其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Euprocin CAS Registry Number: 1301-42-4 尤普罗辛

CAS Name: (8a,9R)-10,11-Dihydro-6'-(3-methylbutoxy)cinchonan-9-ol
Additional Names: hydrocupreine isopentyl ether; isoamylhydrocupreine; isopentylhydrocupreine; eucupine
Trademarks: Eucupin ...
Literature References: Prepd from hydrocupreine and p-toluenesulfonic acid isopentyl ester: Slotta, Behnisch, Ber. 66, 360 (1933).

Monobenzone CAS Registry Number: 103-16-2 莫诺苯宗

CAS Name: 4-(Phenylmethoxy)phenol
Additional Names: p-(benzyloxy)phenol; hydroquinone monobenzyl ether; hydroquinone benzyl ether; p-hydroxyphenyl benzyl ether; benzyl hydroquinone; monobenzyl ...
Literature References: Prepd from hydroquinone and benzyl bromide in alcoholic KOH: Schiff, Pellizzari, Ann. 221, 370 (1883). Clinical evaluation: S. W. Becker, Jr., M. C. Spencer, J. Am. Med. Assoc. 180, 279 (1962). Toxicity study: A. Takahashi, E. A. Inglis, Int. J. Polymer Sci. Technol. 3, 93 (1976).

Oxyphenisatin Acetate CAS Registry Number: 115-33-3 双醋酚丁

CAS Name: 3,3-Bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one
Additional Names: 3,3-bis(p-acetoxyphenyl)oxindole; acetphenolisatin; endophenolphthalein; diacetyldiphenolisatin; diacetyldihy...
Literature References: Prepd from isatin by treatment with phenol followed by acetylation in the presence of H2SO4 at temps below 100°: Baeyer, Lazarus, Ber. 18, 2641 (1885); Hoffmann-La Roche, CH 100806; DE 406210 (1923); US 1624675 (1927); DE 482435 (1929); Mizuno, Turuga, JP 129200 (1939).

Isoamyl Bromide CAS Registry Number: 107-82-4 溴代异戊烷

CAS Name: 1-Bromo-3-methylbutane
Percent Composition: C 39.76%, H 7.34%, Br 52.90%
Literature References: Prepd from isoamyl alcohol, bromine and phosphorus or by refluxing isoamyl alcohol with HBr in presence of H2SO4: Kamm, Marvel, Org. Synth. vol. 1, p 4 (1921).

Isobutyl Chlorocarbonate CAS Registry Number: 543-27-1 氯甲酸异丁酯

CAS Name: Carbonochloridic acid 2-methylpropyl ester
Additional Names: isobutyl chloroformate
Percent Composition: C 43.97%, H 6.64%, Cl 25.96%, O 23.43%
Literature References: Prepd from isobutyl alcohol and phosgene.

Isobutyl Carbamate CAS Registry Number: 543-28-2 异丁基氨基甲酸酯

Percent Composition: C 51.26%, H 9.46%, N 11.96%, O 27.31%
Literature References: Prepd from isobutyl chloroformate and NH3 in benzene soln.

Neopentyl Glycol CAS Registry Number: 126-30-7 新戊二醇(NPG)

CAS Name: 2,2-Dimethyl-1,3-propanediol
Additional Names: dimethyltrimethylene glycol
Percent Composition: C 57.66%, H 11.61%, O 30.72%
Literature References: Prepd from isobutyraldehyde.

Isovaleryl Diethylamide CAS Registry Number: 533-32-4 N,N-二乙基异戊酰胺

CAS Name: N,N-Diethyl-3-methylbutyramide
Additional Names: N,N-diethylisovaleramide
Trademarks: Valyl; Xalyl
Percent Composition: C 68.74%, H 12.18%, N 8.91%, O 10.17%
Literature References: Prepd from isovaleric acid and diethylamine: Liebrecht, DE 129967 (1902); Frdl. 6, 1226; from ethyl isovalerate and lithium diethylamide: Hamell, Levine, J. Org. Chem. 15, 162 (1950); by reduction of N,N-diethyl-b-methylcrotonamide with lithium aluminum hydride: Snyder, Putnam, J. Am. Chem. Soc. 76, 1893 (1954).

Isoamyl Cyanide CAS Registry Number: 542-54-1 4-甲基戊腈

CAS Name: 4-Methylpentanenitrile
Additional Names: isocapronitrile
Percent Composition: C 74.17%, H 11.41%, N 14.42%
Literature References: Prepd from KCN and isoamyl chloride in boiling alcohol.

Arginine Glutamate CAS Registry Number: 4320-30-3 L-精氨酸-L-谷氨酸

CAS Name: L-Glutamic acid compd with L-arginine
Trademarks: Modumate (Abbott)
Percent Composition: C 41.12%, H 7.21%, N 21.79%, O 29.87%
Literature References: Prepd from L-arginine and L-glutamic acid: Barker, Chang, US 2851482 (1958 to General Mills). Activity studies: Weisburger et al., Toxicol. Appl. Pharmacol. 14, 163 (1969); Yamamoto, Weisburger, Life Sci. 9(II), 285 (1970). Crystal and molecular structure: T. N. Bhat, M. Vijayan, Acta Crystallogr. B33, 1754 (1977). Reduction of blood ammonia: L. Zieve et al., Metab. Brain Dis. 4, 113 (1989).