其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Roxarsone CAS Registry Number: 121-19-7 4-羟基-3-硝基苯胂酸

CAS Name: 4-Hydroxy-3-nitrophenylarsonic acid
Additional Names: 4-hydroxy-3-nitrobenzenearsonic acid; 3-nitro-4-hydroxyphenylarsonic acid; 2-nitro-1-hydroxybenzene-4-arsonic acid; nitrophenolar...
Literature References: Prepd by treating sodium p-hydroxyphenylarsonate with a mixture of nitric and sulfuric acids at 0°: Benda, Bertheim, Ber. 44, 3446 (1911); DE 224953 C.A. 5, 156 (1911). Toxicity study: Kerr et al., Toxicol. Appl. Pharmacol. 5, 507 (1963). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.

Stannic Selenite CAS Registry Number: 7446-25-5

Percent Composition: O 25.76%, Se 42.38%, Sn 31.86%
Literature References: Prepd by treating stannic oxide with selenious acid: Berzelius, cited in Mellor's vol. X, 832 (1930).

Succinanil CAS Registry Number: 83-25-0 N-苯基琥珀酰亚胺

CAS Name: 1-Phenyl-2,5-pyrrolidinedione
Additional Names: N-phenylsuccinimide; N-phenylbutanimide
Percent Composition: C 68.56%, H 5.18%, N 8.00%, O 18.27%
Literature References: Prepd by treating succinanilic acid with acetyl chloride: Ruggli, Ann. 412, 4 (1916); Warren, Briggs, Ber. 64, 29 (1931); L. F. Fieser, Experiments in Organic Chemistry (Boston, 1955) p 106.

Tryptophol CAS Registry Number: 526-55-6 色醇,吲哚-3-乙醇

CAS Name: 3-Indoleethanol
Additional Names: 3-w-hydroxyethylindole; 2-(3-indolyl)ethyl alcohol; 2-indolyl(3)-ethanol; b-indolylethyl alcohol; 3-b-hydroxyethylindole
Percent Composition: C 74...
Literature References: Prepd by treatment of indolemagnesium bromide with ethylene oxide: Oddo, Cambieri, Gazz. Chim. Ital. 60, 19 (1939); Snyder, Pilgrim, J. Am. Chem. Soc. 70, 1962 (1948); by Bouveault-Blanc reduction of 3-indoleacetic ester: Jackson, J. Biol. Chem. 88, 659 (1930); by treatment of indolemagnesium iodide with ethylene chlorohydrin: Majima, Hoshino, Ber. 58, 2042 (1925); from gramine: Snyder, Pilgrim, J. Am. Chem. Soc. 70, 3770 (1948). By lithium aluminum hydride reduction of methyl 3-indoleglycolate: Speeter, Anthony, US 3076814 (1963 to Upjohn).

Chromic Potassium Oxalate CAS Registry Number: 14217-01-7

CAS Name: Tripotassium tris(ethanedioato)chromate(3-)
Additional Names: tripotassium tris(oxalato)chromate(3-); potassium trioxalatochromate(III); potassium chromic oxalate
Percent Compositi...
Literature References: Prepd by treatment of oxalic acid and K2C2O4 with K2Cr2O7: Bailar, Jr., Jones, Inorg. Synth. 1, 37 (1939); Hein, Herzog in Handbook of Preparative Inorganic Chemistry vol. 2, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1965) p 1372.

Methacrylonitrile CAS Registry Number: 126-98-7 甲基丙烯腈

CAS Name: 2-Methyl-2-propenenitrile
Additional Names: isopropenylnitrile; a-methylacrylonitrile; isopropene cyanide
Percent Composition: C 71.61%, H 7.51%, N 20.88%
Literature References: Prepd by vapor-phase catalytic oxidation of methallylamine: Peters et al., Ind. Eng. Chem. 40, 2046 (1948); US 2375016 (1945 to Shell); by the dehydration of methacrylamide: Kung, US 2373190 (1945 to Goodrich); from isopropylene oxide and ammonia: Spillane, Kayser, US 2557703 (1951 to Allied Chem.). Toxicity study: Smyth et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962).

Phosphorus Hemitriselenide CAS Registry Number: 1314-81-4

Percent Composition: P 20.73%, Se 79.27%
Literature References: Prepd by warming a mixture of phosphorus and selenium in the correct proportions: Hahn, J. Prakt. Chem. [1] 93, 430 (1864); Muthmann, Clever, Z. Anorg. Chem. 13, 191 (1897); Meyer, ibid. 30, 258 (1902); 61B, 1807 (1928).

Chloral Betaine CAS Registry Number: 2218-68-0 氯醛甜菜碱

CAS Name: 1-Carboxy-N,N,N-trimethylmethanaminium inner salt compd with 2,2,2-trichloro-1,1-ethanediol (1:1)
Trademarks: Beta-Chlor (Mead Johnson); Somilan (BDH)
Percent Composition: C 29.76%...
Literature References: Prepd by warming betaine hydrate and chloral hydrate: Petrow et al., GB 874246 (1959 to British Drug Houses).

Aceturic Acid CAS Registry Number: 543-24-8 N-乙酰甘氨酸

CAS Name: N-Acetylglycine
Additional Names: acetamidoacetic acid; acetylaminoacetic acid; acetylglycocoll; ethanoylaminoethanoic acid
Percent Composition: C 41.03%, H 6.03%, N 11.96%, O 40.9...
Literature References: Prepd by warming glycine with a slight excess of acetic anhydride in benzene: Radenhausen, J. Prakt. Chem. [2] 52, 437 (1895); by warming glycine in glacial acetic acid with the stoichiometric amount of acetic anhydride: Dakin, J. Biol. Chem. 82, 443 (1929).

Phenylhydroxylamine CAS Registry Number: 100-65-2 N-苯基羟胺

CAS Name: N-Hydroxybenzenamine
Additional Names: b-phenylhydroxylamine; N-phenylhydroxylamine
Percent Composition: C 66.04%, H 6.47%, N 12.83%, O 14.66%
Literature References: Prepd by zinc reduction of nitrobenzene in ammonium chloride soln: Kamm, Org. Synth. 4, 57 (1925).