其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Novoldiamine CAS Registry Number: 140-80-7 2-氨基-5-二乙氨基戊烷

CAS Name: N1,N1-Diethyl-1,4-pentanediamine
Additional Names: 1-diethylamino-4-aminopentane; 4-amino-1-diethylaminopentane; 2-amino-5-diethylaminopentane; d-diethylamino-a-methylbutylamine; d-di...
Literature References: Prepd commercially from 2-diethylaminoethanol and ethyl acetoacetate. 2-Chlorotriethylamine (formed by the action of thionyl chloride on the alcohol) is condensed with the sodium derivative of ethyl acetoacetate to yield an intermediate ester, which is hydrolyzed and decarboxylated to novol ketone (5-diethylamino-2-pentanone). This is hydrogenated in the presence of ammonia to yield novoldiamine. Several other prepns, i.e., from 1,4-pentanediol and diethylamine: Kyrides, US 2365825 (1944 to Monsanto). Purification procedure: Jones, US 2400934 (1946 to Lilly).

Oxymetazoline CAS Registry Number: 1491-59-4 羟甲唑啉

CAS Name: 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
Additional Names: 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol; 2-(4-tert-butyl-2,6-di...
Literature References: Prepd from (4-tert-butyl-2,6-dimethyl-3-hydroxyphenyl)acetonitrile and ethylenediamine: Fruhstorfer, Mueller-Calgan, DE 1117588 (1961 to E. Merck), C.A. 57, 4674a (1962). Toxicity data: Hotovy et al., Arzneim.-Forsch. 11, 1016 (1961).

Benzpiperylon CAS Registry Number: 53-89-4 苄哌立隆

CAS Name: 1,2-Dihydro-2-(1-methyl-4-piperidinyl)-5-phenyl-4-(phenylmethyl)-3H-pyrazol-3-one
Additional Names: 4-benzyl-1-(1-methyl-4-piperidyl)-3-phenyl-3-pyrazolin-5-one; 1-(N-methyl-4-piperid...
Literature References: Prepd from (N-methylpiperidyl)hydrazine and ethyl 2-benzyl-3-oxo-3-phenylpropionate: A. Ebnöther et al., Helv. Chim. Acta 42, 1201 (1959); E. Jucker et al., CH 346885, CH 346886 (1960 both to Sandoz), C.A. 58, 5696a,b (1963). See also: eidem, US 2903460 (1959 to Sandoz). Pharmacological properties, toxicity: A. Cerletti et al., Boll. Chim. Farm. 102, 602 (1963).

Acetophenazine CAS Registry Number: 2751-68-0 乙酰奋乃静

CAS Name: 1-[10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]ethanone
Additional Names: 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazin-2-yl methyl ketone; 2-a...
Literature References: Prepd from 1-(2-hydroxyethyl)piperazine and 10-(3-chloropropyl)-2-acetylphenothiazine: Sherlock, Sperber, US 2985654 (1961 to Schering). Toxicity study: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972).

Trimethidinium Methosulfate CAS Registry Number: 14149-43-0

CAS Name: 1,3,8,8-Tetramethyl-3-[3-(trimethylammonio)propyl]-3-azoniabicyclo[3.2.1]octane bis(methyl sulfate)
Additional Names: 3-[3-(dimethylamino)propyl]-1,3,8,8-tetramethyl-3-azoniabicyclo[3...
Literature References: Prepd from 1-(3-dimethylaminopropyl)-3,4,4-trimethyl-3,5-ethylenepiperidine and methyl sulfate: Schmidt, DE 1086703 (1960 to Thomae), C.A. 55, 27379i (1961). Ganglion blocking agent.

Cyclopropyl Methyl Ether CAS Registry Number: 540-47-6 环丙基甲基醚

CAS Name: Methoxycyclopropane
Additional Names: cyprome ether
Percent Composition: C 66.62%, H 11.18%, O 22.19%
Literature References: Prepd from 1,3-dibromo-2-methoxypropane by reduction with Zn: Olson et al., J. Am. Chem. Soc. 69, 2454 (1947); see also Krantz, Jr. et al., J. Pharmacol. 69, 207 (1940); Krantz, Jr., Drake, US 2330979 (1944); Haller, US 2424029 (1947).

Galactoflavin CAS Registry Number: 5735-19-3

CAS Name: 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-galactitol
Additional Names: 7,8-dimethyl-10-(D-galacto-2,3,4,5,6-pentahydroxyhexyl)benzo[g]pteridine-2,4(3H...
Literature References: Prepd from 1-deoxy-1-(3,4-dimethyl-6-phenylazo)anilino-D-galactitol and barbituric acid: Berezovskii, Eremenko, Zh. Obshch. Khim. 32, 4056 (1962), C.A. 59, 736b (1963). Structure: Emerson et al., J. Biol. Chem. 160, 165 (1945). Pharmacology: Lane, Brindley, Proc. Soc. Exp. Biol. Med. 116, 57 (1964). Produces congenital malformations in animals: Nelson et al., J. Nutr. 58, 125 (1956); Miller et al., J. Biol. Chem. 237, 968 (1962); Mackler, Pediatrics 43, 915 (1969).

Amyl Chloride CAS Registry Number: 543-59-9 氯代正戊烷

CAS Name: 1-Chloropentane
Additional Names: n-amyl chloride; n-butylcarbonyl chloride
Percent Composition: C 56.34%, H 10.40%, Cl 33.26%
Literature References: Prepd from 1-pentanol and concd HCl in sealed tube at 120°: Conant, Kirner, J. Am. Chem. Soc. 46, 245 (1924); with HCl and zinc chloride: Clark, Streight, Trans. R. Soc. Can. Sect. 3 23, III 77 (1929); Vogel, J. Chem. Soc. 1943, 638, 640; for prepn without admixed 2- and 3-chloropentanes see Whitmore's procedure from 1-pentanol with SOCl2 and pyridine: Whitmore et al., J. Am. Chem. Soc. 60, 2540 (1938); Mixer, Young, ibid. 78, 3382 (1956).

Trichlorourethan CAS Registry Number: 107-69-7 2,2,2-三氯乙基氨基甲酸酯

CAS Name: 2,2,2-Trichloroethanol carbamate
Additional Names: trichloroethyl urethan; 2,2,2-trichloroethyl carbamate; carbamic acid trichloroethyl ester
Percent Composition: C 18.72%, H 2.10%...
Literature References: Prepd from 2,2,2-trichloroethyl alcohol and carbamoyl chloride in ether: Willstätter, Duisberg, Ber. 56, 2283 (1923).

Bisoxatin Acetate CAS Registry Number: 14008-48-1 (3-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-2,2-二基)双(4,1-亚苯基)二乙酸酯

CAS Name: 2,2-Bis[4-(acetyloxy)phenyl]-2H-1,4-benzoxazin-3(4H)-one
Additional Names: 2,2-bis(4-acetoxyphenyl)-3-oxo-2,3-dihydrobenz-1,4-oxazineTrademarks: Laxonalin; Maratan (Ravizza); Talsis (...
Literature References: Prepd from 2,2-dichloro-3-oxo-2,3-dihydrobenz-1,4-oxazine and phenylacetate or by acetylation of the diphenol: Seeger, US 3006917 (1961 to Thomae). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).