其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Glyceryl Iodide CAS Registry Number: 554-10-9 1-碘-2,3-丙二醇

CAS Name: 3-Iodo-1,2-propanediol
Additional Names: g-iodopropyleneglycol; 3-iodo-1,2-dihydroxypropane
Percent Composition: C 17.84%, H 3.49%, I 62.83%, O 15.84%
Literature References: Prepd from 2,3-epoxy-1-propanol: Kratzl et al., Monatsh. Chem. 93, 49 (1962).

Aminopterin CAS Registry Number: 54-62-6 氨基蝶呤

CAS Name: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
Additional Names: 4-aminofolic acid; 4-aminopteroylglutamic acid; 4-amino-PGA
Percent Composition: C 51.82%, ...
Literature References: Prepd from 2,4,5,6-tetraminopyrimidine sulfate, 2,3-dibromopropionaldehyde and p-aminobenzoylglutamic acid: Seeger et al., J. Am. Chem. Soc. 69, 2567 (1947); from 6-(bromomethyl)-2,4-diaminopteridine HBr: Piper, Montgomery, J. Heterocycl. Chem. 11, 279 (1974). Purification: Loo, J. Med. Chem. 8, 139 (1965). Inhibition of dihydrofolate reductase: J. S. Erickson et al., J. Biol. Chem. 247, 5661 (1972). Use as rodenticide: US 2575168 (1951 to Am. Cyanamid).

Thiopropazate CAS Registry Number: 84-06-0 醋酸奋乃静

CAS Name: 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol acetate
Additional Names: 2-chloro-10-[3-[1-(2-acetoxyethyl)-4-piperazinyl]propyl]phenothiazine; 10-[3-[1-(2-acetoxyethyl)...
Literature References: Prepd from 2-chloro-10-(g-chloropropyl)phenothiazine and piperazine in butanone followed by treatment with b-bromoethyl acetate in toluene: Cusic, US 2766235 (1956); Anderson et al., Arzneim.-Forsch. 12, 937 (1962).

Cyclexanone CAS Registry Number: 15301-52-7

CAS Name: 2-(1-Cyclopenten-1-yl)-2-[2-(4-morpholinyl)ethyl]cyclopentanone
Additional Names: 2-(D-1'-cyclopentenyl)-2-(b-tetrahydroparoxazinoethyl)cyclopentanone; 1-(b-N-morpholinoethyl)-1-cyclo...
Literature References: Prepd from 2-cyclopentylidenecyclopentanone and N-(b-chloroethyl)morpholine: Ueberwasser, DE 1059901; GB 878677 (l959, l961 both to Ciba).

Nitrofurazone CAS Registry Number: 59-87-0 呋喃西林

CAS Name: 2-[(5-Nitro-2-furanyl)methylene]hydrazinecarboxamide
Additional Names: 5-nitro-2-furaldehyde semicarbazone
Trademarks: Amifur (Norwich); Furacin (Eaton); Chemofuran; Furesol; Nifuz...
Literature References: Prepd from 2-formyl-5-nitrofuran and semicarbazide hydrochloride: Stillman, Scott, US 2416234 (1947 to Eaton Labs.). Alternate route: Gever, O'Keefe, US 2927110 (1960 to Norwich Pharmacal). LC-MS/MS determn of residues in meat: P. Mottier et al., J. Chromatogr. A 1067, 85 (2005). Toxicity: J. Godwin et al., J. Am. Med. Assoc. 133, 299 (1947). Tumorigenic activity: Morris et al., Cancer Res. 29, 2145 (1969); Ertürk et al., ibid. 30, 1409 (1970).

Tybamate CAS Registry Number: 4268-36-4 泰巴氨酯

CAS Name: Butylcarbamic acid 2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl ester
Additional Names: carbamate of 2-(hydroxymethyl)-2-methylpentyl ester of butylcarbamic acid; N-butyl-2-methyl-2-...
Literature References: Prepd from 2-methyl-2-propyl-3-hydroxypropyl carbamate + butyl isocyanate: Berger, Ludwig, US 2937119 (1960 to Carter Prod.). Comprehensive description: P. Reisberg et al., Anal. Profiles Drug Subs. 4, 494-515 (1975).

Tenonitrozole CAS Registry Number: 3810-35-3 替诺尼唑

CAS Name: N-(5-Nitro-2-thiazolyl)-2-thiophenecarboxamide
Additional Names: 2-(a-thenoylamino)-5-nitrothiazole; thenitrazoleTrademarks: Atrican (Innotech); Moniflagon (Dieetzout)
Percent Comp...
Literature References: Prepd from 2-thenoyl chloride and 2-amino-5-nitrothiazole: FR M715 (1961 to Chantereau), C.A. 59, 7533g (1963).

Karsil CAS Registry Number: 2533-89-3 二氯己酰草胺

CAS Name: N-(3,4-Dichlorophenyl)-2-methylpentanamide
Additional Names: 3',4'-dichloro-2-methylvaleranilide
Trademarks: Niagara 4562
Percent Composition: C 55.40%, H 5.81%, Cl 27.25%, N 5....
Literature References: Prepd from 3,4-dichloroaniline and 2-methylvaleryl chloride: Dorschner et al., GB 869169 (1961 to FMC).

Nitromide CAS Registry Number: 121-81-3 3,5-二硝基苯甲酰胺

CAS Name: 3,5-Dinitrobenzamide
Percent Composition: C 39.82%, H 2.39%, N 19.90%, O 37.89%
Literature References: Prepd from 3,5-dinitrobenzoyl chloride and ammonium acetate: Finan, Fothergill, J. Chem. Soc. 1962, 2824.

Benzpyrinium Bromide CAS Registry Number: 587-46-2 苄吡溴铵

CAS Name: 3-[[(Dimethylamino)carbonyl]oxy]-1-(phenylmethyl)pyridinium bromide
Additional Names: 1-benzyl-3-hydroxypyridinium bromide dimethylcarbamate; 1-benzyl-3-(dimethylcarbamyloxy)pyridiniu...
Literature References: Prepd from 3-hydroxypyridine dimethylcarbamate and benzyl bromide: Wuest, US 2489247 (1949 to Wm. R. Warner).