

Benzathine CAS Registry Number: 140-28-3 N,N-二苄基乙二胺

CAS Name: N,N'-Bis(phenylmethyl)-1,2-ethanediamine
Additional Names: N,N'-dibenzylethylenediamine; 1,2-bis(benzylamino)ethane; DBED
Percent Composition: C 79.96%, H 8.39%, N 11.66%
Literature References: Prepd from N,N¢-dibenzenesulfonyl-N,N¢-dibenzylethylenediamine by heating with concd HCl in bomb tube at 170-180°: Bleier, Ber. 32, 1829 (1899); from ethylene chloride and benzylamine: Frost et al., J. Am. Chem. Soc. 71, 3842 (1949); by reduction of N,N¢-dibenzylideneethylenediamine: DE 98031 (1898 to Schering); Chem. Zentralbl. 1898, II, 743; Van Alphen, Rec. Trav. Chim. 54, 93 (1935); Lob, ibid. 55, 859 (1936); Szabo et al., Antibiot. Chemother. 1, 499 (1951); Rebenstorf, US 2773098 (1956 to Upjohn).

Benzothiazole CAS Registry Number: 95-16-9 苯并噻唑

Percent Composition: C 62.19%, H 3.73%, N 10.36%, S 23.72%
Literature References: Prepd from N,N-dimethylaniline and sulfur: Knowles, Watt, J. Org. Chem. 7, 56 (1942). Chemistry of benzothiazoles, their use as carbonyl equivalents and in carbon-carbon bond formation: E. J. Corey, D. L. Boger, Tetrahedron Lett. 1978, 5, 9, 13. Toxicity study: E. F. Domino et al., J. Pharmacol. Exp. Ther. 105, 486 (1952).