其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bromal Hydrate CAS Registry Number: 507-42-6 2,2,2-三溴乙烷-1,1-二醇

CAS Name: 2,2,2-Tribromo-1,1-ethanediol
Additional Names: tribromoacetaldehyde hydrate
Percent Composition: C 8.04%, H 1.01%, Br 80.24%, O 10.71%
Literature References: Prepd from bromal and water: Löwig, Ann. 3, 288 (1832). Structure: Jain, Soundararajan, Tetrahedron 20, 1589 (1964).

p-Bromoacetophenone CAS Registry Number: 99-90-1 4-溴苯乙酮

CAS Name: 1-(4-Bromophenyl)ethanone
Additional Names: methyl p-bromophenyl ketone
Percent Composition: C 48.27%, H 3.54%, Br 40.14%, O 8.04%
Literature References: Prepd from bromobenzene and acetic anhydride in CS2 in the presence of anhydr AlCl3: Adams, Noller, Org. Synth. 5, 17 (1925).

Isobutylbenzene CAS Registry Number: 538-93-2 异丁基苯

CAS Name: (2-Methylpropyl)benzene
Additional Names: 2-methyl-1-phenylpropane
Percent Composition: C 89.49%, H 10.51%
Literature References: Prepd from bromobenzene, isobutyl iodide, and sodium preferably in the presence of benzene: Wreden, Znatovicz, Ber. 9, 1606 (1876); Schramm, Monatsh. Chem. 9, 616 (1888); by passing vapors of dimethylbenzyl carbinol and hydrogen over activated charcoal: Zelinsky, Gawerdowskaya, Ber. 61, 1052 (1928).

Fluoroform CAS Registry Number: 75-46-7 三氟甲烷

CAS Name: Trifluoromethane
Percent Composition: C 17.16%, H 1.44%, F 81.41%
Literature References: Prepd from CHCl3 and HF: Meslans, Compt. Rend. 110, 717 (1890); Valentiner, US 643835 (1900); Ruff, Ber. 69, 299 (1936); Whallay, J. Soc. Chem. Ind. London 66, 429 (1947); Kwasnik in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1963) pp 204-205. Early industrial prepn: Pearlson in Fluorine Chemistry vol. I, J. H. Simons, Ed. (Academic Press, New York, 1950) p 467.

Chlorhexadol CAS Registry Number: 3563-58-4 氯醛已醇

CAS Name: 2-Methyl-4-(2,2,2-trichloro-1-hydroxyethoxy)-2-pentanol
Additional Names: 2-methyl-2-hydroxy-4-(2,2,2-trichloro-1-hydroxyethoxy)pentane; 2-hydroxy-2-methyl-4-(2,2,2-trichloro-1-hydrox...
Literature References: Prepd from chloral and 2-methyl-2,4-pentanediol: Christensen, US 2931838 (1960 to Danske Medicinal).

Chloral Ammonia CAS Registry Number: 507-47-1 1-氨基-2,2,2-三氯乙醇

CAS Name: 1-Amino-2,2,2-trichloroethanol
Percent Composition: C 14.61%, H 2.45%, Cl 64.69%, N 8.52%, O 9.73%
Literature References: Prepd from chloral and NH3: Schiff, Ber. 10, 165 (1877); Aschan, ibid. 48, 874 (1915). Believed to be a bimolecular compd, Cl3CCH(OH)NHCH(NH2)CCl3.H2O or C4H8Cl6N2O2.

Carbocloral CAS Registry Number: 541-79-7 卡波氯醛

CAS Name: (2,2,2-Trichloro-1-hydroxyethyl)carbamic acid ethyl ester
Additional Names: ethyl (2,2,2-trichloro-1-hydroxyethyl)carbamate; chloral-urethaneTrademarks: Ural; Uraline; Uralium
Perc...
Literature References: Prepd from chloral and urethane in the presence of HCl: Bischoff, Ber. 7, 628 (1874).

Chlorocyanohydrin CAS Registry Number: 513-96-2 3,3,3-三氯乳腈

CAS Name: 3,3,3-Trichloro-2-hydroxypropanenitrile
Additional Names: 3,3,3-trichlorolactonitrile; 3,3,3-trichloro-2-hydroxypropionitrile; chloral hydrocyanide
Percent Composition: C 20.66%, H...
Literature References: Prepd from chloral hydrate and HCN: Chwala, Wassmuth, Monatsh. Chem. 81, 843 (1950).

Cyanoacetic Acid CAS Registry Number: 372-09-8 氰基乙酸

Additional Names: Malonic mononitrile
Percent Composition: C 42.36%, H 3.55%, N 16.47%, O 37.62%
Literature References: Prepd from chloroacetic acid and NaCN: Ruggli, Businger, Helv. Chim. Acta 25, 35 (1942); Lapworth, Baker, Org. Synth. coll. vol. I, 181 (1941); GB 824640 (1959); Eaker, US 2539238 (1951 to Monsanto).

p-Chloroacetophenone CAS Registry Number: 99-91-2 对氯苯乙酮

CAS Name: 1-(4-Chlorophenyl)ethanone
Additional Names: 4'-chloroacetophenone
Percent Composition: C 62.16%, H 4.56%, Cl 22.93%, O 10.35%
Literature References: Prepd from chlorobenzene and acetic anhydride in the presence of AlCl3: Adams, Noller, Org. Synth. coll. vol. I, 109 (1941). Physical properties: eidem, ibid.; Dreisbach, Martin, Ind. Eng. Chem. 41, 2875 (1949).