其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Benzilic Acid CAS Registry Number: 76-93-7 二苯乙醇酸

CAS Name: a-Hydroxy-a-phenylbenzeneacetic acid
Additional Names: diphenylglycolic acid
Percent Composition: C 73.67%, H 5.30%, O 21.03%
Literature References: Prepd from benzil by the action of concd aq or alc KOH: Adams, Marvel, Org. Synth. vol. 1, p 29 (1921); Ballard, Dehn, ibid. coll. vol. I, 82; Kao, Ma, J. Chem. Soc. 1931, 443.

Diphenylketene CAS Registry Number: 525-06-4 二苯乙烯酮

CAS Name: Diphenylethenone
Percent Composition: C 86.57%, H 5.19%, O 8.24%
Literature References: Prepd from benzil monohydrazone: Smith, Hoehn, Org. Synth. coll. vol. III, 356 (1955).

Benzoguanamine CAS Registry Number: 91-76-9 2,4-二氨基-6-苯基-1,3,5-三嗪

CAS Name: 6-Phenyl-1,3,5-triazine-2,4-diamine
Additional Names: 2,4-diamino-6-phenyl-s-triazine; 4,6-diamino-2-phenyl-s-triazine
Percent Composition: C 57.74%, H 4.85%, N 37.41%
Literature References: Prepd from benzonitrile and dicyandiamide in the presence of Na and liquid ammonia: Jones, US 2735850 (1956 to British Oxygen Co.); from benzonitrile and dicyandiamide in the presence of KOH and methyl Cellosolve: Simons, Saxton, Org. Synth. 33, 13 (1953).

Benzamide CAS Registry Number: 55-21-0 苯甲酰胺

Additional Names: Benzoylamide
Percent Composition: C 69.40%, H 5.82%, N 11.56%, O 13.21%
Literature References: Prepd from benzoyl chloride and ammonium carbonate. Lab prepn: Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 119. Alternate procedure using concd ammonia soln: A. I. Vogel, Practical Organic Chemistry (Longmans, London, 3rd ed., 1959) p 797.

Benzoresorcinol CAS Registry Number: 131-56-6 紫外线吸收剂UV-0

CAS Name: (2,4-Dihydroxyphenyl)phenylmethanone
Additional Names: 2,4-dihydroxybenzophenone; 4-benzoylresorcinol; resbenzophenone; benzophenone-1
Trademarks: Uvinul 400 (BASF)
Percent Comp...
Literature References: Prepd from benzoyl chloride and resorcinol: Dobner, Ann. 210, 246 (1881); by Fries rearrangement: Amin, Shah, J. Indian Chem. Soc. 29, 351 (1952).

Benzyl Methyl Ether CAS Registry Number: 538-86-3 苄基甲基醚

CAS Name: (Methoxymethyl)benzene
Additional Names: methyl benzyl ether
Percent Composition: C 78.66%, H 8.25%, O 13.10%
Literature References: Prepd from benzyl chloride, methanol, and NaOH: Olson et al., J. Am. Chem. Soc. 69, 2451 (1947).

Hydroxyphenamate CAS Registry Number: 50-19-1 奥芬氨酯

CAS Name: 2-Phenyl-1,2-butanediol 1-carbamate
Additional Names: carbamic acid b-ethyl-b-hydroxyphenethyl ester; b-ethyl-b-hydroxyphenethyl carbamic acid ester; b-ethyl-b-hydroxyphenethyl carbam...
Literature References: Prepd from b-ethyl-b-hydroxyphenethyl alcohol and ethyl chloroformate followed by reaction with ammonia: Sifferd, Braitberg, US 3066164 (1962 to Armour-Pharm.). Pharmacology and toxicology: Bastian, Clements, Dis. Nerv. Syst. 22, 9 (1961).

Desthiobiotin CAS Registry Number: 533-48-2 D-脱硫生物素

CAS Name: (4R-cis)-5-Methyl-2-oxo-4-imidazolidinehexanoic acid
Additional Names: 5-methyl-2-oxo-4-imidazolidinecaproic acid; e-(4-methyl-5-imidazolidone-2)-caproic acid; 4-methyl-5-(w-carboxyam...
Literature References: Prepd from biotin by hydrogenolysis of the sulfide linkage: du Vigneaud et al., J. Biol. Chem. 146, 475 (1942). Improved prepn procedure: Melville et al., Science 98, 497 (1943). Synthesis: Melville, J. Am. Chem. Soc. 66, 1422 (1944); Wood, du Vigneaud, ibid. 67, 210 (1945); Duschinsky, Dolan, ibid. 2079; Bourquin et al., Helv. Chim. Acta 28, 528 (1954).

Bismuth Subgallate CAS Registry Number: 22650-86-8

CAS Name: Gallic acid bismuth basic salt
Additional Names: bismuth gallate, basic
Trademarks: B.S.G. (Lemmon); Dermatol (Hoechst)
Percent Composition: C 21.33%, H 1.28%, Bi 53.03%, O 24.3...
Literature References: Prepd from bismuth nitrate and gallic acid in an acetic acid medium. The acetic acid may be replaced with a glycol or mannitol: Pfeiffer, Schmitz, Pharmazie 5, 517 (1950).

Bornyl Salicylate CAS Registry Number: 560-88-3

CAS Name: 2-Hydroxybenzoic acid 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester
Additional Names: salicylic acid bornyl ester; borneol salicylate
Trademarks: Salit (Tenneco)
Percent Composit...
Literature References: Prepd from borneol and salicylic acid: Hagers Handb. Pharm. Praxis Band 1, 210 (Berlin, 1930).