其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Diphenic Acid CAS Registry Number: 482-05-3 2,2'-联苯二甲酸

CAS Name: [1,1'-Biphenyl]-2,2'-dicarboxylic acid
Additional Names: o,o'-bibenzoic acid
Percent Composition: C 69.42%, H 4.16%, O 26.42%
Literature References: Prepd from diazotized anthranilic acid by treatment with a cuproammonia-sulfite reducing agent: Vorländer, Meyer, Ann. 320, 122 (1902); Atkinson, Lawler, Org. Synth. coll. vol. I (2nd ed, 1941) p 222. By chromic acid oxidation of phenanthrenequinone: Roberts, Johnson, J. Am. Chem. Soc. 47, 1399 (1925). By heating potassium o-bromobenzoate with copper powder: Hurtley, J. Chem. Soc. 1929, 1870.

Yellow OB CAS Registry Number: 131-79-3 1-(2-甲基苯基)偶氮萘-2-胺

CAS Name: 1-[(2-Methylphenyl)azo]-2-naphthalenamine
Additional Names: C.I. Solvent Yellow 6; 1-o-tolylazo-2-naphthylamine; FD C Yellow no. 4; Ext. D C Yellow no. 10; C.I. 11390
Percent Com...
Literature References: Prepd from diazotized o-toluidine and b-naphthylamine: Krüss, Z. Phys. Chem. 51, 270 (1905); Norman, J. Chem. Soc. 101, 1913 (1912); Fischer, J. Prakt. Chem. 104, 102 (1922); Hodgson, Foster, J. Chem. Soc. 1942, 30. Toxicity studies: Allmark et al., J. Pharm. Pharmacol. 7, 591 (1955); Hansen et al., Toxicol. Appl. Pharmacol. 5, 16 (1963). Formerly used in the U.S. for coloring oleomargarine.

Methyl Thiocyanate CAS Registry Number: 556-64-9 硫氰酸甲酯

Additional Names: Methyl sulfocyanate
Percent Composition: C 32.85%, H 4.14%, N 19.16%, S 43.85%
Literature References: Prepd from dimethyl sulfate and aq barium thiocyanate. Toxicology: W. F. von Oettingen et al., J. Ind. Hyg. Toxicol. 18, 310 (1936). Toxicity data: H. Ohkawa et al., Pestic. Biochem. Physiol. 2, 85 (1972).

N,N-Dimethylformamide CAS Registry Number: 68-12-2 N,N-二甲基甲酰胺

Additional Names: DMF; DMFA
Percent Composition: C 49.30%, H 9.65%, N 19.16%, O 21.89%
Literature References: Prepd from dimethylamine and formic acid: Mitchell, Reid, J. Am. Chem. Soc. 53, 1879 (1931); Brown, J. Appl. Chem. 1, Suppl. Issue no. 2, S159 (1951); Campbell, US 3015674 (1962 to Commercial Solvents); Surman, US 3072725 (1963 to du Pont); from dimethylamine + HCN: Benneville et al., J. Org. Chem. 21, 772 (1956); from HCN + methanol: Fukuoka, Kominami, Chem. Tech. 1972 (Nov.), 640. Toxicity study: W. Bartsch et al., Arzneim.-Forsch. 26, 1581 (1976). Reviews of chemical uses: R. S. Kittila, Dimethylformamide Chemical Uses (du Pont, Wilmington, 1967) 264 pp and Suppl. (1973) 148 pp; J. S. Pizey, Synthetic Reagents Vol. 1 (John Wiley, New York, 1974) pp 4-99; C. L. Eberling in Kirk-Othmer Encyclopedia of Chemical Technology vol. 11 (Wiley-Interscience, New York, 3rd ed., 1980) pp 263-268. Review of carcinogenic risk: IARC Monographs 47, 171-197 (1989).

