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项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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Diazomethane CAS Registry Number: 334-88-3 重氮甲烷

Additional Names: Azimethylene
Percent Composition: C 28.57%, H 4.80%, N 66.64%
Literature References: Prepd from chloroform and hydrazine by reaction with potassium hydroxide: Staudinger, Kupfer, Ber. 45, 501 (1912); McManus et al., J. Org. Chem. 33, 4272 (1968); from KOH and nitrosomethylurea: Dessaux, Durand, Bull. Soc. Chim. Fr. 1963, 41. These methods yield gaseous diazomethane. The following procedures yield ether solns of diazomethane. From N-nitroso-b-methylaminoisobutyl methyl ketone in ether and isopropanol by reaction with sodium isopropoxide or from the same ketone in ether by reaction with sodium cyclohexoxide: Redemann et al., Org. Synth. 25, 28 (1945). By KOH saponification of nitrosomethylurea in ether: Arndt, Org. Synth. coll. vol. II, 165 (1943), or of nitrosomethylurethan in ether: von Pechmann, Ber. 27, 1888 (1894); 28, 855 (1895); Meerwein, Burneleit, Ber. 61, 1845 (1928). In the laboratory diazomethane may be prepd most simply by the action of alkali on the commercially available N-methyl-N-nitroso-N¢-nitroguanidine, cf. McKay, J. Am. Chem. Soc. 70, 1974 (1948); McKay et al., Can. J. Res. 28, 683 (1950); Fieser and Fieser, Organic Chemistry (Reinhold, New York, 3rd ed., 1956) p 176. Alternate intermediate: p-tolylsulfonylmethylnitrosamide ("Diazald" Aldrich Chemical Co.), see De Boer, Backer, Org. Synth. coll. vol. IV, 250 (1963).

Dehydrocholic Acid CAS Registry Number: 81-23-2 去氢胆酸

CAS Name: (5b)-3,7,12-Trioxocholan-24-oic acid
Additional Names: 3,7,12-triketocholanic acid
Trademarks: Acolen; Bilidren; Cholagon; Chologon; Decholin (Miles); Dehychol (Rexall); Deidrocoli...
Literature References: Prepd from cholic acid by oxidation with CrO3 in glacial acetic acid: Hammarsten in Abderhalden's Handbuch der Biol. Arbeitsmethoden, Abt. I, Teil 6, p 238 (1925); by using chlorine instead of CrO3: Hinkley, Singleton, US 2966499 (1960 to Merck Co.).

Chromic Formate CAS Registry Number: 27115-36-2 三甲酸铬

Percent Composition: C 19.26%, H 1.62%, Cr 27.80%, O 51.32%
Literature References: Prepd from Cr(OH)3 and formic acid: Akhmedli, Negretov, J. Gen. Chem. USSR 20, 2045 (1950).

Chromous Formate CAS Registry Number: 4493-37-2 一水甲酸铬(Ⅱ)

Percent Composition: C 16.91%, H 1.42%, Cr 36.61%, O 45.06%
Literature References: Prepd from CrCl2 and Na formate: Lux, Illman, Ber. 91, 2143 (1958); Earnshaw et al., Proc. Chem. Soc. London 1963, 281. Prepn of blue and red anhydrous forms from hydrated formates: Herzog, Kalies, Z. Chem. 5, 273 (1965).

Ammonium Dithiocarbamate CAS Registry Number: 513-74-6 二硫代氨基甲酸铵

CAS Name: Dithiocarbamic acid monoammonium salt
Additional Names: ammonium sulfocarbamate
Percent Composition: C 10.90%, H 5.49%, N 25.42%, S 58.19%
Literature References: Prepd from CS2 and NH3: Mathes, Inorg. Synth. 3, 48 (1950); Redemann et al., Org. Synth. coll. vol. III, 763 (1955); Gatlow, Hahnkamm, Z. Anorg. Allg. Chem. 364, 161 (1969). Crystal structure: Cappuchi et al., Chem. Commun. 1966, 44l.

Cupric Formate CAS Registry Number: 544-19-4 四水甲酸铜

Additional Names: Tubercuprose
Percent Composition: C 15.64%, H 1.31%, Cu 41.38%, O 41.67%
Literature References: Prepd from cupric carbonate and formic acid: Martin, Waterman, J. Chem. Soc. 1959, 1359.

Cupric Oleate CAS Registry Number: 1120-44-1 (Z)-9-十八烯酸铜(II)盐

CAS Name: 9-Octadecenoic acid copper salt
Percent Composition: C 69.02%, H 10.62%, Cu 10.14%, O 10.22%
Literature References: Prepd from CuSO4 and K oleate: Nelson, Pink, J. Chem. Soc. 1954, 4412.

Cyclohexylcarbinol CAS Registry Number: 100-49-2 环己基甲醇

CAS Name: Cyclohexanemethanol
Additional Names: cyclohexanecarbinol; hydroxymethylcyclohexane; hexahydrobenzyl alcohol
Percent Composition: C 73.63%, H 12.36%, O 14.01%
Literature References: Prepd from cyclohexylmagnesium bromide and formaldehyde in ether: Gilman, Catlin, Org. Synth. coll. vol. I (2nd ed., 1941) p 188; Hiers, Adams, J. Am. Chem. Soc. 48, 2385 (1926); Marvel et al., ibid. 50, 2810 (1928). For prepn of cyclohexylmagnesium bromide see Org. Syn., loc. cit.; Gilman, Zoellner, J. Am. Chem. Soc. 53, 1945 (1931).

d-Bornyl a -Bromoisovalerate CAS Registry Number: 52964-40-6

CAS Name: 2-Bromo-3-methylbutanoic acid 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester
Additional Names: 2-bromo-3-methylbutyric acid ester with d-borneol; borneol a-bromoisovalerate; d-bornyl 2-...
Literature References: Prepd from d-borneol and a-bromoisovaleryl chloride or a-bromovaleric acid with mineral acid: Beilstein vol. 6, p 79.

d-Bornyl Isovalerate CAS Registry Number: 53022-14-3 异戊酸龙脑酯

CAS Name: (1R-endo)-3-Methylbutanoic acid 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester
Additional Names: isovaleric acid d-bornyl ester; borneol isovalerate
Trademarks: Bornyval
Percent C...
Literature References: Prepd from d-borneol and isovaleric acid: Siedler, Pharm. Ztg. 48, 772 (1903); Vavon, Peignier, Bull. Soc. Chim. Fr. 39, 924 (1926).