其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dehydroergosterol CAS Registry Number: 516-85-8 脱氢麦角甾醇

CAS Name: (3b,22E)-Ergosta-5,7,9(11),22-tetraen-3-ol
Percent Composition: C 85.22%, H 10.73%, O 4.05%
Literature References: Prepd from ergosterol: Windhaus, Linsert, Ann. 465, 148 (1928); Callow, Rosenheim, J. Chem. Soc. 1933, 387. From isopyrocalciferol: Windhaus, Dimroth, Ber. 70, 376 (1937).

Tetrabarbital CAS Registry Number: 76-23-3 替曲比妥

CAS Name: 5-Ethyl-5-(1-ethylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-ethyl-5-(1-ethylbutyl)barbituric acid; 5-ethyl-5-(1-ethylbutyl)malonylureaTrademarks: Butysal; Butysedal<...
Literature References: Prepd from ethyl 2-ethyl-2-(1-ethylbutyl)malonate + urea: Kopp, Tchoubar, Bull. Soc. Chim. Fr. 1951, 30; Tchoubar, FR 1020357 (1953), C.A. 53, 1389a.

Phenetharbital CAS Registry Number: 357-67-5 非沙比妥

CAS Name: 5,5-Diethyl-1-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5,5-diethyl-1-phenylbarbituric acid; 5,5-diethyl-2,4,6-trioxo-1-phenylhexahydropyrimidine; 1-phenyl-5,5-diethyl...
Literature References: Prepd from ethyl diethylmalonate and phenylurea: Fischer, Dilthey, Ann. 335, 334 (1904); Buck, J. Am. Chem. Soc. 58, 1284 (1936).

Trichloroacetonitrile CAS Registry Number: 545-06-2 三氯乙腈

Additional Names: Trichloromethylnitrile
Trademarks: Tritox
Percent Composition: C 16.64%, Cl 73.66%, N 9.70%
Literature References: Prepd from ethyl trichloroacetate and aq ammonia, and physical and thermodynamic properties: Davies, Jenkin, J. Chem. Soc. 1954, 2374; by action of phosphorus pentoxide on trichloroacetamide: Carpenter, J. Org. Chem. 27, 2085 (1962). Manuf by reaction of methylnitrile, HCl and chlorine gas: Käbisch, US 2745868 (1956 to Degussa). Toxicity study: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962).

Diethylsilane CAS Registry Number: 542-91-6 二乙基硅烷

Percent Composition: C 54.46%, H 13.71%, Si 31.84%
Literature References: Prepd from ethylene and silane: Hurd, US 2537763 (1951); Fritz, Z. Naturforsch. 7b, 207 (1952); White, Rochow, J. Am. Chem. Soc. 76, 3897 (1954); Clasen, Angew. Chem. 70, 180 (1958).

Vinyl Chloride CAS Registry Number: 75-01-4 乙烯基氯

CAS Name: Chloroethylene
Percent Composition: C 38.43%, H 4.84%, Cl 56.72%
Literature References: Prepd from ethylene dichloride and alcoholic potassium: Regnault, Ann. 14, 22 (1835); by halogenation of ethylene: Miller, Jenks, US 2896000 (1959 to National Distillers and Chemical Corp.). Review of mfg processes: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 868-873. Acute toxicity study: L. Prodan et al., Ann. N.Y. Acad. Sci. 246, 154 (1975). Series of articles on toxicology and "vinyl chloride disease": ibid. 1-337. Review: in Kirk-Othmer Encyclopedia of Chemical Technology vol. 12 (John Wiley Sons, 3rd ed., 1983) pp 865-885. Review of carcinogenic risk: IARC Monographs 19, 377-437 (1979); of toxicology and human exposure: Toxicological Profile for Vinyl Chloride (PB98-101132, 1997) 277 pp.

Tetraglyme CAS Registry Number: 143-24-8 四乙二醇二甲醚

CAS Name: 2,5,8,11,14-Pentaoxapentadecane
Additional Names: tetraethylene glycol dimethyl ether; dimethoxytetraethylene glycol
Percent Composition: C 54.03%, H 9.98%, O 35.99%
Literature References: Prepd from ethylene glycol methyl ether and 2,2¢-dichlorodiethyl ether: Zellhoefer, US 2111234 (1935); Ind. Eng. Chem. 29, 550 (1937). Purification: Vogel, J. Chem. Soc. 1948, 618. Toxicity study: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 23, 259 (1941).

Triethyl Phosphine CAS Registry Number: 554-70-1 三乙基膦

Percent Composition: C 60.99%, H 12.80%, P 26.21%
Literature References: Prepd from ethyllithium and phosphorus trichloride: Screttas, Isbell, J. Org. Chem. 27, 2573 (1962). Manuf from white phosphorus, ethylene and hydrogen at elevated pressures: Oppegard, US 2687437 (1954 to du Pont).

Oxamide CAS Registry Number: 471-46-5 草酰二胺

CAS Name: Ethanediamide
Additional Names: oxalamide; oxalic acid diamide; ethanedioic acid diamide
Percent Composition: C 27.28%, H 4.58%, N 31.81%, O 36.33%
Literature References: Prepd from formamide by glow-discharge electrolysis: Brown et al., J. Org. Chem. 27, 3698 (1962). Crystal structure: G. De With, S. Harkema, Acta Crystallogr. 33B, 2367 (1977). Metabolized in body to form oxalic acid.

Benzyl Fumarate CAS Registry Number: 538-64-7 富马酸苄酯

CAS Name: (E)-2-Butenedioic acid bis(phenylmethyl) ester
Additional Names: fumaric acid dibenzyl ester; dibenzyl fumarate
Percent Composition: C 72.96%, H 5.44%, O 21.60%
Literature References: Prepd from fumaric acid and benzyl alcohol: Volwiler, Vliet, J. Am. Chem. Soc. 43, 1672 (1921).