其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bromcresol Purple CAS Registry Number: 115-40-2 溴甲酚紫

CAS Name: 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis[2-bromo-6-methylphenol] S,S-dioxide
Additional Names: a-(5-bromo-4-hydroxy-m-tolyl)-a-(3-bromo-5-methyl-4-oxo-2,5-cyclohexadien-1-ylidene)-o-to...
Literature References: Prepd by treating o-cresol red with bromine in glacial acetic acid: See refs under Bromcresol Green.

p-Fluorobenzoic Acid CAS Registry Number: 456-22-4 对氟苯甲酸

Percent Composition: C 60.01%, H 3.60%, F 13.56%, O 22.84%
Literature References: Prepd by treating p-carbethoxybenzenediazonium chloride with fluoboric acid, followed by thermal decompn of the resulting p-carbethoxybenzenediazonium fluoborate and by hydrolysis of the ensuing ethyl ester of p-fluorobenzoic acid: Schiemann, Winkelmüller, Org. Synth. 13, 52 (1933).

Quintozene CAS Registry Number: 82-68-8 五氯硝基苯

CAS Name: Pentachloronitrobenzene
Additional Names: PCNB; terrachlor; PKhNB
Trademarks: Botrilex (Bayer); Brassicol (Hoechst); Folosan (Uniroyal); Pentagen (Mitsui Toatsu); Terraclor (Uniroy...
Literature References: Prepd by treating pentachlorobenzene with fuming nitric acid: Jungfleisch, Ann. Chim. [4] 15, 286 (1868); A. Roedig, K. Kiepert, Ann. 593, 71 (1955). Persistence of residues in foods: P. B. Baker, B. Flaherty, Analyst 97, 378 (1972); A. R. P. Paxton, D. Purser, Pestic. Sci. 13, 401 (1982); in soil: J. Beck, K. E. Hansen, ibid. 5, 41 (1974). Metabolism by sheep and goats: P. W. Aschbacher, V. J. Feil, J. Agric. Food Chem. 31, 1150 (1983). Toxicity data: J. K. Finnegan et al., Arch. Int. Pharmacodyn. Ther. 114, 38 (1958). Review: WHO Environmental Health Criteria 41, 1-38 (1984). Comparative review of the effects on soil organisms: E. R. Ingham, Crop Prot. 4, 3-32 (1985).

p-Fluorophenylacetic Acid CAS Registry Number: 405-50-5 对氟苯乙酸

CAS Name: 4-Fluorobenzeneacetic acid
Percent Composition: C 62.34%, H 4.58%, F 12.33%, O 20.76%
Literature References: Prepd by treating p-fluorobenzyl cyanide with sulfuric acid: Olah et al., J. Org. Chem. 22, 879 (1957).

N,N,N ¢ ,N ¢ -Tetraethylphthalamide CAS Registry Number: 83-81-8 邻苯二甲酸二(二乙基酰胺)

CAS Name: N,N,N',N'-Tetraethyl-1,2-benzenedicarboxamide
Additional Names: orthophthalic acid didiethylamide; o-phthalic acid bis[diethylamide]; tetraethylbis(phthalamide)
Trademarks: Analeti...
Literature References: Prepd by treating phthalyl chloride with diethylamine: FR 785428; GB 443396; US 2057145 (1936 to Chem. Fabrik Grünau); by heating sodium phthalate with diethylamine phosphate: FR 866229 (1941 to Corbière).

Starch, Soluble CAS Registry Number: 9005-84-9 可溶性淀粉

Additional Names: Amylodextrin; amylogen
Literature References: Prepd by treating potato or corn starch with dilute hydrochloric acid.

Thiazinamium Methylsulfate CAS Registry Number: 58-34-4 甲硫噻丙铵

CAS Name: N,N,N,a-Tetramethyl-10H-phenothiazine-10-ethanaminium methyl sulfate
Additional Names: trimethyl(1-methyl-2-phenothiazin-10-ylethyl)ammonium methyl sulfate; trimethyl[1-methyl-2-(10-p...
Literature References: Prepd by treating promethazine with dimethyl sulfate: GB 641452 (1950 to Rhône-Poulenc). Crystal structure: P. Marsau, Y. Cam, Acta Crystallogr. B29, 980 (1973). Determn in body fluids: J. H. G. Jonkman et al., J. Pharm. Pharmacol. 27, 849 (1975). Bioavailability: idem et al., Clin. Pharmacol. Ther. 21, 457 (1977). Pharmacokinetics: idem et al., Arzneim.-Forsch. 23, 223 (1983); idem et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 21, 454 (1983).

Pyrocatechol CAS Registry Number: 120-80-9 邻苯二酚

CAS Name: 1,2-Benzenediol
Additional Names: pyrocatechin; catechol; 1,2-dihydroxybenzene
Percent Composition: C 65.45%, H 5.49%, O 29.06%
Literature References: Prepd by treating salicylaldehyde with hydrogen peroxide, or from its monomethyl ether (guaiacol) by treatment with hydrobromic acid: Dakin, Org. Synth. coll. vol. I, 149 (2nd ed., 1941). Toxicity data: A. J. Lehman et al., Adv. Food Res. 3, 197 (1951). Carcinogenicity study: M. Hirose et al., Carcinogenesis 14, 525 (1993). Review: J. Varagnat, "Hydroquinone, Resorcinol, and Catechol", in Kirk-Othmer Encyclopedia of Chemical Technology vol. 13 (Wiley-Interscience, New York, 3rd ed., 1981) pp 39-69.

Salicylsulfuric Acid CAS Registry Number: 89-45-2 2-(磺酰基氧基)苯甲酸

CAS Name: 2-(Sulfooxy)benzoic acid
Additional Names: salicylic acid, acid sulfate; salicylic acid sulfuric acid ester
Percent Composition: C 38.53%, H 2.77%, O 44.00%, S 14.70%
Literature References: Prepd by treating salicylic acid with chlorosulfonic acid in pyridine: Loeper et al., C.R. Seances Soc. Biol. Ses Fil. 135, 917 (1941); Chim. Ind. (Paris) 49, 99 (1943).

Acetylsalicylsalicylic Acid CAS Registry Number: 530-75-6 乙酰水杨酰水杨酸

CAS Name: 2-(Acetyloxy)benzoic acid 2-carboxyphenyl ester
Additional Names: 2-hydroxybenzoic acid acetate 2-carboxyphenyl ester; salicylacetylsalicylic acid
Trademarks: Diplosal Acetate
P...
Literature References: Prepd by treating salicylsalicylic acid q.v., with acetic anhydride or by fractionating an acetylsalicylic acid melt: DE 236196 (1908 to Boehringer).