Tolonium Chloride CAS Registry Number: 92-31-9 甲苯胺蓝O

CAS Name: 3-Amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
Additional Names: 3-amino-7-dimethylamino-2-methylphenazathionium chloride; toluidine blue O; dimethyltoluthionine chlori...
Literature References: Prepd from dimethyl-p-phenylenediamine, sodium thiosulfate, and o-toluidine: Dändliker, Bernthsen, US 416055 (1888 to BASF). Prepn of hemostatic compositions contg tolonium chloride: D. A. Hoff, US 2809913 (1957 to Warren-Teed). Prepn of clear, colorless, stable, isotonic solns of purified leucotoluidine blue O by reducing toluidine blue O with sodium hydrosulfite at pH 2.5-3.5: B. March, E. E. Moore, US 2571593 (1951 to Abbott). Clinical studies in bleeding disorders: J. Allen et al., Surg. Gynecol. Obstet. 89, 692 (1949). Clinical use for parathyroid identification during thyroidectomy: R. M. Yeager, E. T. Krementz, Ann. Surg. 169, 829 (1969). Acute and chronic toxicity study: T. J. Haley, F. Stolarsky, Stanford Med. Bull. 9, 96 (1951). Review of therapeutic and diagnostic use: A. Mashberg, J. Am. Dent. Assoc. 106, 319-323 (1983). See also Colour Index vol. 4 (3rd ed., 1971) p 4471; H. J. Conn's Biological Stains, R. D. Lillie, Ed. (Williams Wilkins, Baltimore, 9th ed., 1977) p 428.

Ferric Sodium Edetate CAS Registry Number: 15708-41-5 乙二胺四乙酸铁钠

CAS Name: (OC-6-21)-[[N,N'-1,2-Ethanediylbis[N-[(carboxy-kO)methyl]glycinato-kN,kO]](4-)]-ferrate(1-) sodium
Additional Names: sodium [(ethylenedinitrilo)tetraacetato]ferrate(1-); (ethylenedini...
Literature References: Prepd from disodium ethylenediaminetetraacetic acid and ferric nitrate: Sawyer, McKinnie, J. Am. Chem. Soc. 82, 4191 (1960).

Timonacic CAS Registry Number: 444-27-9 噻莫西酸

CAS Name: 4-Thiazolidinecarboxylic acid
Additional Names: ATC; norgamen; thioprolineTrademarks: Detoxepa (Wyeth-Ayerst); Hepalidine (3M Pharma); Heparegen (Syntex); Tiazolidin (UCM)
Percent ...
Literature References: Prepd from DL- or L-cysteine and formaldehyde. Prepn of l-form: Ratner, Clarke, J. Am. Chem. Soc. 59, 200 (1937); of dl- and l-forms: Werner et al., Helv. Chim. Acta 30, 432 (1947); FR M3184 (1965 to Sogespar S.A.), C.A. 63, 12980h (1965). Proton magnetic resonance and conformation: Martin, Mathur, J. Am. Chem. Soc. 87, 1065 (1965). Series of articles on pharmacology and toxicology: Gazz. Med. Ital. 131, 251-286 (1972). Toxicity data: Bertrand, Piton, ibid. 265. Induces reverse transformation of tumor cells to normal. Clinical evaluation in cancer: A. Brugarolas, M. Gosalvez, Lancet 1, 68 (1980).

L -Lysine L -Glutamate CAS Registry Number: 5408-52-6 L-赖氨酸-谷氨酸

Additional Names: L-Glutamic acid L-lysine salt
Percent Composition: C 45.04%, H 7.90%, N 14.33%, O 32.73%
Literature References: Prepd from DL-lysine and L-glutamic acid as an intermediate in the resolution of DL-lysine: Emmick, Rogers, US 2556907; US 2657230 (1951, 1953 both to du Pont).

Deanol CAS Registry Number: 108-01-0 2-(二甲基氨基)乙醇

CAS Name: 2-(Dimethylamino)ethanol
Additional Names: b-dimethylaminoethyl alcohol; N,N-dimethyl-2-hydroxyethylamine
Percent Composition: C 53.90%, H 12.44%, N 15.71%, O 17.95%
Literature References: Prepd from equimolar amounts of ethylene oxide and dimethylamine: Knorr, Ber. 37, 3508 (1904); Hanhart, Ingold, J. Chem. Soc. 1927, 1012. Clinical trial in hyperkinetic children: N. Coleman et al., Psychosomatics 17, 68 (1976); in involuntary movement disorders: D. E. Casey, Dis. Nerv. Syst. 38, 7 (1977).

Neoergosterol CAS Registry Number: 516-98-3 (3beta,17beta)-17-[(2R,3E,5R)-5,6-二甲基-3-庚烯-2-基]雌甾-5(10),6,8-三烯-3-醇

CAS Name: (3b,22E)-19-Norergosta-5,7,9,22-tetraen-3-ol
Percent Composition: C 85.20%, H 10.59%, O 4.20%
Literature References: Prepd from ergosterol: Inhoffen, Ann. 497, 130 (1932); Windaus, Deppe, Ber. 70, 76 (1937); Mosettig, Scheer, J. Org. Chem. 17, 764 (1952). Stereochemistry: Steele et al., J. Am. Chem. Soc. 85, 1134 (1963).